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    An International, Cross-Sectional Survey of Pediatrics Researchers and Clinicians: Perceptions of Complementary, Alternative, and Integrative Medicine

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    Complementary, alternative, and integrative medicine (CAIM) encompass a broad array of non-conventional health practices and products used alongside or instead of Western medicine. Ranging from acupuncture to yoga, these therapies have gained popularity due to their holistic approach, patient-centered care, and desire to avoid conventional treatment side effects. In the pediatric realm, CAIM is particularly prevalent, with over 10% of pediatric patients utilizing these methods. This percentage rises substantially among children with chronic illnesses, reaching more than 50%. CAIM adoption spans various conditions, such as cancer (6%-91%), autism spectrum disorder (28%-95%), and gastrointestinal issues. Pediatricians' attitudes toward CAIM are diverse, ranging from openness to incorporation in treatment plans to a lack of knowledge and evidence-based concerns. Such divided opinions impede efforts to integrate CAIM effectively and hinder research progress. To comprehend these perspectives comprehensively, a large-scale international survey is proposed. This survey will encompass both pediatric researchers and clinicians, gathering data across diverse healthcare settings and global regions. By assessing attitudes, barriers, and preferences regarding CAIM, the study aims to illuminate hindrances to evidence-based integration and identify educational needs. With CAIM's growing popularity and its intricate reception within the pediatric medical community, the survey outcomes will hold significance in bridging the gap between conventional and unconventional practices. The results will provide important insights on how clinicians and researchers, including both those familiar or largely unfamiliar with CAIM, interact with these practices and products. Additionally, the study will inform which educational initiatives might be most appealing and relevant to this group

    Syekh Yusuf, Mengenang Perjuangan dan Kejuangan Dengan Spirit Keagamaan

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    Syekh Yusuf menjadi lambang perjuangan lintas benua. Dimana setiap tanah yang dipijak, menjadi tempat perjuangan. Mulai dari Banten, Srilanka, sampai ke Afrika Selatan. Perjuangannya, dalam rangka pembebasan manusia dari perbudakan dimana saat itu era penjajahan. Begitu pula dengan semangat belajar yang menjadi bagian dari perjalanannya

    Human Security Index in Indonesia: Learning from Japan Human Security Index

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    The United Nations declares “leaving no one behind” to be a principle of the Sustainable Development Goals (SDGs), but there is a growing recognition that it is inadequate to merely try to meet each target of the SDGs in order to accomplish this

    Differences in Vaccine and SARS-CoV-2 Replication Derived mRNA: Implications for Cell Biology and Future Disease

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    Codon optimization describes the process used to increase protein production by use of alternative but synonymous codon changes. In SARS-CoV-2 mRNA vaccines codon optimizations can result in differential secondary conformations that inevitably affect a protein’s function with significant consequences to the cell. Importantly, when codon optimization increases the GC content of synthetic mRNAs, there can be an inevitable enrichment of G-quartets which potentially form G-quadruplex structures. The emerging G-quadruplexes are favorable binding sites of RNA binding proteins like helicases that inevitably affect epigenetic reprogramming of the cell by altering transcription, translation and replication. In this study, we performed a RNAfold analysis to investigate alterations in secondary structures of mRNAs in SARS-CoV-2 vaccines due to codon optimization. We show a significant increase in the GC content of mRNAs in vaccines as compared to native SARS-CoV-2 RNA sequences encoding the spike protein. As the GC enrichment leads to more G-quadruplex structure formations, these may contribute to potential pathological processes initiated by SARS-CoV-2 molecular vaccination

    Study Summary

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    Question-Asking

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    w/ Karen Huang, Alison Wood Brooks, Julia Minson & Francesca Gin

    Evaluation of The New Student Candidates admission Information System Using ISO/IEC 25010 Model

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    During the COVID-19 pandemic, it is very important to pay attention to the evaluation of the quality of higher education information systems because most of internet users were only accessed from home. So it is necessary to evaluate to produce a quality system. This study aimed to evaluate the information system for the candidate of new student admissions at the Muhammadiyah University of Education Sorong. This evaluation was conducted to find out that SIPMB Unimuda Sorong was designed according to the wishes, and how high the level of user satisfaction was. This study used five characteristics that exist in ISO/IE 25010. The results showed that the usability characteristic test obtained a percentage value of 77% in the Very Eligible category. Meanwhile, in testing the functional suitability characteristics, it obtained a score percentage of 98% in the Very Good category. In testing the performance efficiency characteristics, it has met the standard because the average time used is 3.1 seconds for page load, page size is 866 kb, page speed is in Grade C (72%), and Yslow is in grade A (93%) so that we get very good category. The maintainability characteristic test is carried out by taking into account the three test criteria. The test results showed that the system has met the three categories they were instrumentation, consistency, and simplicity, so that SIPMB has met the maintainability test. And testing the reliability characteristics obtained a percentage value of 100%, this shows that SIPMB has met the Telcordia standard. Based on the results of testing and analysis, it can be said that SIPM UNIMUDA Sorong has product quality in accordance with ISO/IEC 25010 Software Product Quality standards

    Genetically regulated gene expression underlies the regional individuality of human brain organization and disease

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    An understanding of human brain individuality requires the integration of data on brain organization across individuals, molecular and systems scales, as well as healthy and clinical states. Here, we help advance this understanding by leveraging methods from computational genomics to integrate large-scale genomic, transcriptomic, neuroimaging, and electronic-health- record datasets. We first estimated genetically regulated gene expression (gr-expression) of 18,647 genes, across 10 cortical and subcortical regions of 45,549 people from the UK Biobank. We showed that gr-expression patterns reflect known ancestry relationships, regional identities, and inter-regional correlation structure of directly assayed gene expression. We built on these results to discover 1,045 associations between individual variation in gr-expression and regional gray matter volumes. Many of these associations recapitulated previous results from genome- wide association studies (GWAS); however, hundreds of novel associations between genes and regional volumes were not present in GWAS of the same cohort. The significance of individual associations strongly correlated with the brain-relatedness of biological annotations in the NHGRI-EBI Catalog. We next integrated these results with genetic data and electronic health records from the Vanderbilt Biobank and found genes whose gr-expression was associated with regional volumes and with brain disorders. Finally, we identified polygenic associations of gr-expression with structural and functional MRI phenotypes in the Human Connectome Project, a small neuroimaging-genomic dataset with high-quality functional imaging data. Collectively, our results describe a powerful new approach to linking individual variation in gene expression with brain organization and disease

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