Increased expression of interferon-stimulated gene 15 (ISG15) in cervical cells on day 14 of pregnancy in Holstein heifers

In cattle, expression of IFN-stimulated genes in the female reproductive tract has been reported as an early pregnancy diagnostic tool, as early as d 17 of pregnancy. The hypothesis of this study was that expression of ISG15 in the cervix of pregnant heifers is increased on d 14 of pregnancy. The objective was to compare the expression of ISG15 in cervical cells between pregnant and cyclic heifers (control, sham-inseminated) on d 14, 16, and 18 after insemination (d 0). Holstein heifers were submitted to an estrus synchronization protocol and inseminated with extender only (“control,” n = 6), or with regular semen (n = 15). Heifers were classified as pregnant (n = 10) by ultrasound at d 30 through the detection of a viable embryo with a heartbeat. Blood samples from the coccygeal vein were collected to determine serum progesterone concentrations on d 14, 16, and 18. The expression of ISG15 and PGR in cervical cells collected through cytobrush was measured on d 14, 16, and 18. A receiver operating characteristic (ROC) curve was calculated to quantify the pregnancy diagnostic accuracy of ISG15 and PGR expression. The expression levels of ISG15 in cervical cells were significantly greater in pregnant compared with control heifers on d 14, and remained greater on d 16 and 18, whereas differences in PGR were observed only on d 18. Scatter plots and ROC analyses showed the most accurate prediction of pregnancy for ISG15 on d 16. In conclusion, cervical cells express greater ISG15 mRNA in pregnant versus control heifers as early as d 14 postinsemination, with the best accuracy on d 16

Healthcare waste management at the Universidad de la República

El presente trabajo propone generar una reflexión sobre las debilidades, fortalezas y potencialidades de la gestión de los residuos de atención a la salud (RAS) en Uruguay, a partir del estudio de caso en el hospital universitario de la Universidad de la República (Udelar). Para esto, se toman como base algunos de los aspectos más importantes relevados por Ramírez (2022) durante la realización del diagnóstico de situación de la gestión intrainstitucional de RAS en el Hospital de Clínicas. En el marco de ese diagnóstico se realizó la caracterización cualitativa y cuantitativa de los RAS generados en las áreas del Hospital. Además, se elaboraron protocolos internos de gestión y guías de capacitación para ser utilizados en instancias de formación pertinentes, durante los procesos de implementación de dichos protocolos. A partir de los resultados obtenidos, se evidencian dificultades para determinación de tasas de generación de RAS y la importancia de la formación del funcionariado. A partir de esto, se proponen asuntos para la mejora de la gestión de RAS en los Centros de Atención a la Salud (CAS). En Udelar, cada Servicio Universitario en los que se generan RAS se encarga de su sistema de gestión. En cuanto a la formación, los estudiantes de las carreras del Área de Ciencias de Salud no cuentan con cursos vinculados con la gestión de los RAS generados en sus actividades profesionales. Por otro lado, como parte del Programa de Gestión Ambiental Universitaria de Udelar, se ofreció hasta el 2023 el curso “Gestión Intrainstitucional de Residuos Sanitarios en Udelar”, para todos los funcionarios.The goal of this work is to promote reflection on the weaknesses, strengths and potential of healthcare waste (HCW) management in Uruguay, based on a case study at the university hospital of Universidad de la República (Udelar). To this end, we draw on some of the most important aspects identified by Ramírez (2022) during the situational diagnosis of intra‑institutional HCW management at the Hospital de Clínicas. Within that diagnostic framework, we carried out a qualitative and quantitative characterization of the HCW generated in various hospital areas. In addition, internal management protocols and training guides were developed for use during training sessions relevant to the implementation of these protocols. The results reveal difficulties in determining HCW generation rates and underscore the importance of staff training. Accordingly, we propose actions to improve HCW management in healthcare centers. At Udelar, each university service at which HCW is generated is responsible for its own management system. Regarding training, students in health‑science degree programs are not offered courses related to the management of HCW generated in their professional activities. In contrast, as part of Udelar’s University Environmental Management Program, the course “Intra‑Institutional Healthcare Waste Management at Udelar” was offered to all staff until 2023

Audiometric database of academic musicians in Uruguay

This paper presents the results of an interdisciplinary study at the Universidad de la República (Uruguay), in which hearing loss is assessed in a group of academic musicians, including lyric singers, choristers, and orchestral musicians. Methods: Audiometric records from 137 academic musicians were analyzed. The Average Hearing Loss (PAM) methodology, based on Lafon and Duclos combined with the ISO 1999:2013 Standard, was used to convert all the registers to the hearing loss at the age of 35, which were then organized into a permanence curve and compared with reference curves from the ISO 1999:2013 Standard. Results and Conclusion: The results presented here are estimated to represent more than 27 % of the total population of adult academic musicians nationwide. The findings suggest that academic musicians in Uruguay are at a higher risk of noise-induced hearing loss than the general population in the ISO 1999:2013 Standard

Performance, construções de gênero e dissidência na dança vogue e na cultura de salão em Montevidéu

El movimiento autodenominado cultura ballroom es un movimiento cultural performático protagonizado por identidades LGBT (lesbianas, gays, bisexuales, trans/travestis/transgénero), en sus inicios principalmente trans afroamericanas y latinas. Uno de los motivos que originó el movimiento tiene que ver con la exclusión que recibían los colectivos afrodescendientes y latinos en los concursos de belleza donde participaban homosexuales que practicaban el transformismo drag (drag balls). Los eventos que construían tenían el formato de desfile de modas donde, según sus integrantes, se procuraba demostrar diversas habilidades que esta comunidad vinculaba con el transitar de las personas LGBT en-el-mundo generizadamente sexuado. El presente artículo procura exponer resultados de una investigación de corte etnográfico sobre el movimiento cultural ballroom en Uruguay junto al colectivo House of Polenta. El trabajo de investigación buscó comprender las formas en que se resignifica y re-apropia políticamente el movimiento cultura ballroom en este contexto. Primeramente, recorro algunas trayectorias de integrantes del colectivo vinculadas a la danza vogue. Por último, un análisis desde un enfoque de género sobre las categorías de competencia en esta performance cultural que brinda algunas claves para entender formas particulares y situadas que tiene el colectivo de comprender el género, el cuerpo y la sexualidad.The ballroom cultural movement is a performative movement led by lgbt identities, mainly Latin and African American in its origins. One of the reasons that gave rise to this movement was the marginalization of African descendants and Latin Americans in beauty pageants, which were led by homosexuals who practised dragqueen transformism (drag balls). These events mimicked the form of fashion runways in which participants aimed to demonstrate various social skills that this community believed lgbt people needed in order to fit into this sexually gendered word. This article aims to illustrate some of the findings of an ethnographic research on the ballroom culture movement in Uruguay, specifically the group House of Polenta. The research aimed to understand the ways in which this movement is politically reappropriated and resignified in this context. First, I cover some of the trajectories of the participants in the group and in the vogue dancing. Finally, I use a gender analysis to examine the categories of competition that this cultural performance uses, which I consider key to understanding particular forms of this group’s understanding of gender, body and sexuality.O movimento que se autodenomina cultural ballroom é um movimento cultural performativo com identidades LGBT (lésbicas, gays, bissexuais, trans/travestis/transgêneros), em seu início principalmente trans afro-americanos e latinos. Um dos motivos que originou o movimento tem a ver com a exclusão que grupos afrodescendentes e latinos recebiam em concursos de beleza onde participavam homossexuais que praticavam drag (drag balls). Os eventos que criaram tiveram o formato de um desfile de moda onde, segundo os seus membros, procuraram demonstrar diversas competências que esta comunidade vinculou ao percurso das pessoas LGBT no mundo género-sexuado. Este artigo busca apresentar os resultados de uma pesquisa etnográfica sobre o movimento cultural ballroom no Uruguai junto ao coletivo Casa da Polenta. O trabalho de pesquisa buscou compreender as formas como o movimento cultural ballroom é ressignificado e reapropriado politicamente nesse contexto. Primeiramente, revisarei algumas trajetórias de integrantes do coletivo ligado à dança de moda. Por fim, uma análise desde uma perspectiva de género sobre as categorias de competência nesta performance cultural que fornece algumas chaves para compreender as formas particulares e situadas que o colectivo tem de compreender o género, o corpo e a sexualidade

A quantitative systematic review on the analgesic efficacy and adverse effects of ketorolac in third molar surgery.

Objectives: This study aimed to determine the number needed to treat (NNT) of ketorolac in comparison to placebo after third molar surgery. Methods: Studies located in PubMed, Scopus, and Web of Science were evaluated with the Cochrane Risk of Bias assessment tool. Data on the onset of analgesia, the number of patients requiring rescue medication, the global or general evaluation of the study medication, and adverse effects were extracted. Data analysis was performed using Review Manager 5.3 software for Windows. Results: The qualitative assessment of the included studies showed that ketorolac was more effective than a placebo and the quantitative evaluation on the onset of analgesia (NNT = 1.6 (95%CIs = 1.4, 1.9), n = 301), the number of patients who took rescue analgesics (NNT = 3.6 (95%CIs = 2.8 to 4.9), n = 563), and the global evaluation of the treatments (NNT = 1.7 (95%CIs = 1.5 to 1.9), n = 475) showed estimates of analgesic efficacy with a statistical difference in favor of ketorolac when compared with a placebo. No statistical difference was observed in adverse effects between ketorolac and placebo (n = 739). Conclusions: There is scientific evidence of moderate quality that allows estimators of the analgesic efficacy of ketorolac to be calculated, which will significantly help the clinician who performs pharmacological treatment after third molar surgery

Hiperplasia endotelial papilar intravascular.

El presente estudio tuvo como objetivo contribuir a la literatura con un caso desafiante de una lesión asintomática que muestra un aspecto radiolúcido en la mandíbula, simulando un quiste residual. Una mujer de 60 años presentó una lesión en la mandíbula, detectada durante los exámenes de imagen. La Tomografía Computarizada reveló una lesión hipodensa con margen esclerótico de aproximadamente 0,8 x 0,8 x 0,7 cm en la región posterior derecha de la mandíbula. El principal diagnóstico diferencial fue un quiste residual y se realizó una biopsia excisional. El análisis microscópico reveló proyecciones papilares y trombos en el lumen del vaso revestido de endotelio. El análisis inmunohistoquímico fue positivo para CD34 y actina de músculo liso. Con base en estos hallazgos, la lesión fue identificada como hiperplasia endotelial papilar intravascular intraósea. Este informe de caso proporciona información sobre esta hipótesis potencial de radiolucencia unilocular ubicada en los huesos de la mandíbula.The present study aimed to add to the literature a challenging case of an asymptomatic lesion showing a radio- lucent aspect at the mandible mimicking a residual cyst. A 60-year-old woman presented a mandibular lesion, detecting during the imaging exams. Computed Tomography revealed a hypodense lesion with a sclerotic margin measuring about 0.8 x 0.8 x 0.7 cm on the right posterior mandible. The main differential diagnosis was a residual cyst, and an excisional biopsy was performed.Microscopic analysis revealed papillary projections and thrombi within the lumen of the vessel lined with endothelial. Immunohistochemical analysis was positive for CD34 and smooth muscle actin. Based on these findings, the lesion was identified as intraosseous intravascular pap- illary endothelial hyperplasia.This case report provides information about this potential hypothesis of unilocular radiolucency located in the jawbones.O presente estudo teve como objetivo contribuir para a literatura com um caso desafiador de uma lesão assinto- mática apresentando um aspecto radiolúcido, simulando um cisto residual. Uma mulher de 60 anos apresentou uma lesão na mandíbula, detectada incidentalmente durante exames de imagem. A Tomografia Computa- dorizada revelou uma lesão hipodensa com margem esclerótica medindo cerca de 0,8 x 0,8 x 0,7 cm na região posterior direita da mandíbula. O principal diagnóstico diferencial foi um cisto residual, e uma biópsia excisional foi realizada. A análise microscópica revelou projeções papilares e trombos no lúmen do vaso revestido por endotélio. A análise imuno-histoquímica foi positiva para CD34 e actina de músculo liso. Com base nesses achados, a lesão foi identificada como hiperplasia endotelial papilar intravascular intraóssea. Este relato de caso fornece informações sobre essa potencial hipótese de radiolucência unilocular localizada nos ossos gnáticos

Kinematics raw data of lateral walking at different speed

The dataset includes kinematics data recorded by a Motion Capture System (Vicon Motion System, Oxford, UK) at 100Hz. Data were filtered (fourth-order zero-lag Butterworth low-pass filter with a cutoff frequency of 6 Hz) and exported with Vicon’s Nexus 2.15 software. LW_kinematics_data (JSON Dataset) This dataset contains gait cycle data collected across 24 subjects, lateral walking speeds, and directions. The data is stored as a hierarchical JSON file for ease of parsing, analysis, and expansion. --- Structure The data is organized in four hierarchical levels: Subject ID → Direction → Speed → Cycle Number → Kinematic Variables (markers 3D position) Where: - **Subject ID**: A numeric string (e.g., `"7"`), - **Direction**: `"Left"` or `"Right"`, indicated the direction of lateral movement - **Speed**: Integer string representing the gait speedin hm/h (e.g., `"18"` means 1.8 km/h). Speed values can be easily converted to m/s by dividing for 36 (e.g. 18/36 = 0.5 m/s). - **Cycle Number**: A string ID for each gait cycle (e.g., `"1"`, `"26"`, etc.) Each cycle entry contains a dictionary of 55 sampled variables over time: Frame is an index var - The following variables are grouped by three, and named as right or left (R, L) + the name of the body marker + the axis (e.g. RLOBx, RLOBy, RLOBz, for a total of 9 anatomical positions and 18 markers). LOB = Temporal lobe SH = Acromion ELB = Elbow WR = Ulnar stiloyd process GT = Great Trochanter KN = Knee (lateral) AN = Malleolus lateral HEE = Heel MT = 5th Metatarsal The 3D sapece were calibrated following the right hand rule, with the axis "X" = mediolateral; "Y" = anteroposterior; "Z" = vertical. Values are in mm. --- Example { "7": { "Left": { "45": { "26": { "RLOBx": [61.44, 61.92, 60.88, ...], "RLOBy": [56.09, 56.09, 54.58, ...], ... } } } } } </html

Distúrbio hemorrágico raro em uma família uruguaia. Deficiência congênita de α2-antiplasmina em dois irmãos

El déficit congénito de α2-antiplasmina (α2AP) es un desorden hemorrágico muy infrecuente dado por una alteración en la fibrinólisis. Presentamos los casos clínicos de dos hermanos con déficit congénito de α2AP.Congenital α2-antiplasmin (α2AP) deficiency is a very rare bleeding disorder caused by impaired fibrinolysis. We present the clinical cases of two brothers with congenital α2AP deficiency.A deficiência congênita de α2-antiplasmina (α2AP) é um distúrbio hemorrágico muito raro causado por fibrinólise prejudicada. Apresentamos os casos clínicos de dois irmãos com deficiência congênita de α2AP

Faccionalismo, correlações de força e conflito no PIT-CNT (1983-2023)

El artículo describe, sintetiza y analiza las dinámicas del conflicto interno en la principal organización sindical uruguaya, el Plenario Intersindical de Trabajadores-Convención Nacional de Trabajadores (PIT-CNT), entre 1983 y 2023. Se establecen tres etapas históricas principales de conflicto, a cada una de las cuales corresponde una determinada estructura de faccionalismo que ordena la discusión interna, caracterizando a los diferentes grupos que compiten por la representación del conjunto de los trabajadores, sus discursos, identidades y relaciones mutuas. Se concluye afirmando la existencia de fisuras básicas que producen identidades y dinámicas de competencia interna en distintos períodos, relevando el cambio y continuidad en el rol de los partidos políticos en dicho ordenamiento.This article describes, synthesizes and analyzes the dynamics of the internal conflict in the main Uruguayan trade union organization, the Plenario Intersindical de Trabajadores-Convención Nacional de Trabajadores (PIT-CNT), between 1983 and 2023. Three main historical stages of conflict are established, each of which corresponds to a certain structure of factionalism that orders the internal discussion, characterizing the different groups that compete for the representation of the group of workers, their discourses, identities and mutual relations. It concludes by affirming the existence of basic fissures that produce identities and dynamics of internal competition in different periods, highlighting the change and continuity in the role of political parties in said order.Este artigo descreve, sintetiza e analisa a dinâmica do conflito interno na principal organização sindical uruguaia, o Plenario Intersindical de Trabajadores-Convención Nacional de Trabajadores (PIT-CNT), entre 1983 e 2023. Três principais etapas históricas do conflito são estabelecidas, a cada um dos quais corresponde uma determinada estrutura de faccionalismo que organiza a discussão interna, caracterizando os diferentes grupos que competem pela representação do grupo de trabalhadores, seus discursos, identidades e relações mútuas. Conclui afirmando a existência de fissuras basicas que produzem identidades e dinâmicas de competição interna em diferentes períodos, destacando a mudança e a continuidade do papel dos partidos políticos nessa ordem

UruDendro, a public dataset of 64 cross-section images and manual annual ring delineations of Pinus taeda L.

The automatic detection of tree-ring boundaries and other anatomical features using image analysis has progressed substantially over the past decade with advances in machine learning and imagery technology, as well as increasing demands from the dendrochronology community. This paper presents a publicly available dataset of 64 annotated images of transverse sections of commercially grown Pinus taeda L. trees from northern Uruguay, presenting 17 to 24 annual rings. The collection contains several challenging features for automatic ring detection, including illumination and surface preparation variation, fungal infection (blue stains), knot formation, missing bark or interruptions in outer rings, and radial cracking. This dataset can be used to develop and test automatic tree ring detection algorithms. The dataset presented here was used to develop the Cross-Section Tree-Ring Detection (CS-TRD) method, an open-source automated ring-detection algorithm for cross-sectioned images. Dataset access at https:// doi. org/ 10. 5281/ zenodo. 15110 647. Access to the metadata describing the data set : https:// metad ata- afs. nancy. inra. fr/ geone twork/ srv/ fre/ catal og. searc h#/ metad ata/ 5fdbd 411- 9ae1- 4ce6- 8ef0- cdfa2 fbd7a 6a.Proyecto ANII-FMV-176061: UruDendro 2.0: Aplicación de técnicas de procesamiento de imágenes e inteligencia artificial para la dendrometría automática de especies de madera nativas y comerciales.Projecto ANII ART_X_2021_1_170389 : Detección temprana de madera de compresión en pino para una mayor eficiencia industrial.https://annforsci.biomedcentral.com/articles/10.1186/s13595-025-01296-