Stille Post oder Wie Goethe vor dem Ersaufen gerettet wurde : deutsche, russische und englische "Grenzen der Menschheit"

"During a Thunder-Storm", ein 1821 veröffentlichtes Gedicht über das Verhältnis des Menschen zu Gott von John Bowring (1792-1872), hat unlängst einige Aufmerksamkeit auf sich gezogen. Es bildete den obligatorischen Aufgabenteil des Übersetzungswettbewerbes Lyrik-Shuttle, der anläßlich des Europäischen Jahrs der Sprachen 2001 gemeinsam vom Lyrik-Kabinett München und dem Münchener Institut für Allgemeine und Vergleichende Literaturwissenschaft (Komparatistik) erstmalig veranstaltet wurde. Neben der Gebundenheit durch Metrum und Reim, dem Alter und der anspruchsvollen Wortwahl bestand einer der Auswahlgründe für dieses Gedicht seitens der Organisatoren darin, daß es sich um einen unbekannten Text handelte. Die TeilnehmerInnen des Wettbewerbs sollten bei ihrer Lösung der Übersetzungsaufgabe alternativlos Neuland betreten und nicht – wie bei einem prominenteren Gedicht (bzw. Verfasser) zu erwarten – durch bereits vorliegende Nachdichtungen beeinflußt werden. Vor einhundertsiebzig, ja wohl auch noch vor einhundertfünfzig Jahren konnte "During a Thunder-Storm" dagegen eine weit größere Popularität für sich beanspruchen. Die Geschichte, die damit verbunden ist, liefert ein aufschlußreiches Fallbeispiel aus dem Bereich der internationalen literarischen Kommunikation – der zeitgenössischen Entwicklung, die für den späten Goethe zunehmend ins Zentrum seines Interesses rückte und die er seit dem Ende der 1820er Jahre unter der Losung "Weltliteratur" offensiv propagierte

Arbeitspensum eines Achtundsiebzigjährigen : eine unbekannte Agenda Goethes vom November und Dezember 1827

Das Anlegen von Agenden gehört zu den grundlegenden Elementen der Arbeits- und Lebensorganisation Goethes. [...] Zwar wird diesen Arbeitslisten dort erst ab dem Jahr 1802 eine eigene (Teil)Rubrik zugestanden, doch findet sich bereits unter dem 1. Januar 1782 der Tagebucheintrag: "Früh verschiednes in Ordnung. Agenda durchgesehn und überlegt." [...] Im Januar 1790 nahm sich Goethe unter anderem die Fertigstellung der Bearbeitungen von Torquato Tasso, Lila, Jery und Bätely sowie Faust für die Schriften vor; daneben finden sich auf der Agenda aber auch Einträge, wie "Bergwerck", "Schloß Bau" oder "Erotica". [...] Auf Anfang 1799 schließlich datiert eine Arbeitsliste Goethes, die mit dem Nebeneinander von Orts- und Personennamen, Titeln literarischer und naturwissenschaftlicher Werke, Sachbegriffen usw. bereits ein typisches Merkmal der späteren, bis zum März 1832 reichenden Agenden aufweist: "Agenda in Jena | vom 7. Jan. an. | Hiller. | Merseburg. | Farbenlehre | Propylaeen. 2. B. 1 Stück. | Faust. | Mahomet | Uber Piccolomini. | Sammler. | Bibliotheck | Tyger.

The impact of direct oral anticoagulants on viscoelastic testing – A systematic review

Background: In case of bleeding patients and in acute care, the assessment of residual direct oral anticoagulant (DOAC) activity is essential for evaluating the potential impact on hemostasis, especially when a timely decision on urgent surgery or intervention is required. Viscoelastic tests are crucial in a modern goal-directed coagulation management to assess patients' coagulation status. However, the role of viscoelastic test to detect and quantify residual DOAC plasma levels is controversially discussed. The aim of this review was to systematically summarize the evidence of viscoelastic tests for the assessment of residual DOAC activity. Method: PubMed, Embase, Scopus, and the Cochrane Library were searched for original articles investigating the effect of rivaroxaban, apixaban, edoxaban, or dabigatran plasma levels on different viscoelastic tests of the adult population from database inception to December 31, 2021. Results: We included 53 studies from which 31 assessed rivaroxaban, 22 apixaban, six edoxaban, and 29 dabigatran. The performance of viscoelastic tests varied across DOACs and assays. DOAC specific assays are more sensitive than unspecific assays. The plasma concentration of rivaroxaban and dabigatran correlates strongly with the ROTEM EXTEM, ClotPro RVV-test or ECA-test clotting time (CT) and TEG 6s anti-factor Xa (AFXa) or direct thrombin inhibitor (DTI) channel reaction time (R). Results of clotting time (CT) and reaction time (R) within the normal range do not reliable exclude relevant residual DOAC plasma levels limiting the clinical utility of viscoelastic assays in this context. Conclusion: Viscoelastic test assays can provide fast and essential point-of-care information regarding DOAC activity, especially DOAC specific assays. The identification and quantification of residual DOAC plasma concentration with DOAC unspecific viscoelastic assays are not sensitive enough, compared to recommended anti-Xa activity laboratory measurements. Systematic review registration: [https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=320629], identifier [CRD42022320629]. Keywords: ClotPro; DOAC; FII inhibitor; FXa inhibitor; ROTEM; TEG; point-of-car

Assessing the Feasibility and Acceptability of a Primary Care Socio-Ecological Approach to Improve Physical Activity Adherence among People with Type 2 Diabetes : The SENWI Project

Ajuts: This research was funded by Col·legi de Fisioterapeutes de Catalunya (CFC), grant number R05/21.Maintaining an active lifestyle is a key health behavior in people with type 2 diabetes (T2D). This study assessed the feasibility and acceptability of a socio-ecological Nordic walking intervention (SENWI) to enhance healthy behaviors in primary healthcare settings. Participants included individuals with T2D (n = 33; age 70 (95% CI 69-74)) and healthcare professionals (HCPs, n = 3). T2D participants were randomly assigned to a SENWI, active comparator, or control group for twelve weeks. Feasibility and acceptability were evaluated based on a mixed methodology. Quantitative data reported adherence information, differences between follow-up and dropout participants and pre- and post-intervention on physical activity, sedentary behavior, and health outcomes. Qualitative data acquisition was performed using focus groups and semi-structured interviews and analyzed using thematic analysis. Thirty-three T2D invited participants were recruited, and twenty-two (66.7%) provided post-intervention data. The SENWI was deemed acceptable and feasible, but participants highlighted the need to improve options, group schedules, gender inequities, and the intervention's expiration date. Healthcare professionals expressed a lack of institutional support and resources. Nevertheless, no significant difference between the SENWI follow-up and dropout participants or pre- and post- intervention was found (only between the active comparator and control group in the physical quality of life domain). Implementing the SENWI in primary healthcare settings is feasible and acceptable in real-world conditions. However, a larger sample is needed to assess the program's effectiveness in improving healthy behaviors and its impact on health-related outcomes in the long term

Predictors associated with mortality of extracorporeal life support therapy for acute heart failure: single-center experience with 679 patients

Background: Extracorporeal life support (ECLS) therapy is increasingly used for cardiac and respiratory support postcardiotomy, refractory cardiogenic shock and cardiopulmonary resuscitation. This study aims to describe in-hospital mortality of patients requiring ECLS, identify independent predictors associated with mortality and analyze changes of mortality over time. Methods: This retrospective study includes all adult ECLS cases at the University Hospital Zurich, a designated ECLS center in Switzerland, in the period 2007 to 2019. Results: ECLS therapy was required in 679 patients (median age 60 years, 27.5% female). In-hospital mortality was 55.5%. Cubic spline interpolation did not detect evidence for a change in mortality over the whole period of 13 years. In-hospital mortality significantly varied between ECLS indications: 70.7% (152/215) for postcardiotomy, 67.9% (108/159) for cardiopulmonary resuscitation, 47.0% (110/234) for refractory cardiogenic shock, and 9.9% (7/71) for lung transplantation and expansive thoracic surgery (P<0.001). Logistic regression modelling showed excellent discrimination in the receiver operating characteristic (ROC) area under the curve (AUC) of 0.89 [95% confidence interval (CI): 0.87-0.92] and identified significant mortality predictors: age, simplified acute physiology score (SAPS) II, as well as new liver failure and each allogenic blood transfusion unit given per day. ECLS after cardiopulmonary resuscitation was associated with significantly higher mortality compared to ECLS for refractory cardiogenic shock. Conclusions: In-hospital mortality of patients treated with ECLS therapy is high. Outcomes have not changed significantly in the observed period. We identified age, SAPS II, new liver failure and each allogenic blood transfusion unit given per day as independent mortality predictors. Knowledge of predictors strongly associated with in-hospital mortality may affect future decisions about ECLS indications and the respective management to use this elaborate therapy more effectively. Keywords: Extracorporeal circulation; extracorporeal life support (ECLS)/extracorporeal membrane oxygenation (ECMO); mortality; outcome; predictor

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences

The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on 18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based researchers who signed it in the short time span from 20 September to 6 October 2016