Mechanism of osteogenic differentiation of umbilical cord mesenchymal stem cells

Mesenchymal stem cells (MSCS) exist in a variety of tissues and have multi-lineage differentiation potential. Mesenchymal stem cells have great application prospects in the treatment of bone injury diseases. The rapid initiation and efficient induction of osteogenic signaling pathways are the key to mesenchymal stem cell-based bone tissue engineering technology. Multiple signaling pathways have been confirmed to play a regulatory role in the process of osteogenic differentiation of mesenchymal stem cells. This article reviews the research progress of the mechanism of osteogenic differentiation of mesenchymal stem cells

The Impact of Energy Level Zoning Nursing Mode on the Emergency Response Effect of Critically Ill Patients

Objective: To improve the emergency response effect of critically ill patients, and to implement a level zoning nursing model in clinical practice to clarify its impact on critically ill patients. Methods: A total of 95 critically ill patients who received diagnosis and treatment in the hospital during the period of January 2023 to December 2023 were analyzed. They were divided into a control group (49 cases) and an observation group (46 cases) in order of diagnosis and treatment. Two groups of nursing interventions were implemented using conventional methods and level based nursing models, and the intervention situation was analyzed. In terms of the incidence of complications, the observation group had a lower total value (

Mesenchymal stem cells secretions for treating neurological diseases and their mechanism of action

Neurological diseases are a class of diseases that seriously affect human health, including stroke, Parkinson’s disease, Alzheimer’s disease and spinal cord injury. Traditional treatments have some limitations in the treatment of these diseases, such as drug side effects, surgical risks, etc. In recent years, secretions from mesenchymal stem cells (MSCs) have attracted much attention as a new method to treat neuro_x005flogical diseases. The secretions are composed of a variety of bioactive components, which can exert their therapeutic effects by regulating the inflammatory response, promoting the regeneration and repair of nerve cells, and resisting oxidative stress. This review aims to review the application of MSC secretions in the treatment of neurological diseases and explore the mechanism of action

Contributions of Integration of Traditional Chinese and West_x005fern Medicine to the Prevention and Treatment of Respiratory Diseases

Respiratory disease is a relatively common disease currently recognized in society, which brings a burden to individuals and society that beyond measure. The Integration of traditional Chinese medicine (TCM) and Western medicine(WM) to prevent and treat respiratory diseases is a new method of comprehensive application of TCM and WM for prevention and treatment. Its advantage point in the treatment of respiratory diseases have become increasingly prominent, becoming one of the important measures in the field of disease control Nowadays. Integration of TCM and WM(ITCWM) brings a more effective and sustainable approach to the prevention and treatment of respiratory diseases and alleviates the pain and suffering of patients during treatment. The contribution of ITCWM to the prevention and treatment of respiratory diseases is not only reflected in treatment, but also in prevention, health-care and health education. This article will explore the particular contribution of ITCWM in the prevention and treatment of respiratory diseases in the disease control and human well-being

Application of novel oral anticoagulants for the antithrombotic effect of cardiovascular system diseases

Long-term oral anticoagulant is one of the methods for the treatment of cardiovascular system diseases, and the most widely used anticoagulant drug is warfarin, but its clinical application has been greatly limited due to its slow onset, easy to affect by various factors, and difficult dose control. In recent years, with the continuous in-depth research on cardiovascular system diseases, the emergence of new oral anticoagulants (NOAC) has greatly impacted the status of traditional anticoagulant warfarin because of its safety, stability and convenience of consumption. The purpose of this article is to review the classification and application of novel oral anticoagulants

Immunoinflammatory mechanism of severe pneumonia and the application of inflammatory markers in clinical practice

Pneumonia is a common disease and one of the leading causes of morbidity and mortality worldwide. [1] Severe pneumonia is a unique clinical disease that is highly life-threatening, characterized by severe sepsis, septic shock, or respiratory failure. Usually, treatment is required in the intensive care unit (ICU). Approximately 10% of community-acquired pneumonia (CAP) patients require hospitalization, with a mortality rate of 21% -47%. Most patients with severe community-acquired pneumonia have complications, including chronic obstructive pulmonary disease, diabetes and coronary heart disease. Streptococcus pneumoniae, Staphylococcus aureus, Mycoplasma pneumoniae, aaLe_x005fgionella, Klebsiella pneumoniae, Haemophilus influenzae, novel coronavirus, respiratory virus and Pseudomonas aeruginosa are important pathogenic microorganisms for severe CAP. [2] Host autoimmune factors, patient clinical manifestations, and laboratory and imaging examination results at admission can help identify high-risk populations for this disease. Early identification and timely empirical application of antibiotics are particularly important for the prognosis of patients

Research Progress on the effect of High altitude and hypoxia on Mitochondrial function in Obesity

Obesity is one of the diseases that threaten human health at present, and it can lead to the increasing prevalence of related complications, such as Insulin resistance, Non-alcoholic fatty liver diseases NAFLD and Type 2 diabetes mellitus and so on. In the whole world, the prevalence rate of obesity is on the rise. Insulin resistance is one of the most common complications of obesity. More and more studies have shown that there is a close relationship between mitochondrial dysfunction and insulin resistance. Skeletal muscle is an important target organ of insulin. Skeletal muscle mitochondrial dysfunction can lead to abnormal glucose and lipid metabolism and further affect the signal pathway of energy metabolism. The new epidemiological survey shows that the prevalence of obesity in high altitude areas is significantly lower than that in plain areas, and the prevalence of overweight and obesity is negatively correlated with altitude. This paper discusses the relationship between high altitude hypoxia and mitochondrial metabolism

Correlation Study between Genetic Polymorphisms and Blood Concentrations of Sodium Valproate in Pediatric Epilepsy Patients

Objective: To explore the correlation between genetic polymorphisms and blood concentrations of sodium valproate in pediatric epilepsy patients, providing evidence for individualized treatment of epilepsy patients. Methods: Pediatric epilepsy patients diagnosed with epilepsy and treated with sodium valproate monotherapy in the outpatient and inpatient departments of a tertiary hospital from January 2020 to December 2023 were selected. The steady-state blood concentrations of sodium valproate were monitored, and polymerase chain reaction (PCR) was used to genotype ABCB1G2677T/A and UGT1A6T19G genes. Data were analyzed using SPSS 17.0 statistical software. Results: The UGT1A6T19G gene polymorphism significantly affected the blood concentrations of sodium valproate in epilepsy patients. Carriers of the G allele had significantly lower blood concentrations of sodium valproate than wild-type homozygotes (TT) patients, and the decrease in blood concentrations of sodium valproate was particularly significant in homozygous mutant GG genotype patients. The ABCB1G2677T/ A gene polymorphism had no statistically significant effect on the blood concentrations of sodium valproate in pediatric epilepsy patients. Conclusion: Through the study of the correlation between genetic polymorphisms and blood concentrations of sodium valproate, factors in_x0002_fluencing the steady-state trough concentrations of valproate can be revealed from a genetic perspective, providing theoretical evidence for the precise use of sodium valproate in pediatric epilepsy patients

Risk factors for ventilator-associated pneumonia in ICU me_x005fchanically ventilated patients: a meta-analysis

Objective: This study aims to determine the risk factors for the development of ventilator-associated pneumonia (VAP) in ICU mechanically ventilated patients through meta-analysis. Method: Conduct a comprehensive search of multiple domestic and international databases, collect literature on the risk factors of VAP in ICU patients from November 2023, and conduct meta-analysis using RevMan5.4 software. Result: 31 high-quality studies were included, and it was found that age, COPD history, position, APACHE II score, antibiotic combination, repeated tracheal intubation, tracheostomy, indwelling gastric tube, mechanical ventilation time, and ICU hospitalization time were significantly associated with an increased risk of VAP; However, consciousness disorders and hypoalbuminemia do not show a signifi_x005fcant correlation with the risk of VAP. Conclusion: Specific patient characteristics and clinical procedures are associated with increased risk of VAP, and clinical attention should be paid to these risk factors in order to intervene early to prevent VAP and improve patient prognosis

The value of CRP and NLR in differential diagnosis of benign and malignant pulmonary nodules

Objective: Evaluate CRP and NLR levels in benign vs. malignant pulmonary nodules for differential diagnosis. Methods: Selected 60 patients with benign nodules and 60 with lung cancer from a Hunan hospital from August 2022 to December 2023. Analyzed CRP and NLR diagnostic value. Results: Significant differences in CRP, NLR levels between groups (