A characterization of heaviness in terms of relative symplectic cohomology

AbstractFor a compact subset of a closed symplectic manifold , we prove that is heavy if and only if its relative symplectic cohomology over the Novikov field is nonzero. As an application, we show that if two compact sets are not heavy and Poisson commuting, then their union is also not heavy. A discussion on superheaviness together with some partial results is also included.</jats:p

Closed form solution to zero coupon bond using a linear stochastic delay differential equation

We present a short rate model that satisfies a stochastic delay differential equation. The model can be considered a delayed version of the Merton model (Merton 1970, 1973) or the Vasi\v{c}ek model (Vasi\v{c}ek 1977). Using the same technique as the one used by Flore and Nappo (2019), we show that the bond price is an affine function of the short rate, whose coefficients satisfy a system of delay differential equations. We give an analytical solution to this system of delay differential equations, obtaining a closed formula for the zero coupon bond price. Under this model, we can show that the distribution of the short rate is a normal distribution whose mean depends on past values of the short rate. Based on the results of K\"uchler and Mensch (1992), we prove the existence of stationary and limiting distributions

Home-based multi-sensory and proximal strengthening program to improve balance in Charcot–Marie–Tooth disease type 1A: a proof of concept study

Introduction/Aims People with Charcot–Marie–Tooth Disease (CMT) frequently report problems with balance, which lead to an increased risk of falls. Evidence is emerging of training interventions to improve balance for people with CMT, but to date all have relied on clinic-based treatment and equipment. This proof-of-concept study explored whether a multi-modal program of proprioceptive rehabilitation and strength training can be delivered at home, to improve balance performance in people with CMT Type 1A. Methods Fourteen participants with CMT Type 1A were recruited into this randomized, two-arm study. Baseline assessments included measures of disease severity, posturography, physical function, and patient-reported outcome measurements. All participants received one falls education session. Participants were randomized to either 12 weeks of balance training or 12 weeks of usual activities. The intervention comprised a home-based, multi-sensory balance training and proximal strengthening program, supported by three home visits from a physiotherapist. Results Thirteen participants completed the study. The intervention was successfully implemented and well tolerated, with high participation levels. Functional measures of balance and walking showed strong effect sizes in favor of the training group. Posturography testing demonstrated moderate improvements in postural stability favoring the intervention group. Inconsistent changes were seen in lower limb strength measures. Discussion The intervention was feasible to implement and safe, with some evidence of improvement in balance performance. This supports future studies to expand this intervention to larger trials of pragmatic, home-delivered programs through current community rehabilitation services and supported self-management pathways

Phage biocontrol success of bacterial wilt depends on synergistic interactions with resident rhizosphere microbiota

Phages can successfully be used in vitro and in planta to biocontrol the phytopathogenic Ralstonia solanacearum bacterium - the causal agent of bacterial wilt disease. However, phage biocontrol outcomes are still variable, and it is unclear what causes this. In this study, we assessed the efficiency of four phages in controlled in vitro and in planta experiments in all 1- and 2-phage combinations. We found that using phages in combination did not improve the phage biocontrol efficiency relative to single phage treatments, while certain phages and their combinations were more effective than the others. High intra-treatment variability in phage efficiency was observed across all phage treatments, which was associated with clear shifts in microbiome composition, a reduction in R. solanacearum and an increase in phage densities. We further identified the bacterial taxa that were associated with these ‘shifted’ microbiomes and conducted additional plant growth experiments, demonstrating that some of the enriched bacterial species could protect plants from R. solanacearum infections – a pattern which was also observed using partial least squares path modelling (PLS-PM). Together, these results suggest that phages could open niche space for beneficial bacteria by reducing pathogen densities, and that variability in phage biocontrol outcomes is rhizosphere microbiome-dependent, which can introduce between-replicate variation, even in controlled greenhouse conditions

Relational conflicts during COVID-19: Impact of loss and reduction of employment due to prevention measures and the influence of sex and stress (in the iCARE study).

This study explored the association between pandemic-related loss/reduction of employment, sex, COVID-19-related stress and relational conflicts. A sample of 5103 Canadians from the iCARE study were recruited through an online polling firm between October 29, 2020, and March 23, 2021. Logistic regressions revealed that participants with loss/reduction of employment were 3.6 times more likely to report increased relational conflicts compared to those with stable employment (OR = 3.60; 95% CIs = 3.03-4.26). There was a significant interaction between employment status and sex (x2 = 10.16; p < 0.005), where loss/reduction of employment was associated with more relational conflicts in males compared to females. There was a main effect of COVID-19-related stress levels on relational conflicts (increased stress vs no stress : OR = 9.54; 95% CIs = 6.70-13.60), but no interaction with loss/reduction of employment (x2 = 0.46, p = 0.50)

Exploring Religious Practice in Crisis:A non-Western tension-centred approach to meaningful work

This study develops a religious practice(s) approach to explore the tensional nature and process of meaningful work. We first problematize existing workplace spirituality approaches to management and organization studies (MOS) generally and meaningful work specifically. Our focus is the individual-organizational and positive-critical divides and overlooked tensions and in-betweenness within these divides. We propose a religious practice(s) approach as an alternative lens to address this in-betweenness, drawing on the theory and practices of Buddhist emptiness to theorize meaningful work as a tensional process unfolding at the intersection between the gaining and losing of meaningfulness. We explore this tensional in-betweenness empirically through 51 in-depth, semi-structured interviews with Buddhist practitioners on their lived experiences of meaningful work during the Covid-19 pandemic. Our findings reveal two realization processes that manifest the tensional in-betweenness of meaningful work during the Covid-19 pandemic, and which entrap and emancipate individuals in their pursuit of meaningful work. Our contribution is threefold. First, we develop a religious practice(s) approach to MOS by addressing the existing divides in workplace spirituality perspectives and the resulting overlooked tensions inherent in experiencing meaningful work. In doing so, we also extend the existing understanding of ‘tension’ in meaningful work, which has predominantly been treated as self-evidential and not yet fully integrated into the theorization of meaningful work. Third, we move away from the over-reliance on Western-centred theories through contextualized theory-building. This, we hope, will develop non-Western theorization in MOS and in turn prompt a more enriched, multidimensional understanding of meaningful work

Risk factors for raised left ventricular filling pressure by cardiovascular magnetic resonance: Prognostic insights

Background Cardiovascular magnetic resonance (CMR) imaging shows promise in estimating pulmonary capillary wedge pressure (PCWP) non-invasively. At the population level, the prognostic role of CMR-modelled PCWP remains unknown. Furthermore, the relationship between CMR-modelled PCWP and established risk factors for cardiovascular disease has not been well characterized. Objective The main aim of this study was to investigate the prognostic value of CMR-modelled PCWP at the population level. Methods Employing data from the imaging substudy of the UK Biobank, a very large prospective population-based cohort study, CMR-modelled PCWP was calculated using a model incorporating left atrial volume, left ventricular mass and sex. Logistic regression explored the relationships between typical cardiovascular risk factors and raised CMR-modelled PCWP (≥15 mmHg). Cox regression was used to examine the impact of typical risk factors and CMR-modelled PCWP on heart failure (HF) and major adverse cardiovascular events (MACE). Results Data from 39 163 participants were included in the study. Median age of all participants was 64 years (inter-quartile range: 58 to 70), and 47% were males. Clinical characteristics independently associated with raised CMR-modelled PCWP included hypertension [odds ratio (OR) 1.57, 95% confidence interval (CI) 1.44–1.70, P < 0.001], body mass index (BMI) [OR 1.57, 95% CI 1.52–1.62, per standard deviation (SD) increment, P < 0.001], male sex (OR 1.37, 95% CI 1.26–1.47, P < 0.001), age (OR 1.33, 95% CI 1.27–1.41, per decade increment, P < 0.001) and regular alcohol consumption (OR 1.10, 95% CI 1.02–1.19, P = 0.012). After adjusting for potential confounders, CMR-modelled PCWP was independently associated with incident HF [hazard ratio (HR) 2.91, 95% CI 2.07–4.07, P < 0.001] and MACE (HR 1.48, 95% CI 1.16–1.89, P = 0.002). Conclusions Raised CMR-modelled PCWP is an independent risk factor for incident HF and MACE. CMR-modelled PCWP should be incorporated into routine CMR reports to guide HF diagnosis and further management

Exit Game with Private Information

The timing of strategic exit is one of the most important but difficult business decisions, especially under competition and uncertainty. Motivated by this problem, we examine a stochastic game of exit in which players are uncertain about their competitor’s exit value. We construct an equilibrium for a large class of payoff flows driven by a general one-dimensional diffusion. In the equilibrium, the players employ sophisticated exit strategies involving both the state variable and the posterior belief process. These strategies are specified explicitly in terms of the problem data and a solution to an auxiliary optimal stopping problem. The equilibrium that we obtain is further shown to be unique within a wide subclass of symmetric Bayesian equilibria

The spectrum of systemic sclerosis-associated pulmonary hypertension: Insights from the ASPIRE registry

Background There are limited data assessing the spectrum of systemic sclerosis-associated pulmonary hypertension (PH). Methods Data for 912 systemic sclerosis patients assessed between 2000 and 2020 were retrieved from the Assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre (ASPIRE) registry and classified based on 2022 European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines and multimodality investigations. Results Reduction in pulmonary vascular resistance (PVR) diagnostic threshold to >2 WU resulted in a 19% increase in precapillary PH diagnoses. Patients with PVR ≤2 WU had superior survival to PVR >2–3 WU which was similar to PVR >3–4 WU. Survival in pulmonary arterial hypertension (PAH) was superior to PH associated with lung disease. However, patients with mild parenchymal disease on CT had similar characteristics and outcomes to patients without lung disease. Combined pre- and postcapillary PH had significantly poorer survival than isolated postcapillary PH. Patients with mean pulmonary arterial wedge pressure (PAWP) 13–15 mm Hg had similar haemodynamics and left atrial volumes to those with PAWP >15 mm Hg. Unclassified-PH had more frequently dilated left atria and higher PAWP than PAH. Although Unclassified-PH had a similar survival to No-PH, 36% were subsequently diagnosed with PAH or PH associated with left heart disease. The presence of 2–3 radiological signs of pulmonary veno-occlusive disease was noted in 7% of PAH patients and was associated with worse survival. Improvement in incremental shuttle walking distance of ≥30 m following initiation of PAH therapy was associated with superior survival. PAH patients diagnosed after 2011 had greater use of combination therapy and superior survival. Conclusion A number of systemic sclerosis PH phenotypes can be recognized and characterized using haemodynamics, lung function and multimodality imaging

Variation in cystectomy pathology reporting practice—results from an international survey of 212 pathologists

The pathological assessment of cystectomy specimens is important for accurate prognostic information and to inform adjuvant therapy decisions. However, there is limited evidence regarding the best approach to fixation, dissection, block selection and microscopic assessment of cystectomies. We report the results of an international survey of 212 pathologists and their approach to cystectomy pathology. There is variation at all stages of the specimen journey including in fixation and dissection techniques, and in the approach to evaluating residual tumour. This is particularly evident in the post-neoadjuvant chemotherapy setting where there is variable use of response scoring systems and differing approaches to sampling. We also find variation in the use of digital and molecular pathology in cystectomy specimens. Finally, we have suggested areas for future research in cystectomy pathological assessment