Designing probiotic therapies with broad-spectrum activity against a wildlife pathogen

Host-associated microbes form an important component of immunity that protect against infection by pathogens. Treating wild individuals with these protective microbes, known as probiotics, can reduce rates of infection and disease in both wild and captive settings. However, the utility of probiotics for tackling wildlife disease requires that they offer consistent protection across the broad genomic variation of the pathogen that hosts can encounter in natural settings. Here we develop multi-isolate probiotic consortia with the aim of effecting broad-spectrum inhibition of growth of the lethal amphibian pathogen Batrachochytrium dendrobatidis (Bd) when tested against nine Bd isolates from two distinct lineages. Though we achieved strong growth inhibition between 70 and 100% for seven Bd isolates, two isolates appeared consistently resistant to inhibition, irrespective of probiotic strategy employed. We found no evidence that genomic relatedness of the chytrid predicted similarity of inhibition scores, nor that increasing the genetic diversity of the bacterial consortia could offer stronger inhibition of pathogen growth, even for the two resistant isolates. Our findings have important consequences for the application of probiotics to mitigate wildlife diseases in the face of extensive pathogen genomic variation

Equilibrium states and their entropy densities in gauge-invariant C*-systems

A gauge-invariant C*-system is obtained as the fixed point subalgebra of the infinite tensor product of full matrix algebras under the tensor product unitary action of a compact group. In the paper, thermodynamics is studied on such systems and the chemical potential theory developed by Araki, Haag, Kastler and Takesaki is used. As a generalization of quantum spin system, the equivalence of the KMS condition, the Gibbs condition and the variational principle is shown for translation-invariant states. The entropy density of extremal equilibrium states is also investigated in relation to macroscopic uniformity.Comment: 20 pages, revised in March 200

Off-Diagonal Long-Range Order: Meissner Effect and Flux Quantization

There has been a proof by Sewell that the hypothesis of off-diagonal long-range order in the reduced density matrix $\rho _2$ implies the Meissner effect. We present in this note an elementary and straightforward proof that not only the Meissner effect but also the property of magnetic flux quantization follows from the hypothesis. It is explicitly shown that the two phenomena are closely related, and phase coherence is the origin for both.Comment: 11 pages, Latex fil

Off-Diagonal Long-Range Order in Bose Liquids: Irrotational Flow and Quantization of Circulation

On the basis of gauge invariance, it is proven in an elementary and straightforward manner, but without invoking any {\it ad hoc} assumption, that the existence of off-diagonal long-range order in one-particle reduced density matrix in Bose liquids implies both the irrotational flow in a simply connected region and the quantization of circulation in a multiply connected region, the two fundamental properties of a Bose superfluid. The origin for both is the phase coherence of condensate wave-functions. Some relevant issues are also addressed.Comment: Revtex, 4 pages, no figure

On the Question of Temperature Transformations under Lorentz and Galilei Boosts

We provide a quantum statistical thermodynamical solution of the long standing problem of temperature transformations of uniformly moving bodies. Our treatment of this question is based on the well established quantum statistical result that the thermal equilibrium conditions demanded by both the Zeroth and Second Laws of Thermodynamics are precisely those of Kubo, Martin and Schwinger (KMS). We prove that, in both the special relativistic and nonrelativistic settings, a state of a body cannot satisfy these conditions for different inertial frames with non-zero relative velocity. Hence a body that serves as a thermal reservoir, in the sense of the Zeroth Law, in an inertial rest frame cannot do so in a laboratory frame relative to which it moves with non-zero uniform velocity. Consequently, there is no law of temperature transformation under either Lorentz or Galilei boosts, and so the concept of temperature stemming from the Zeroth Law is restricted to states of bodies in their rest frames.Comment: A few minor corrections have been made. The article will be published in J. Phys.

Growth, processing, and optical properties of epitaxial Er_2O_3 on silicon

Erbium-doped materials have been investigated for generating and amplifying light in low-power chip-scale optical networks on silicon, but several effects limit their performance in dense microphotonic applications. Stoichiometric ionic crystals are a potential alternative that achieve an Er^(3+) density 100× greater. We report the growth, processing, material characterization, and optical properties of single-crystal Er_2O_3 epitaxially grown on silicon. A peak Er^(3+) resonant absorption of 364 dB/cm at 1535nm with minimal background loss places a high limit on potential gain. Using high-quality microdisk resonators, we conduct thorough C/L-band radiative efficiency and lifetime measurements and observe strong upconverted luminescence near 550 and 670 nm

Numerically implemented perturbation method for the nonlinear magnetic moment of an anisotropic superconductor

We present a method to compute the magnetic moment of a bulk, finite-size, three-dimensional, anisotropic superconductor. Our numerically implemented perturbative procedure is based on a solution of the nonlinear Maxwell- London equations, where we include the nonlinear relation between current and gauge invariant velocity. The method exploits the small ratio of penetration depth to sample size. We show how to treat the open boundary conditions over an infinite domain and the continuity requirement at the interface. We demonstrate how our method substantially reduces the computational work required and discuss its implementation to an oblate spheroid. The numerical solution is obtained from a finite difference method. We briefly discuss the relevance of this work to similar problems in other fields.Comment: 43 pages RevTex ms and four postscript figures. To appear in Journal of Computational Physic

Intraocular solitary extramedullary plasmacytoma presenting as unilateral anterior and intermediate uveitis preceded by refractory glaucoma

Background: Solitary extramedullary plasmacytoma (SEP) is a localised proliferation of monoclonal plasma cells involving soft tissue with no or minimal bone marrow involvement and no other systemic evidence of multiple myeloma. Intraocular involvement is exceedingly rare. Case presentation: We report a 78-year-old man who was referred with glaucoma in the right eye. He subsequently developed anterior chamber (AC) inflammation and refractory glaucoma then dense vitritis. A vitrectomy was performed with the biopsy revealing numerous plasma cells with atypical findings. In conjunction with the flow cytometry results, and a systemic work up excluding multiple myeloma, a diagnosis of SEP was made. The patient was treated with ocular external beam radiotherapy with resolution of the intraocular inflammation and control of the intraocular pressure. He remains well with no local recurrence and no development of multiple myeloma over a follow up period of 2.5 years. Conclusions: This is the first case report of SEP presenting as intraocular inflammation without a uveal tract mass