Accuracy improvement of small defect detection for ultrasonic inspection by using scientific visual analysis

When we diagnose the structural integrity of a steel member in service and evaluate its remaining life time, we need to improve analyzing method to get the accurate information of a internal defect of a member. And by the recent demand for high level quality control of welding of steel joint the accuracy improvement of defect detection in the image display became essential in nondestructive evaluation (NDE)[1][2][3]. So far the defect information obtained by an ultrasonic test is displayed in several ways and A-scan and B-scan displays are commonly used in a field inspection and C-scan display is used in laboratory test of the steel structural member[4][5]

High levels of oxidatively generated DNA damage 8,5'-cyclo-2'-deoxyadenosine accumulate in the brain tissues of xeroderma pigmentosum group A gene-knockout mice.

Xeroderma pigmentosum (XP) is a genetic disorder associated with defects in nucleotide excision repair, a pathway that eliminates a wide variety of helix-distorting DNA lesions, including ultraviolet-induced pyrimidine dimers. In addition to skin diseases in sun-exposed areas, approximately 25% of XP patients develop progressive neurological disease, which has been hypothesized to be associated with the accumulation of an oxidatively generated type of DNA damage called purine 8,5'-cyclo-2'-deoxynucleoside (cyclopurine). However, that hypothesis has not been verified. In this study, we tested that hypothesis by using the XP group A gene-knockout (Xpa-/-) mouse model. To quantify cyclopurine lesions in this model, we previously established an enzyme-linked immunosorbent assay (ELISA) using a monoclonal antibody (CdA-1) that specifically recognizes 8,5'-cyclo-2'-deoxyadenosine (cyclo-dA). By optimizing conditions, we increased the ELISA sensitivity to a detection limit of ˜one cyclo-dA lesion/106 nucleosides. The improved ELISA revealed that cyclo-dA lesions accumulate with age in the brain tissues of Xpa-/- and of wild-type (wt) mice, but there were significantly more cyclo-dA lesions in Xpa-/- mice than in wt mice at 6, 24 and 29 months of age. These findings are consistent with the long-standing hypothesis that the age-dependent accumulation of endogenous cyclopurine lesions in the brain may be critical for XP neurological abnormalities

Crystal structure of phenolphthalein

金沢大学大学院自然科学研究科先端機能物質金沢大学工学

Development of a Multifunctional Lightweight Membrane with a High Specific Power Generation Capacity

As a lighter power generation system, Japan Aerospace Exploration Agency (JAXA) and Sakase Adtech Corp. are developing a demonstrator component named “Harvesting Energy with Lightweight Integrated Origami Structure” (HELIOS), which is a deployable lightweight membrane structure. HELIOS has solar arrays on its surface and demonstrates the technology which enables higher specific power generation capacity compared to the conventional solar array panels. The membrane also has communication antennas, showing the potency of lightweight membrane’s multifunctionality such as large data transmitting by 5G antennas and high-resolution observation by interferometer antennas. This paper presents the component’s concept and design, and the expected achievements

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In order to find the best condition to prepare Ant-iinflammatory enzyme tablets, the effect of dilluents, wetting agents, disintegrators, binders and compression on several proteinase as Antiinflammatory enzymes were investigated. Dilluents used in this experiment had no effect on enzyme activities, and wetting agents in high concentration gave little effect. Heat to dry granulles used for tablet have no effect if it was below 60°. First pressure when the enzymes were compressed caused comparatively large decrease of the activities and at second pressure less inactivation was observed. With solvent used in coating process of the tablet, methanol caused the inactivation and others gave no effect