U-duality from Matrix Membrane Partition Function

We analyse supermembrane instantons (fully wrapped supermembranes) by computing the partition function of the three-dimensional supersymmetrical U(N) matrix model under periodic boundary conditions. By mapping the model to a cohomological field theory and considering a mass-deformation of the model, we show that the partition function exactly leads to the U-duality invariant measure factor entering supermembrane instanton sums. On the other hand, a computation based on the quasi-classical assumption gives the non U-duality invariant result of the zero-mode analysis by Pioline et al. This is suggestive of the importance of supermembrane self-interactions and shows a crucial difference from the matrix string case.Comment: harvmac, 16 pages. v2: minor textual changes. version to appear in Physics Letter

The Hypermultiplet with Heisenberg Isometry in N=2 Global and Local Supersymmetry

The string coupling of N=2 supersymmetric compactifications of type II string theory on a Calabi-Yau manifold belongs to the so-called universal dilaton hypermultiplet, that has four real scalars living on a quaternion-Kaehler manifold. Requiring Heisenberg symmetry, which is a maximal subgroup of perturbative isometries, reduces the possible manifolds to a one-parameter family that describes the tree-level effective action deformed by the only possible perturbative correction arising at one-loop level. A similar argument can be made at the level of global supersymmetry where the scalar manifold is hyper-Kaehler. In this work, the connection between global and local supersymmetry is explicitly constructed, providing a non-trivial gravity decoupled limit of type II strings already in perturbation theory.Comment: 24 page

The battle for chitin recognition in plant-microbe interactions

Fungal cell walls play dynamic functions in interaction of fungi with their surroundings. In pathogenic fungi, the cell wall is the first structure to make physical contact with host cells. An important structural component of fungal cell walls is chitin, a well-known elicitor of immune responses in plants. Research into chitin perception has sparked since the chitin receptor from rice was cloned nearly a decade ago. Considering the widespread nature of chitin perception in plants, pathogens evidently evolved strategies to overcome detection, including alterations in the composition of cell walls, modification of their carbohydrate chains and secretion of effectors to provide cell wall protection or target host immune responses. Also non-pathogenic fungi contain chitin in their cell walls and are recipients of immune responses. Intriguingly, various mutualists employ chitin-derived signaling molecules to prepare their hosts for the mutualistic relationship. Research on the various types of interactions has revealed different molecular components that play crucial roles and, moreover, that various chitin-binding proteins contain dissimilar chitin-binding domains across species that differ in affinity and specificity. Considering the various strategies from microbes and hosts focused on chitin recognition, it is evident that this carbohydrate plays a central role in plant-fungus interaction

U(1) x U(1) Quaternionic Metrics from Harmonic Superspace

We construct, using harmonic superspace and the quaternionic quotient approach, a quaternionic-K\"ahler extension of the most general two centres hyper-K\"ahler metric. It possesses $U(1)\times U(1)$ isometry, contains as special cases the quaternionic-K\"ahler extensions of the Taub-NUT and Eguchi-Hanson metrics and exhibits an extra one-parameter freedom which disappears in the hyper-K\"ahler limit. Some emphasis is put on the relation between this class of quaternionic-K\"ahler metrics and self-dual Weyl solutions of the coupled Einstein-Maxwell equations. The relation between our explicit results and the recent general ansatz of Calderbank and Pedersen for quaternionic-K\"ahler metrics with $U(1)\times U(1)$ isometries is traced in detail.Comment: 40 pages,0 figure Minor corrected typo

Source localization using Poisson integrals

International audienceThis paper deals with the problem of source localization in diffusion processes via several sensor devices providing pointwise concentration measures; sensors are assumed to be arranged in circular arrays, they can be fixed along the array or they can turn along a circular path defined by the array. The originality of the proposed source localization solution lies in the computation of the gradient and of higher-order derivatives (i. e., the Hessian) from Poisson integrals; in opposition to other solutions published in the literature, this computation does neither require specific knowledge of the solution of the difiusion process, nor the use of probing signals, but only exploits properties of the PDE. The Laplacian of the measured value is null on the studied domain; such an assumption is justified for isotropic diffusive sources in steady-state. The paper also presents some simulation results of a source-seeking torque control law for mobile non-holonomic robots looking for a heat source in a room, where the source is modeled as a small circular region

Quaternionic Extension of the Double Taub-NUT Metric

Starting from the generic harmonic superspace action of the quaternion-K\"ahler sigma models and using the quotient approach we present, in an explicit form, a quaternion-K\"ahler extension of the double Taub-NUT metric. It possesses $U(1)\times U(1)$ isometry and supplies a new example of non-homogeneous Einstein metric with self-dual Weyl tensor.Comment: 12 pages, 0 figure, latex file, to appear in Phys. Lett.B, reference corrected, Dubna preprint number adde

Automated alignment-based curation of gene models in filamentous fungi

BACKGROUND: Automated gene-calling is still an error-prone process, particularly for the highly plastic genomes of fungal species. Improvement through quality control and manual curation of gene models is a time-consuming process that requires skilled biologists and is only marginally performed. The wealth of available fungal genomes has not yet been exploited by an automated method that applies quality control of gene models in order to obtain more accurate genome annotations. RESULTS: We provide a novel method named alignment-based fungal gene prediction (ABFGP) that is particularly suitable for plastic genomes like those of fungi. It can assess gene models on a gene-by-gene basis making use of informant gene loci. Its performance was benchmarked on 6,965 gene models confirmed by full-length unigenes from ten different fungi. 79.4% of all gene models were correctly predicted by ABFGP. It improves the output of ab initio gene prediction software due to a higher sensitivity and precision for all gene model components. Applicability of the method was shown by revisiting the annotations of six different fungi, using gene loci from up to 29 fungal genomes as informants. Between 7,231 and 8,337 genes were assessed by ABFGP and for each genome between 1,724 and 3,505 gene model revisions were proposed. The reliability of the proposed gene models is assessed by an a posteriori introspection procedure of each intron and exon in the multiple gene model alignment. The total number and type of proposed gene model revisions in the six fungal genomes is correlated to the quality of the genome assembly, and to sequencing strategies used in the sequencing centre, highlighting different types of errors in different annotation pipelines. The ABFGP method is particularly successful in discovering sequence errors and/or disruptive mutations causing truncated and erroneous gene models. CONCLUSIONS: The ABFGP method is an accurate and fully automated quality control method for fungal gene catalogues that can be easily implemented into existing annotation pipelines. With the exponential release of new genomes, the ABFGP method will help decreasing the number of gene models that require additional manual curation

“CATAStrophy,” a Genome-Informed Trophic Classification of Filamentous Plant Pathogens – How Many Different Types of Filamentous Plant Pathogens Are There?

The traditional classification of fungal and oomycete phytopathogens into three classes – biotrophs, hemibiotrophs, or necrotrophs – is unsustainable. This study highlights multiple phytopathogen species for which these labels have been inappropriately applied. We propose a novel and reproducible classification based solely on genome-derived analysis of carbohydrate-active enzyme (CAZyme) gene content called CAZyme-Assisted Training And Sorting of -trophy (CATAStrophy). CATAStrophy defines four major divisions for species associated with living plants. These are monomertrophs (Mo) (corresponding to biotrophs), polymertrophs (P) (corresponding to necrotrophs), mesotrophs (Me) (corresponding to hemibiotrophs), and vasculartrophs (including species commonly described as wilts, rots, or anthracnoses). The Mo class encompasses symbiont, haustorial, and non-haustorial species. Me are divided into the subclasses intracellular and extracellular Me, and the P into broad and narrow host sub-classes. This gives a total of seven discrete plant-pathogenic classes. The classification provides insight into the properties of these species and offers a facile route to develop control measures for newly recognized diseases. Software for CATAStrophy is available online at https://github.com/ccdmb/catastrophy. We present the CATAStrophy method for the prediction of trophic phenotypes based on CAZyme gene content, as a complementary method to the traditional tripartite “biotroph–hemibiotroph–necrotroph” classifications that may encourage renewed investigation and revision within the fungal biology community.</p