Interview of Cassandra Baynard by McKenna Dunn and Daisy Roberts

Remote interview.Cassandra Baynard discusses her time at Ohio State as a student and member of the Black Student Union. This interview was one of 15 conducted by students in English 4567 (Rhetoric and Community Service) to capture as many stories as possible from former Ohio State students associated with the 1968 sit-in at the Administration Building (now Bricker Hall) that led to the arrests of 34 Black students, now known as the “OSU 34.” In addition to her experience at the sit-in, Williams also discusses her parents’ reaction to her arrest, and why it was important for the students to speak up that way. To view video recordings of 2018 interviews of four students talking about the events of 1968, please go to http://go.osu.edu/CarmenCollection1968

Baseline Biomarkers of Immune Checkpoint Inhibitor Clearance and Efficacy in Cancer Cachexia

Background: Cancer cachexia is a complex metabolic syndrome that is characterized by the loss of body weight, specifically skeletal muscle and adipose tissue. It leads to a lower quality of life and accounts for an estimated ~20% of cancer-related mortalities. Despite cancer cachexia’s impact on patient survival, it remains underrecognized and underdiagnosed. Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that target the body’s immune checkpoint proteins to stimulate the immune system to fight cancer. ICI therapy has vastly improved the treatment of certain cancers but only a limited number of patients respond. The reasons for this variable response are largely unknown but the rate of ICI clearance has been shown to be a predictor of response to ICI therapy. Also, clearance has been shown to coincide with some markers of cancer cachexia. This study aimed to determine baseline relationships among biomarkers of cachexia, ICI clearance, and ICI efficacy using clinical data from cancer patients. Identifying biomarkers that link cancer cachexia and ICI clearance to outcomes may help to increase our understanding of the relationships between cancer cachexia, elevated ICI clearance, and durable responses to ICIs. Methods: The study population is part of the ongoing non-interventional clinical trial, OSU20001. Data from 48 patients with either non-small cell lung cancer (n=37) or renal cell carcinoma (n=9), receiving pembrolizumab (n=28) or nivolumab (n=17) were analyzed which included computed tomography images, baseline clinical lab results and cytokine signatures taken at predetermined timepoints. Results: Baseline biomarkers of interest were analyzed by linear regression against lean mass index (LMI) and ICI baseline clearance (ICI CL). In ICI CL vs. biomarkers, IL-6 (p=0.024), albumin (p=0.038), ferritin (p=0.0084), and absolute monocyte count (p=0.0016) all gained significance. In LMI vs. biomarkers, adiponectin (p=0.022), absolute neutrophil count (p=0.022), and platelet (p=0.038) gained significance. In addition to linear regression, a survival with competing risk analysis was completed based on patient’s either receiving a nivolumab or pembrolizumab treatment. In patients with nivolumab, CC5a (p=0.032), CCL5 (p<0.001), SerpinE1 (p=0.001), CRP (p=0.01), Beta2m (p=0.002), pentraxin2 (p<0.001), Alpha2m (p=0.024), and absolute eosinophil count (p=0.007) were all significant with CCL5, SerpinE1, CRP, Alpha2m, and absolute eosinophil count would be thought to increase risk of death. In patients with pembrolizumab, the biomarkers that obtained a significant p-value were ICAM1 (p=0.019), Ferritin (p=0.049), TIMP1 (p=0.038), AST (p=0.02) and LDH (p=0.045) with ICAM, ferritin, and TIMP1 thought to increase risk of death. Conclusions: The IL-6 and albumin results agreed with previous literature findings as known markers of cachexia and clearance. There were several interesting results such as the significant relationships between BDNF, adiponectin, and platelet, and ICI CL or cachexia. Ferritin was the one biomarker that was associated with cachexia, ICI CL, and survival, suggesting that baseline ferritin could be a helpful biomarker in determining a patient’s response to ICI therapy. This new information could be helpful in determining the relationship between cancer patients, cachexia, and the variable response to ICI therapy.NIH National Cancer Institute grant R01CA273924No embargoAcademic Major: Biolog

Interview of Mike Williams by Olivia Dearth and Joseph Yuzwa

Remote interview.Mike Williams discusses his time at Ohio State as a student and member of the Black Student Union. This interview was one of 15 conducted by students in English 4567 (Rhetoric and Community Service) to capture as many stories as possible from former Ohio State students associated with the 1968 sit-in at the Administration Building (now Bricker Hall) that led to the arrests of 34 Black students, now known as the “OSU 34.” In addition to the sit-in, Williams also discusses the early development of the BSU at Ohio State and the differences between the sit-in in 1968 and the 1970 demonstrations. Williams also has an oral history interview conducted in 2018 that can be accessed here: http://hdl.handle.net/1811/87643. To view video recordings of 2018 interviews of Williams and three other students talking about the events of 1968, please go to http://go.osu.edu/CarmenCollection1968

The Moritz Briefing (January 2024)

An occasional newsletter highlighting recent activities and achievements of the Moritz Faculty

Cantonese Dialect-Writing and Korean Goyuhanja: Chinese Characters and Innovative Orthographic Creations

The Chinese writing system, spanning over three millennia, has enjoyed the longest, uninterrupted literary tradition in world history. At the same time, it had also impacted neighboring countries such as Korea, Japan, and Vietnam. However, the script is not static; time moves on. Some complex characters were later replaced by simpler forms or by forms that add phonetic cues. Some characters became obsolete and new ones were created, reflecting the standard, or national, language, and are entered into authoritative dictionaries for nation-wide distribution and consultation. Orthographic forms that are of regional origin may occasionally be included in such dictionaries but are explicitly marked as dialectal forms. This study analyzes the Sinitic graphs that were created by Cantonese and Korean speakers, focusing on the methods of creating the vernacular graphs in Cantonese and the Goyuhanja (固有漢字) graphs in Korean. Other related issues are also addressed

Sanctuary: Exclusion, Violence, and Indigenous Migrants in the East Bay

Citizenship, economies of exclusion, and tech money -- Decolonizing immigration with critical race theory -- Violence and the legacy of colonial genocide -- Sanctuary struggle, linguistic discrimination, and Indigenous displacement -- Volunteer literacy teacher counterstory -- Concluding a story without an end.Item embargoed for three year

The Erotic as Rhetorical Power: Archives of Romantic Friendship between Women Teachers

Introduction: The erotic as rhetorical power in the long nineteenth century -- Introduction to interludes: Imagined pasts beyond the archives -- A radical erotic of antislavery affection : abolitionist lecturing and freedmen's teaching, 1848-1893 -- Interlude 1: A school girl again -- A conservative erotic of emulating beauty : commonplace rhetorics and belletristic instruction, 1868-1900 -- Interlude 2: My husband -- A progressive erotic of sapphic egalitarianism : communication and leadership among equals, 1897-1922 -- Conclusion to interludes: Future archives -- Conclusion: Erotics of rhetorical power.Item embargoed for three year