Solo Fathers and Mothers: An Exploration of Well-Being, Social Support and Social Approval

Research has begun to explore the experiences of single mothers by choice who choose to start a family alone and do so using donated gametes. However, very little is known about the experiences of single fathers by choice, and even less is known about how their experiences might compare to mothers in the same position. This exploratory study of single mothers (n = 19) and fathers (n = 17) by choice examined mental health and social support among mothers who used sperm donation, and fathers who used egg donation and surrogacy, to become parents. Data relating to their reasoning for pursuing solo parenthood, mental health, and social support were analyzed quantitatively. To further explore fathers’ experiences of being a solo parent, a thematic analysis was conducted exploring their descriptions of social responses to their family type. Regarding parental mental health, no statistically significant differences were found between mothers and fathers, and both groups of parents had sought out supportive networks, both before becoming a parent, and as a single parent. Fathers’ responses indicated that they received both supportive and negative reactions, although they generally perceived the majority of interactions to be positive. However, frequent references made by members of the public, or by the media, to their family type being new or different served to reproduce social scripts about normative family types. The study findings, despite the small sample size, contribute to a new understanding of the well-being and experiences of both mothers and fathers who choose to start their family and parent alone.</p

Addiction medicine in modern contexts: hot topics from around the globe

Addiction is a chronic yet treatable disorder. Patterns of addiction, whether substance related or behavioural, vary among countries and regions. Addiction medicine practice and approaches used in management are not only different from one country to another but are influenced by other factors, including environmental ones. The COVID-19 pandemic is one of the major environmental changes that had an impact on addiction. In this editorial, light will be shed on three articles covering recent updates in addiction medicine, ranging from types of substances and service provision to inclusion of gaming disorder in ICD-11.</p

Dityrosine cross-linking and its potential roles in Alzheimer’s disease

Oxidative stress is a significant source of damage that accumulates during aging and contributes to Alzheimer’s disease (AD) pathogenesis. Oxidation of proteins can give rise to covalent links between adjacent tyrosines known as dityrosine (DiY) cross-linking, amongst other modifications, and this observation suggests that DiY could serve as a biomarker of accumulated oxidative stress over the lifespan. Many studies have focused on understanding the contribution of DiY to AD pathogenesis and have revealed that DiY crosslinks can be found in both Aβ and tau deposits – the two key proteins involved in the formation of amyloid plaques and tau tangles, respectively. However, there is no consensus yet in the field on the impact of DiY on Aβ and tau function, aggregation, and toxicity. Here we review the current understanding of the role of DiY on Aβ and tau gathered over the last 20 years since the first observation, and discuss the effect of this modification for Aβ and tau aggregation, and its potential as a biomarker for AD.</p

Non-perturbative non-Gaussianity and primordial black holes

We present a non-perturbative method for calculating the abundance of primordial black holes given an arbitrary one-point probability distribution function for the primordial curvature perturbation, . A non-perturbative method is essential when considering non-Gaussianities that cannot be treated using a conventional perturbative expansion. To determine the full statistics of the density field, we relate ζ to a Gaussian field by equating the cumulative distribution functions. We consider two examples: a specific local-type non-Gaussian distribution arising from ultra slow roll models, and a general piecewise model for with an exponential tail. We demonstrate that the enhancement of primordial black hole formation is due to the intermediate regime, rather than the far tail. We also show that non-Gaussianity can have a significant impact on the shape of the primordial black hole mass distribution.</p

Documenting Families: Paper-Work in Family Display among Planned Single Father Families

This article extends existing sociological scholarship on doing and displaying family by developing the concept of documenting families. We suggest that documenting is conceptually rich insofar as it showcases the relationship, and tensions, between institutional practices and individual experiences of family display. Drawing on our research with men who became parents without partners, we argue that the process of documenting family is made especially evident in studies of what Finch originally referred to as ‘non-conventional’ family relationships. We explain that documenting sheds light not only on the official and unofficial means through which families are recognised on paper, but also on family practices as work – in this case paper-work – that involves negotiation between different social actors who are generally unequal in terms of their authority and agency to impose situational meaning.</p

Guideline for Civil Society Organizations in the Management and Monitoring of Proceeds of Crime

This manual is a guide for Civil Society Organizations (CSOs) to monitor and manage proceeds of crime. It draws on CLEEN Foundation's monitoring experience under the 2020 Trilateral Asset Return Agreement to provide insights and lessons acquired from the agreement's implementation. It covers international, regional, and domestic legal mandates for CSO participation, engagement strategies and best practices for transparent and accountable management while contributing to Sustainable Development Goals, particularly 16.4 and 16.5. The manual underscores the significant impact of CSOs' work in communities, inspiring them to engage in asset recovery and collaborating with other stakeholders to deprive criminals of their illicit gains and return assets to their rightful owners</p

Introduction to June’s theme: Parenting

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Towards a relational sociology of retrofit

Decarbonisation of residential buildings (‘retrofit’) is vital if nations are to meet declared net zero targets. This challenge is especially acute in the UK, which has some of the least energy efficient homes in Europe. Yet, to date, sociology has paid relatively little attention either to the urgency of this challenge or to its potential solutions. This article uses concepts from relational sociology to propose a complete reframing of the retrofit challenge and concludes by offering suggestions to improve energy policy design and incentives. It opens new avenues for sociologically driven research into how and why people ‘retrofit’ their homes, highlighting dynamics of trust, power and emotion as meaningful barriers to retrofit at scale. We conclude that the multiple stakeholders seeking to boost energy efficiency interventions in homes should focus less upon economic incentives for ‘rational actors’ and more upon reducing, facilitating and smoothing the ‘relational work’ needed to deliver retrofit.</p

Estimates of the mutation rate per year can explain why the molecular clock depends on generation time

Rates of molecular evolution are known to vary across species, often deviating from the classical expectation of a strict molecular clock. In many cases, the rate of molecular evolution has been found to correlate to generation time, an effect that could be explained if species with shorter generation times have higher mutation rates per year. We investigate this hypothesis using direct estimates of the mutation rate for 133 eukaryotic species from diverse taxonomic groups. Using a phylogenetic comparative approach, we find a strong negative correlation between mutation rate per year and generation time, consistent across all phylogenetic groups. Our results provide a simple explanation for why generation time plays a pivotal role in driving rates of molecular evolution across eukaryotes.</p

Injecting network structure determines the most efficient strategy to achieve Hepatitis C elimination in people who inject drugs

Transmission of Hepatitis C (HCV) continues via sharing of injection equipment between people who inject drugs (PWID). Network-based modelling studies have produced conflicting results about whether random treatment is preferable to targeting treatment at PWID with multiple partners. We hypothesise that differences in the modelled injecting network structure produce this heterogeneity. The study aimed to test how changing network structure affects HCV transmission and treatment effects. We created three dynamic injecting network structures connecting 689 PWID (UK-net, AUS-net and USA-net) based on published empirical data. We modelled HCV in the networks and at 5 years compared prevalence of HCV 1) with no treatment, 2) with randomly targeted treatment and 3) with treatment targeted at PWID with the most injecting partnerships (degree-based treatment). HCV prevalence at 5 years without treatment differed significantly between the three networks (UK-net (42.8%) vs. AUS-net (38.2%), p </p