Delineating the antigenotoxic and anticytotoxic potentials of 4-methylimidazole against ethyl methanesulfonate toxicity in bone marrow cell of swiss albino mice

4-Methylimidazole (4-MEI) is mostly used in beverages and coloring food, dark beers and common brands of cola drinks, which may contain more than 100 μg of this compound per 12-ounce serving. This study was aimed to investigate the antigenotoxic and anticytotoxic effects of 4-MEI (100, 130 and 160 mg/kg) against ethyl methanesulfonate (240 mg/kg) using chromosome aberrations (CAs) and Mitotic index (MI) tests in bone marrow cells of Swiss Albino Mice at 12 h and 24 h treatment periods. So, the t-test was used for the statistical analysis. In this research, 4-MEI at all concentrations for 12 h treatment period reduced chromosomal aberrations and at 130 and 160 mg/kg concentrations for 24 h treatment period increased chromosomal aberrations induced by EMS (240 mg/kg), but th ese reductions and increases were not significant. Also, intraperitoneal injection of 4-MEI at doses of 100, 130 and 160 mg/kg combined with EMS (240 mg/kg) showed that the mitotic index was decreased at 100 and 130 mg/kg for 12h and 130 mg/kg for 24 h treatment periods, when compared to positive sample (EMS), but did not show any statistically difference from the EMS treated group. It can be concluded that 4-MEI might not be antigenotoxic and protective effects in bone marrow cells of Swiss Albino Mice, because 4-MEI could not reduce the chromosomal aberrations induced by EMS

54/07/28 Why Don\u27t Police Quiz Top Suspect: An Editorial

This editorial, published two days after the conclusion of the Coroner\u27s Inquest, describes Sam as a proven liar who is being shielded by his family and demands that he be taken to police headquarters for further questioning. It declares that if average people\u27 were involved in this murder it would have been cleaned up long ago.https://engagedscholarship.csuohio.edu/sheppard_maxwell_articles/1004/thumbnail.jp

Applied Filtered Density Function

An overview is presented of recent advances in the filtered density function (FDF) modeling and simulation of turbulent combustion. The review is focused on the developments that have facilitated the FDF to be broadly applied in large eddy simulation (LES) of practical flows. These are primarily the development of a new Lagrangian Monte Carlo solver for the FDF, and the implementation of this solver on Eulerian domains portrayed by unstructured grids. With these developments, it is now much easier to apply FDF for predictions of reacting flows in complex geometrical configurations

Interaction Coverage Meets Path Coverage by SMT Constraint Solving

Abstract. We present a novel approach for generating interaction combinations based on SMT constraint resolution. Our approach can generate maximal inter-action coverage in the presence of general constraints as supported by the un-derlying solver. It supports seeding with general predicates, which allows us to combine it with path exploration such that both interaction and path coverage goals can be met. Our approach is motivated by the application to behavioral model-based testing in the Spec Explorer tool, where parameter combinations must be generated such that all path conditions of a model action have at least one combination which enables the path. It is applied in a large-scale project for model-based quality assurance of interoperability documentation at Microsoft.

Times of Minima of Some Eclipsing Binaries

We present new times of minima in the light curves of some eclipsing binarie

Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV

Results are presented from a search for a W' boson using a dataset corresponding to 5.0 inverse femtobarns of integrated luminosity collected during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV. The W' boson is modeled as a heavy W boson, but different scenarios for the couplings to fermions are considered, involving both left-handed and right-handed chiral projections of the fermions, as well as an arbitrary mixture of the two. The search is performed in the decay channel W' to t b, leading to a final state signature with a single lepton (e, mu), missing transverse energy, and jets, at least one of which is tagged as a b-jet. A W' boson that couples to fermions with the same coupling constant as the W, but to the right-handed rather than left-handed chiral projections, is excluded for masses below 1.85 TeV at the 95% confidence level. For the first time using LHC data, constraints on the W' gauge coupling for a set of left- and right-handed coupling combinations have been placed. These results represent a significant improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe

Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV

A search for a Higgs boson decaying into two photons is described. The analysis is performed using a dataset recorded by the CMS experiment at the LHC from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross section of the standard model Higgs boson decaying to two photons. The expected exclusion limit at 95% confidence level is between 1.4 and 2.4 times the standard model cross section in the mass range between 110 and 150 GeV. The analysis of the data excludes, at 95% confidence level, the standard model Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The largest excess of events above the expected standard model background is observed for a Higgs boson mass hypothesis of 124 GeV with a local significance of 3.1 sigma. The global significance of observing an excess with a local significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is estimated to be 1.8 sigma. More data are required to ascertain the origin of this excess.Comment: Submitted to Physics Letters