Nutrigenomics analyze of expression of extracellular leptin receptor by the following essential oil monitoring at the avian models

Leptin gene was identified in 1994 by positional cloning. His mutation is considered extreme obesity surface phenotype and infertility in ob/ob mice. Most of the research, which followed the discovery of this hormone, focused on the role of leptin in regulating body weight,  in order to clarify the pathophysiology of obesity. Many research results show that leptin is not only important in regulating food intake and energy balance, but also performs functions such as metabolic and neuroendocrine hormone. Using herbs and essential oils depends on their antimicrobial activity. Most plants have favorable multifunctional properties, which are the specific content of bioactive components. Some authors characterize fytogénne substance such as natural substancese plant origin, which leave no residues in animal products and is not necessary to keep the trade period before slaughter animals. Analyses suggest that the structural function of the receptor exists as a dimer constructively in the plasma membrane. Each receptor dimer pair is reversibly bound to one molecule of leptin. When bound, signaling pathways are responsible for beginning the activation receptor associated Janus kinase 2 (JAK2) and tyrosine phosphorylation of two key residues in the intracellular part of receptor

Eo-Alpine metamorphism and the ‘mid-Miocene thermal event’ in the Western Carpathians (Slovakia): New evidence from multiple thermochronology

A combination of zircon (U–Th)/He (ZHe), apatite fission track (AFT) and apatite (U–Th)/He (AHe) dating methods is applied to constrain the metamorphic and exhumation history of the Tatric part of the Branisko Mountains in the Western Carpathians. ZHe ages from the basement samples prove the basement experienced a very low-grade to low-grade Eo-Alpine metamorphic overprint in mid-Cretaceous times. Miocene AFT and AHe ages found in the basement and in the Palaeogene sediments conclusively demonstrate that the Branisko Mts experienced a ‘mid-Miocene thermal event’. This thermal event had a regional character and was related to magmatic and/or burial heating that exposed the sediment and basement samples to ~ 120–130°C and ~ 100–190°C, respectively

Multiple low-temperature thermochronology constraints on exhumation of the Tatra Mountains: New implication for the complex evolution of the Western Carpathians in the Cenozoic

The tectonothermal evolution of the highest mountain range in the Carpathian arc—the Tatra Mountains— is investigated by zircon and apatite fission track and zircon (U-Th)/He (ZHe) dating methods in order to unravel the disputed exhumation and geodynamic processes in the Western Carpathians. Our data in combination with geological evidences reveal a complex Cenozoic history, with four major tectonothermal events: (i) a very low grade metamorphism of the crystalline basement at temperatures >240°C due to tectonic burial during the Eo-Alpine collision in the Late Cretaceous (~80 Ma); (ii) exhumation and cooling of the basement to temperatures 150°C after burial to 5–9 km depths by the Paleogene fore-arc basin; (iv) final exhumation of the segmented basement blocks during Oligocene-Miocene (32–11 Ma) owing to lateral extrusion of the North Pannonian plate and its collision with the European foreland. The spatial pattern of thermochronological data suggests asymmetric exhumation of the Tatra Mountains, beginning in the northwest at ~30–20 Ma with low cooling rates (~1–5°C/Ma) and propagating toward the major fault bounding the range in the south, where the youngest cooling ages (16–9 Ma) and fastest cooling rates (~10–20°C/Ma) are found. Our data prove that the Tatra Mountains shared Cenozoic evolution of other crystalline core mountains in the Western Carpathians. However, the Miocene ZHe ages suggest that the Tatra Mountains were buried to the greatest depths in the Paleogene-Early Miocene and experienced the greatest amount of Miocene exhumation

Carry trade

Publikace je určena na prvním místě těm politikům parlamentů všech zemí, kteří o fenoménu Carry trade zatím nic neví, a kteří jeho neovládáním nebo přehlížením a z toho plynoucí jimi nesprávně postavenou, zaměřenou, zákony schválenou, a poté i realizovanou státně-rozpočtovou politikou způsobují svým zemím významné a nevratné finanční ztráty. Dále je určena malým a středním podnikatelům, kterým pomůže prostřednictvím ziskového využití Carry trade zlepšit jejich pozici na trhu. Také je určena všem individuálním traderům a investorům na národních i světových finančních trzích, kteří o ní zatím nevědí – aby jejím využitím dosahovali v budoucnu zisky a nebyli (jak u nich bylo do doby její neznalosti) obvykle těmi, kteří se skládají na zisky znalců Carry trade. Nakonec je samozřejmě určena všem ekonomickým pedagogům – u těch by se měla stát jedním z jejich základních stavebních kamenů jejich ekonomických znalostí a dovedností.The publication is intended in the first place those politicians parliaments of all countries who have the phenomenon of carry trade yet knows nothing, and who because of their neglect and the resulting built them incorrectly, focused, laws approved, and then and the realized state-budget policy to their countries cause significant and irreversible financial losses. It is intended for small and medium-sized businesses, which will help carry through the profitable use of trade to improve their market position. It is also intended for all individual traders and investors in national and global financial markets, who know about it yet - to achieve its use in future profits and not (as they did until her ignorance) usually those who are made up of experts in profits Carry trade. Finally, of course, open to all economic teachers - those should become one of the basic building blocks of economic knowledge and skills.