Right-Angle Shaped Elements as Dual-Band Metamaterial Absorber in Terahertz

AbstractMetamaterial absorbers display potential applications in the field of photonics and have been investigated extensively during the last decade. We propose a dual-band resonant metamaterial absorber with right-angle shaped elements (RAEs) in the terahertz range based on numerical simulations. The absorber remains insensitive to a wide range of incidence angles (0°–70°) by showing a minimum absorbance of ~80% at 70°. Furthermore, the proposed absorber is highly independent on any state of polarization of the incidence electromagnetic wave due to the high absorbance, i.e., greater than 80%, recorded for the considered polarization states. To further comprehend the slight variations in absorbance as a function of change in the angle of incidence, the impedance of the structure has been critically examined. The metamaterial absorber is simple in design, and we provide a possible path of fabrication.</jats:p

Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography

Novel excipients are entering the market to enhance the bioavailability of drug particles by having a high porosity and, thus, providing a rapid liquid uptake and disintegration to accelerate subsequent drug dissolution. One example of such a novel excipient is functionalized calcium carbonate, which enables the manufacture of compacts with a bimodal pore size distribution consisting of larger interparticle and fine intraparticle pores. Five sets of functionalized calcium carbonate tablets with a target porosity of 45%-65% were prepared in 5% steps and characterized using terahertz time-domain spectroscopy and X-ray computed microtomography. Terahertz time-domain spectroscopy was used to derive the porosity using effective medium approximations, that is, the traditional and an anisotropic Bruggeman model. The anisotropic Bruggeman model yields the better correlation with the nominal porosity (R$^{2}$ = 0.995) and it provided additional information about the shape and orientation of the pores within the powder compact. The spheroidal (ellipsoids of revolution) shaped pores have a preferred orientation perpendicular to the compaction direction causing an anisotropic behavior of the dielectric porous medium. The results from X-ray computed microtomography confirmed the nonspherical shape and the orientation of the pores, and it further revealed that the anisotropic behavior is mainly caused by the interparticle pores. The information from both techniques provides a detailed insight into the pore structure of pharmaceutical tablets. This is of great interest to study the impact of tablet microstructure on the disintegration and dissolution performance.Drs Markl and Zeitler would like to acknowledge the U.K. Engineering and Physical Sciences Research Council for funding (EP/L019922/1)

Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging

Cost effectiveness, ease of use and patient compliance make pharmaceutical tablets the most popular and widespread form to administer a drug to a patient. Tablets typically consist of an active pharmaceutical ingredient and a selection from various excipients. A novel highly porous excipient, functionalised calcium carbonate (FCC), was designed to facilitate rapid liquid uptake leading to disintegration times of FCC based tablets in the matter of seconds. Five sets of FCC tablets with a target porosity of 45% to 65% in 5% steps were prepared and characterised using terahertz pulsed imaging (TPI). The high acquisition rate (15 Hz) of TPI enabled the analysis of the rapid liquid imbibition of water into these powder compacts. The penetration depth determined from the TPI measurements as a function of time was analysed by the power law and modelled by the Lucas-Washburn (LW) equation. The analysis of the hydraulic radius estimated by fitting the liquid imbibition data to the LW equation demonstrates the impact of the porosity as well as the tortuosity of the pore channels on the liquid uptake performance. The tortuosity was related to the porosity by a geometrical model, which shows that the powder compact is constructed by aggregated particles with low permeability and its principal axis perpendicular to the compaction direction. The consideration of the tortuosity yielded a very high correlation (R2 = 0.96) between the porosity and the hydraulic pore radius. The terahertz data also resolved fluctuations (0.9 to 1.3 Hz) of the liquid movement which become more pronounced and higher in frequency with increasing porosity, which is attributed to the constrictivity of pore channels. This study highlights the strong impact of a tablet's microstructure on its liquid penetration kinetics and thus on its disintegration behaviour

Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging

Cost effectiveness, ease of use and patient compliance make pharmaceutical tablets the most popular and widespread form to administer a drug to a patient. Tablets typically consist of an active pharmaceutical ingredient and a selection from various excipients. A novel highly porous excipient, functionalised calcium carbonate (FCC), was designed to facilitate rapid liquid uptake leading to disintegration times of FCC based tablets in the matter of seconds. Five sets of FCC tablets with a target porosity of 45% to 65% in 5% steps were prepared and characterised using terahertz pulsed imaging (TPI). The high acquisition rate (15 Hz) of TPI enabled the analysis of the rapid liquid imbibition of water into these powder compacts. The penetration depth determined from the TPI measurements as a function of time was analysed by the power law and modelled by the Lucas-Washburn (LW) equation. The analysis of the hydraulic radius estimated by fitting the liquid imbibition data to the LW equation demonstrates the impact of the porosity as well as the tortuosity of the pore channels on the liquid uptake performance. The tortuosity was related to the porosity by a geometrical model, which shows that the powder compact is constructed by aggregated particles with low permeability and its principal axis perpendicular to the compaction direction. The consideration of the tortuosity yielded a very high correlation (R2 = 0.96) between the porosity and the hydraulic pore radius. The terahertz data also resolved fluctuations (0.9 to 1.3 Hz) of the liquid movement which become more pronounced and higher in frequency with increasing porosity, which is attributed to the constrictivity of pore channels. This study highlights the strong impact of a tablet's microstructure on its liquid penetration kinetics and thus on its disintegration behaviour

Difficulties of Subsurface Liquid Front Tracking in Porous Media with Terahertz Pulsed Imaging

Terahertz pulsed imaging (TPI) coupled with a customised flow cell has previously been used successfully to study liquid transport in porous media, such as powder compacts. In some samples, the tracking of the liquid front remains challenging when the refractive indices of liquid and sample are similar and hence little contrast is observed. In this work, we found that even when the relative difference between the refractive indices of liquid and sample is high, it can still be challenging to track the reflection peak of water in some samples while it works fine in others. It is hypothesised that this is due to the formation of a water gradient in these samples due to their specific microstructure and we explore methods to overcome this limitation

Data for Simultaneous investigation of the liquid transport and swelling performance during tablet disintegration

Raw data. The files contained in this folder are .mat files for the terahertz data and .csv files for the mercury porosimetry data. The subfolders are: Mercury porosimetry data; Terahertz time-domain spectroscopy data in the folder (THz-TDS); Terahertz pulsed imaging data in the folder (TPI). See the readme.txt file for detailed information about this dataset