Deep u*- and g-band Imaging of the Spitzer Space Telescope First Look Survey Field : Observations and Source Catalogs

We present deep u*-, and g-band images taken with the MegaCam on the 3.6 m Canada-France-Hawaii Telescope (CFHT) to support the extragalactic component of the Spitzer First Look Survey (hereafter, FLS). In this paper we outline the observations, present source catalogs and characterize the completeness, reliability, astrometric accuracy and number counts of this dataset. In the central 1 deg2 region of the FLS, we reach depths of g~26.5 mag, and u*~26.2 mag (AB magnitude, 5$\sigma$ detection over a 3" aperture) with ~4 hours of exposure time for each filter. For the entire FLS region (~5 deg2 coverage), we obtained u*-band images to the shallower depth of u*=25.0--25.4 mag (5$\sigma$, 3" aperture). The average seeing of the observations is 0.85" for the central field, and ~1.00" for the other fields. Astrometric calibration of the fields yields an absolute astrometric accuracy of 0.15" when matched with the SDSS point sources between 18<g<22. Source catalogs have been created using SExtractor. The catalogs are 50% complete and greater than 99.3% reliable down to g~26.5 mag and u*~26.2 mag for the central 1 deg2 field. In the shallower u*-band images, the catalogs are 50% complete and 98.2% reliable down to 24.8--25.4 mag. These images and source catalogs will serve as a useful resource for studying the galaxy evolution using the FLS data.Comment: 15 pages, 16 figure

Spitzer Mid-Infrared Spectroscopy of Infrared Luminous Galaxies at z~2 II: Diagnostics

We present mid-IR spectral decomposition of a sample of 48 Spitzer-selected ULIRGs spanning z~1-3 and likely L_IR~10^12-10^13Lsun. Our study aims at quantifying the star-formation and AGN processes in these sources which recent results suggest have evolved strongly between the observed epoch and today. To do this, we study the mid-IR contribution of PAH emission, continuum, and extinction. About 3/4 of our sample are continuum- (i.e. AGN) dominated sources, but ~60% of these show PAH emission, suggesting the presence of star-formation activity. These sources have redder mid-IR colors than typical optically-selected quasars. About 25% of our sample have strong PAH emission, but none are likely to be pure starbursts as reflected in their relatively high 5um hot dust continua. However, their steep 30um-to-14um slopes suggest that star-formation might dominate the total infrared luminosity. Six of our z~2 sources have EW6.2>~0.3um and L_14um>~10^12Lsun (implying L_IR>~10^13Lsun). At these luminosities, such high EW6.2 ULIRGs do not exist in the local Universe. We find a median optical depth at 9.7um of =1.4. This is consistent with local IRAS-selected ULIRGs, but differs from early results on SCUBA-selected z~2 ULIRGs. Similar to local ULIRGs about 25% of our sample show extreme obscuration (tau_9.7>~3) suggesting buried nuclei. In general, we find that our sources are similar to local ULIRGs, but are an order of magnitude more luminous. It is not clear whether our z~2 ULIRGs are simply scaled-up versions of local ULIRGs, or subject to fundamentally different physical processes.Comment: 60 pages, 15 figures, accepted for publication in Ap

Decreased O2 consumption by PMNL from humans and rats with CRF: Role of secondary hyperparathyroidism

Decreased O2 consumption by PMNL from humans and rats with CRF: Role of secondary hyperparathyroidism. Bactericidal ability of polymorphonuclear leukocytes (PMNL) is impaired in chronic renal failure (CRF). This function of PMNL is mediated by the generation of oxidizing radicals and the latter event requires O2 consumption by these cells. The present study examined both basal and FMLP-stimulated rise in cytosolic calcium ([Ca2+]i) and O2 consumption of PMNL from normal subjects and hemodialysis patients and from CRF rats, and evaluated the potential role of secondary hyperparathyroidism of CRF on these properties of PMNL. Basal levels of [Ca2+]i were significantly higher, and FMLP-induced increments in [Ca2+]i were significantly lower in PMNL of both humans and rats with CRF than in normals. Basal and FMLP-stimulated O2 consumption were significantly lower in CRF subjects and rats than in normals. These derangements were prevented by prior parathyroidectomy of CRF rats or by their treatment with verapamil from day one of CRF. Also, therapy of rats with pre-existing CRF with this drug reversed the abnormalities in [Ca2+]i and in O2 consumption of PMNL. The data indicate that: (1) CRF is associated with derangements in the homeostasis of [Ca2+]i of PMNL and their oxygen consumption, (2) these abnormalities are, most likely, mediated by the state of secondary hyperparathyroidism of CRF, and (3) verapamil, which blocks the PTH-induced entry of calcium into cells, and prevents as well as reverses these PMNL dysfunctions. These results implicate the excess PTH of CRF in the genesis of the defective bactericidal function of PMNL, and assign a new dimension to PTH toxicity in CRF

Insulin release from pancreatic islets: Effects of CRF and excess PTH

Insulin release from pancreatic islets: Effects of CRF and excess PTH. Insulin secretion may be impaired in chronic renal failure (CRF) and available data suggest that this abnormality may be related to the state of secondary hyperparathyroidism of renal failure. We directly measured insulin release from isolated islets of Langerhans obtained from normal rats, CRF-control and CRF-PTX (parathyroidectomized) rats, and parathyroid hormone (PTH)-treated animals. Both early and total glucose-induced insulin release from islets of CRF-control were markedly and significantly (P < 0.01) lower than from islets of normal rats. Insulin release from islets of CRF-PTX rats was significantly (P < 0.01) higher than that from islets of CRF-control rats, and not different from insulin release from islets of normal rats. Forskolin and IBMX, which cause a rise in cAMP, significantly stimulated glucose-induced insulin release from islets of normal, CRF-control and CRF-PTX rats, but the increments from baseline were not significantly different between the three groups. Both early and total insulin release from islets obtained from PTH-treated rats with normal renal function were markedly and significantly (P < 0.01) lower than values obtained from normal rats. Calcium contents of the pancreas of CRF-control and PTH-treated rats were significantly (P < 0.01) higher than that in pancreas of normal rats and CRF-PTX animals, and values in the latter two groups of animals were not significantly different. The results show that: 1) CRF impairs insulin release from pancreatic islets; 2) this abnormality is reversed by prior parathyroidectomy; and 3) hyperparathyroidism induced by PTH-treatment in normal rats impairs insulin release from pancreatic islets. The data provide a direct evidence for the role of secondary hyperparathyroidism in the genesis of abnormal carbohydrate metabolism in CRF. This effect of excess PTH is not related to alterations in cAMP production but may potentially be due to calcium accumulation in the pancreas

Infrared luminosities and aromatic features in the 24 μm flux-limited sample of 5muses

We study a 24 μm selected sample of 330 galaxies observed with the infrared spectrograph for the 5 mJy Unbiased Spitzer Extragalactic Survey. We estimate accurate total infrared luminosities by combining mid-IR spectroscopy and mid-to-far infrared photometry, and by utilizing newempirical spectral templates from Spitzer data. The infrared luminosities of this sample range mostly from 10^9 L_⊙ to 10^(13.5) L_⊙,with 83% in the range 10^(10) L_⊙ < L_(IR) < 10^(12) L_⊙. The redshifts range from 0.008 to 4.27, with a median of 0.144. The equivalent widths of the 6.2 μm aromatic feature have a bimodal distribution, probably related to selection effects. We use the 6.2μm polycyclic aromatic hydrocarbon equivalent width (PAH EW) to classify our objects as starburst (SB)-dominated (44%), SB-AGN composite (22%), and active galactic nucleus (AGN)-dominated (34%). The high EW objects (SB-dominated) tend to have steeper mid-IR to far-IR spectral slopes and lower L_(IR) and redshifts. The low EW objects (AGN-dominated) tend to have less steep spectral slopes and higher L_(IR) and redshifts. This dichotomy leads to a gross correlation between EW and slope, which does not hold within either group. AGN-dominated sources tend to have lower log(L_(PAH7.7 μm)/L_(PAH11.3 μm)) ratios than star-forming galaxies, possibly due to preferential destruction of the smaller aromatics by the AGN. The log(L_(PAH7.7 μm)/L_(PAH11.3 μm)) ratios for star-forming galaxies are lower in our sample than the ratios measured from the nuclear spectra of nearby normal galaxies, most probably indicating a difference in the ionization state or grain size distribution between the nuclear regions and the entire galaxy. Finally, we provide a calibration relating the monochromatic continuum or aromatic feature luminosity to L_(IR) for different types of objects

Impaired insulin secretion of aging: Role of renal failure and hyperparathyroidism

Impaired insulin secretion of aging: Role of renal failure and hyperparathyroidism. Available data indicate that insulin secretion is impaired with aging. Almost all the studies that examined insulin secretion by old animals did not take into consideration the state of renal function or the blood levels of parathyroid hormone (PTH). Old animals may have chronic renal failure (CRF) and secondary hyperparathyroidism, and both of these conditions impair insulin secretion. It is possible, therefore, that the impaired insulin secretion of aging is not due to old age per se, but rather to associated CRF and excess PTH. The present study examined this issue in adult (6 month old) and senescent rats (2 years old) with and without CRF and excess PTH. Senescent rats without CRF had normal renal function and normal blood levels of PTH, and the values were not different from those observed in adult rats. Creatinine clearance in senescent rats with CRF was significantly (P < 0.01) lower and serum levels of PTH were significantly (P < 0.01) higher than in senescent animals without CRF and than in the adult rats as well. Only the senescent rats with CRF displayed glucose intolerance during intravenous glucose tolerance test. For any given level of blood glucose, plasma insulin levels were lower in senescent rats with CRF than in the adult rat or senescent animals without CRF. Both initial phase (139 ± 45 pg/islet · 8 min) and total (808 ± 216 pg/islet · 33 min) insulin secretion from pancreatic islets of the senescent rats with CRF and excess PTH were significantly lower than those in senescent rats with normal renal function (658 ± 117 pg/islet · 8 min and 3294 ± 290 pg/islet · 33 min, respectively) or in adult rats (710 ± 134 pg/islet · 8 min and 3183 ± 366 pg/islet · 33 min, respectively). There were no significant differences in insulin secretion between the adult rats and the senescent ones with normal renal function. The data demonstrate that the impaired insulin secretion by the pancreatic islets in old rats is not necessarily related to the higher age per se, but is due to the associated CRF and secondary hyperparathyroidism that develops in many, but not all old animals. Our results indicate that studies examining the effect of aging on body function should take into consideration the level of renal function and of the serum PTH, since both CRF and excess PTH adversely affect the functional integrity of many organs

Spitzer Mid-Infrared Spectroscopy of Infrared Luminous Galaxies at z ~ 2. I. The Spectra

We present the mid-infrared spectra obtained with the Spitzer IRS for 52 sources, selected as infrared luminous, z ≳ 1 candidates in the Extragalactic First Look Survey. The sample selection criteria are f_(24 μm) ≳ 0.9 mJy, νf_ν(24 μm)/νf_ν(8 μm) ≳ 3.16, and νf_ν(24 μm)/νf_ν(0.7 μm) ≳ 10. Of the 52 spectra, 47 (90%) produced measurable redshifts based solely on the mid-IR spectral features, with 35/47 (74%) at 1.5 ≲ z ≲ 3.2. Keck spectroscopy of a subsample (17/47) agrees with the mid-IR redshift measurements. The observed spectra fall into three categories: (1) 33% (17/52) have strong PAH emission and are probably powered by star formation with total IR luminosity roughly a factor of 5 higher than the local starburst ULIRGs; (2) 33% (17/52) have only deep silicate absorption at 9.8 μm, indicatiing deeply embedded dusty systems—these data alone cannot determine the energetic nature of the heating sources in these systems; and (3) the remaining 34% are mid-IR continuum-dominated systems with weak PAH emission and/or silicate absorption. This subsample is probably AGNs. We derived monochromatic, rest-frame 5.8 μm, continuum luminosities (νL_ν), ranging from 10^(10.3) to 10^(12.6) L_☉. Our spectra have mid-IR slope α_(5-15 μm) ≳ 2.1, much redder than the median value of 1.3 for the optically selected PG quasars. From the silicate absorption feature, we estimate that roughly two-thirds of the sample have optical depth τ_(9.8 μm) > 1. Their L_(1600 Å) and L_(IR) suggest that our sample is among the most luminous and most dust-enshrouded systems of its epoch. Our study has revealed a significant population of dust-enshrouded galaxies at z ~ 2, whose enormous energy output, comparable to that of quasars, is generated by AGNs, as well as starbursts. This IR-luminous population has very little overlap with submillimeter and UV-selected populations

The ~0.9 mJy sample: A mid-infrared spectroscopic catalog of 150 infrared-luminous, 24 micron selected galaxies at 0.3<z<3.5

We present a catalog of mid-infrared (MIR) spectra of 150 infrared (IR) luminous galaxies in the Spitzer extragalactic first look survey obtained with IRS on board Spitzer. The sample is selected to be brighter than ~0.9 mJy at 24 micron and it has a z distribution in the range [0.3,3.5] with a peak at z=1. It primarily comprises ultraluminous IR galaxies at z>1 and luminous IR galaxies at z<1, as estimated from their monochromatic 14 micron luminosities. The number of sources with spectra that are dominated by an active galactic nucleus (AGN) continuum is 49, while 39 sources have strong, star-formation related features. For this classification, we used the equivalent width (EW) of the 11.3 micron polycyclic aromatic hydrocarbon (PAH) feature. Several intermediate/high z starbursts have higher PAH EW than local ULIRGs. An increase in the AGN activity is observed with increasing z and luminosity, based on the decreasing EW of PAHs and the increasing [NeIII]/[NeII] ratio. Spectral stacking leads to the detection of the 3.3 micron PAH, the H2 0-0 S(1) and S(3) lines, and the [NeV] line. We observe differences in the flux ratios of PAHs in the stacked spectra of IR-luminous galaxies with z or luminosity, which are not due to extinction effects. When placing the observed galaxies on IR color-color diagrams, we find that the wedge defining AGN comprises most sources with continuum-dominated spectra, but also contains many starbursts. The comparison of the 11.3 micron PAH EW and the H-band effective radius, measured from HST data, indicates that sources with EW>2 micron, are typically more extended than ~3 kpc. However, there is no strong correlation between the MIR spectral type and the near-IR extent of the sources. [Abridged].Comment: accepted for publication in the Astrophysical Journa