A study on the role of high school students in area management on remote islands targeting high schools with study abroad system on remote islands

Many schools on remote islands are closed due to the declining birthrate and aging population. However, the continuation of the school is necessary for regional revitalization. Therefore, a remote island study abroad system was established. Since Nagasaki Prefecture is an advanced region in the remote island study abroad system for high school students, the value of high school students in remote island areas was examined for high schools in Nagasaki Prefecture. As a result, it was found that high school students can contribute to the local community by providing opportunities to think about local issues in club activities and classes. On the other hand, in order to promote study abroad on remote islands, it was found that high school values and mental support for international students are also necessary

Living under ecosystem degradation: Evidence from the mangrove–fishery linkage in Indonesia

This study examines the impacts of ecosystem degradation on social welfare, focusing on the mangrove–fishery linkage in Indonesia. Using nationally representative household data combined with satellite information on spatiotemporal mangrove loss, the study finds that fishery households experienced a decline in annual income ranging from 5.3% to 9.8% in response to a 1% increase in mangrove loss in the region. Under the income shock, fishery households increased their labor input and decreased their non-food consumption; however, they continued being part of the fishery industry. Furthermore, according to a back-ofthe-envelope calculation, the potential economic value of mangrove conservation, estimated in terms of fishery production reached 22,861 US$/hectare/year. This makes conservation substantially more cost-effective than alternative land uses, such as aquaculture and oil palm plantations. These findings highlight the need to support mangrove forest conservation to achieve sustainable development and ecosystem conservation

低環境負荷における高含水比粘土の改良及び評価方法に関する研究

長崎大学学位論文 学位記番号:博(工)甲第126号 学位授与年月日:令和5年3月20日Nagasaki University (長崎大学)課程博

リンパ球活性化に対する機械的ストレスの二相性効果

長崎大学学位論文 [学位記番号]博（医歯薬）甲第1527号 [学位授与年月日]令和5年3月20

観光と環境のカップリングに関する研究

長崎大学学位論文 [学位記番号]博（水・環）甲第91号 [学位授与年月日]令和5年2月15

トポイソメラーゼIIは汎アレナウイルス病に対する新規抗ウイルス薬の標的となり得る

Although many arenaviruses cause severe diseases with high fatality rates each year, treatment options are limited to off-label use of ribavirin, and a Food and Drug Administration (FDA)-approved vaccine is not available. To identify novel therapeutic candidates against arenaviral diseases, an RNA polymerase I-driven minigenome (MG) expression system for Lassa virus (LASV) was developed and optimized for high-throughput screening (HTS). Using this system, we screened 2595 FDA-approved compounds for inhibitors of LASV genome replication and identified multiple compounds including pixantrone maleate, a topoisomerase II inhibitor, as hits. Other tested topoisomerase II inhibitors also suppressed LASV MG activity. These topoisomerase II inhibitors also inhibited Junin virus (JUNV) MG activity and effectively limited infection by the JUNV Candid #1 strain, and siRNA knockdown of both topoisomerases (IIα and IIβ) restricted JUNV replication. These results suggest that topoisomerases II regulate arenavirus replication and can serve as molecular targets for panarenaviral replication inhibitors.長崎大学学位論文 学位記番号:博(医歯薬)甲第1523号 学位授与年月日:令和5年3月20日Author: Tosin Oladipo Afowowe, Yasuteru Sakurai, Shuzo Urata, Vahid Rajabali Zadeh, Jiro YasudaCitation: Viruses, 15(1), art. no. 105; 2022Nagasaki University (長崎大学)課程博

ミトコンドリア機能不全による加齢性疾患に対する海洋性カロテノイド類アスタキサンチンの効果に関する研究

長崎大学学位論文 学位記番号:博(水・環)甲第88号 学位授与年月日:令和5年3月20日Nagasaki University (長崎大学)課程博

チェンジエージェントとしての若者が近隣住民の主体的健康と幸福度におよぼす影響 -スリランカ・コロンボ市近郊におけるクラスター無作為化比較試験-

長崎大学学位論文 学位記番号:博(Global Health)甲第9号 学位授与年月日:令和5年3月2日Nagasaki University（長崎大学）課程博

蛍光及び化学発光反応を利用する揮発性有害物質の簡易分析法の開発

長崎大学学位論文 学位記番号:博(医歯薬)甲第1534号 学位授与年月日:令和5年3月20日Nagasaki University (長崎大学)課程博