Academic institutional repositories in China: A survey of CALIS member libraries

Purpose: China Academic Library &amp; Information System (CALIS) planned to launch an institutional repository (IR) project to promote IR development and open access at colleges and universities in China. In order to get to know the current state of IRs in academic institutions, with the help of Peking University Library, CALIS Administrative Center conducted this survey.Design/methodology/approach: We conducted an online survey of CALIS member libraries.Findings: Firstly, the development of IRs at China's colleges and universities is still in its infancy. Secondly, the Chinese colleges and universities have reached a consensus on the objective for having an IR. Thirdly, they are having high expectations of IR&nbsp;functions. Fourthly, they prefer to establish a centralized IR system at a minimum cost. Finally, there are both similarities and differences between the Chinese academic institutions and their counterparts in other countries in the state of IR development.Research limitations: The questionnaire needs to be improved because there is a lack of enough questions for those who do not plan to build an IR. Comparatively lower rate of valid questionnaire return can affect the accuracy of the results. It is hard to go into an in-depth discussion only based on the data collected from this questionnaire survey, and consequently, the findings from the survey can hardly present an accurate and comprehensive picture of the current state of IR development in the academic sector in China.Practical implications: The survey results provide essential foundation for CALIS IR project, and meanwhile the research can serve as a reference source for the future studies of the development of IRs at China's colleges and universities.Originality/value: It is the first national survey focused on the development of IRs in academic institutions in China.</p

HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine.

Small-molecule inhibitors for the 90-kDa heat shock protein (HSP90) have been extensively exploited in preclinical studies for the therapeutic interventions of human diseases accompanied with proteotoxic stress. By using an unbiased quantitative proteomic method, we uncover that treatment with three HSP90 inhibitors results in elevated expression of a large number of heat shock proteins. We also demonstrate that the HSP90 inhibitor-mediated increase in expression of DNAJB4 protein occurs partly through an epitranscriptomic mechanism, and is substantially modulated by the writer, eraser, and reader proteins of N6-methyladenosine (m6A). Furthermore, exposure to ganetespib leads to elevated modification levels at m6A motif sites in the 5'-UTR of DNAJB4 mRNA, and the methylation at adenosine 114 site in the 5'-UTR promotes the translation of the reporter gene mRNA. This m6A-mediated mechanism is also at play upon heat shock treatment. Cumulatively, we unveil that HSP90 inhibitors stimulate the translation of DNAJB4 through an epitranscriptomic mechanism

OR-041 Infection of Different Altitudes on College Students’ Body Shape

Objective Considering that guizhou is located in a plateau region with various gradient altitude,and we have never seen any relevant report on the study of different altitudes influence the students'physical fitness at home or abroad. the aim of this research is the author runs a normal physical fitness test on native 774 non-PE major students who all comes from different altitudes 774, so as to provide reference standard for promoting the health of the students group. Methods literature data, fitness testing, statistic, and logic analysis. Results 1、There was no obvious consistency between the height change of students in different atitudes indicating that the influence of different altitude environments on the height of students was not obvious.2、Most of the students on the plateau show the thickness of the skinfold is the thickest , while the thickness of the skinfold of students on the plain and the subplateau is different and irregular. 3. There was no significant difference in the chest circumference of the four groups of students at three altitudes, indicating that the environment at different altitudes had no significant influence on the development of the respiratory organs and chest muscles of the students. 4. The waist circumference of the three groups showed no obvious pattern, indicating that the environment at different altitude had no significant influence on the waist circumference. 5. The waist-hip range of female students on the plateau is relatively high, while other students are in the ideal range. 6. The BMI of all the students in the three places is within the range of 18.5 ~ 22.9, that is, all the students in the three places are in the normal range. Conclusions altitude has no significant effect on students'height, chest circumference, waist circumference and BMI. The thickness of skinfold of students on plateau is thicker than that of plain and subplateau students. The waist-hip range of female students on the plateau is relatively high, while other students are in the ideal range

Numerical Analysis of Partial Abrasion of the Straddle-type Monorail Vehicle running Tyre

The finite element model of the running tyre and the pre-stressed concrete (PC) track beam are created in the study. The wheel-rail contact status under the conditions such as acceleration or braking, lateral deviation, and roll is analysed. The wear law of the running tyre under the operating condition of driving on winding roads is discussed. The results show that the running tyre will unevenly wear when driving on the winding road; the smaller curve radius and the faster speed result in heavier and more uneven wear. There is a larger slip between the running tyre on the inner side of the curve and the rail surface, and this tyre has more uneven wear than the running tyre on the outer side of the curve. The research findings provide a theoretical basis for solving the problem of reducing the uneven wear of the running tyre

(2E,6E)-2,6-Bis(2,5-difluoro­benzyl­idene)cyclo­hexa­none

In the title compound, C20H14F4O, a derivative of curcumin, the dihedral angle between the two aromatic rings is 27.19 (13)°. The C=C double bonds have an E configuration

Conflict-Based Cross-View Consistency for Semi-Supervised Semantic Segmentation

Semi-supervised semantic segmentation (SSS) has recently gained increasing research interest as it can reduce the requirement for large-scale fully-annotated training data. The current methods often suffer from the confirmation bias from the pseudo-labelling process, which can be alleviated by the co-training framework. The current co-training-based SSS methods rely on hand-crafted perturbations to prevent the different sub-nets from collapsing into each other, but these artificial perturbations cannot lead to the optimal solution. In this work, we propose a new conflict-based cross-view consistency (CCVC) method based on a two-branch co-training framework which aims at enforcing the two sub-nets to learn informative features from irrelevant views. In particular, we first propose a new cross-view consistency (CVC) strategy that encourages the two sub-nets to learn distinct features from the same input by introducing a feature discrepancy loss, while these distinct features are expected to generate consistent prediction scores of the input. The CVC strategy helps to prevent the two sub-nets from stepping into the collapse. In addition, we further propose a conflict-based pseudo-labelling (CPL) method to guarantee the model will learn more useful information from conflicting predictions, which will lead to a stable training process. We validate our new CCVC approach on the SSS benchmark datasets where our method achieves new state-of-the-art performance. Our code is available at https://github.com/xiaoyao3302/CCVC.Comment: accepted by CVPR202

MULTI-PORT ELECTROMAGNETIC INTERFERENCE IMPROVEMENT USING HETEROGENEOUS PORTS

Techniques are provided herein for using different profiles on different ports for different radiation directions in multi-port projects. Because the superposition effect is weakened, the maximum radiation of a project is about 3dB smaller than those with uniform ports

Erythrocyte enrichment in hematopoietic progenitor cell cultures based on magnetic susceptibility of the hemoglobin

Using novel media formulations, it has been demonstrated that human placenta and umbilical cord blood-derived CD34+ cells can be expanded and differentiated into erythroid cells with high efficiency. However, obtaining mature and functional erythrocytes from the immature cell cultures with high purity and in an efficient manner remains a significant challenge. A distinguishing feature of a reticulocyte and maturing erythrocyte is the increasing concentration of hemoglobin and decreasing cell volume that results in increased cell magnetophoretic mobility (MM) when exposed to high magnetic fields and gradients, under anoxic conditions. Taking advantage of these initial observations, we studied a noninvasive (label-free) magnetic separation and analysis process to enrich and identify cultured functional erythrocytes. In addition to the magnetic cell separation and cell motion analysis in the magnetic field, the cell cultures were characterized for cell sedimentation rate, cell volume distributions using differential interference microscopy, immunophenotyping (glycophorin A), hemoglobin concentration and shear-induced deformability (elongation index, EI, by ektacytometry) to test for mature erythrocyte attributes. A commercial, packed column high-gradient magnetic separator (HGMS) was used for magnetic separation. The magnetically enriched fraction comprised 80% of the maturing cells (predominantly reticulocytes) that showed near 70% overlap of EI with the reference cord blood-derived RBC and over 50% overlap with the adult donor RBCs. The results demonstrate feasibility of label-free magnetic enrichment of erythrocyte fraction of CD34+ progenitor-derived cultures based on the presence of paramagnetic hemoglobin in the maturing erythrocytes. © 2012 Jin et al