Povos ancestrais, América do Sul e Caribe: epistemologias e poéticas visuais na formação de engenheiros

Objetivos desta reflexão: tornar conhecidas epistemologias e estéticas visuais de povos ancestrais da América do Sul e Caribe, visando re-escrever a história da Engenharia dessa parte do mundo; oferecer imagens de soluções dadas a problemas de engenharia e arquitetura, demonstrando a importância epistemológica e estética para a condição humana. Com base teórica em Bachelard (2006), teoria e metodologia mitohermenêutica, analisa-se o trajeto antropológico e ao mesmo tempo mudança epistemológica de alunos, pela construção de projeto de pesquisa. Concluindo, questiona-se o fato do Brasil jamais ter considerado necessário a população não indígena aprender epistemologias e estéticas ancestrais. Propõe-se a criar Rede de Conhecimentos. Palavras-chave: Epistemologia de Povos Ancestrais. América do Sul e Caribe. Formação em Engenharia. Rede de Conhecimentos

Propuesta de implementación de control interno y su incidencia en los costos laborales de la empresa Olva Courier S.A.C. sede Callao del año 2017

Lo que se busca en el presente trabajo de investigación es demostrar la manera en que incide la implementación del control interno en los costos laborales, observando las deficiencias y sus causas para así de esta manera tratar los riesgos más relevantes que podamos analizar a fin de contribuir en el resguardo de los recursos de la empresa. El tipo de investigación por su naturaleza es Básica - No Experimental de Corte Transversal – Descriptiva, siendo la población la empresa Olva Courier S.A.C. Sede Callao y como muestra los integrantes del área de Recursos Humanos. Las técnicas utilizadas para la recopilación de información son la observación, la encuesta y el análisis documental. Los resultados permitieron identificar deficiencias en el área de recursos humanos en aspectos como ausencia de auditoría interna, carencia de manuales internos, desconocimientos de procesos administrativos, falta de capacitación continua al personal, entre otros. Finalmente, las deficiencias identificadas en los resultados afectan de manera directa en los costos laborales, validando nuestras hipótesis y demostrando la importancia de la implementación de un sistema de control interno basado en las técnicas del Marco Integrado COSO 1 – 2013 para beneficio de la empresa Olva Courier S.A.C.What is sought in this research work is to demonstrate the way in which the implementation of internal control affects labor costs, observing the deficiencies and their causes in order to treat the most relevant risks that we can analyze in order to contribute in the safeguarding of the company's resources. The type of research by its nature is Basic - Non-Experimental Cross-Sectional - Descriptive, being the population the company Olva Courier S.A.C. Callao headquarters and as shown by the members of the Human Resources área. The techniques used to collect information are observation, survey, and documentary analysis. The results made it possible to identify deficiencies in the human resources area in aspects such as absence of internal auditing, lack of internal manuals, ignorance of administrative processes, lack of continuous training for personnel, among others. Finally, the deficiencies identified in the results directly affect labor costs, validating our hypotheses and demonstrating the importance of the implementation of an internal control system based on the techniques of the Integrated Framework COSO 1 - 2013 for the benefit of the company Olva Courier S.A.C

CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants

Purpose To expand the recent description of a new neurodevelopmental syndrome related to alterations in CDK19. Methods Individuals were identified through international collaboration. Functional studies included autophosphorylation assays for CDK19 Gly28Arg and Tyr32His variants and in vivo zebrafish assays of the CDK19(G28R) and CDK19(Y32H). Results We describe 11 unrelated individuals (age range: 9 months to 14 years) with de novo missense variants mapped to the kinase domain of CDK19, including two recurrent changes at residues Tyr32 and Gly28. In vitro autophosphorylation and substrate phosphorylation assays revealed that kinase activity of protein was lower for p.Gly28Arg and higher for p.Tyr32His substitutions compared with that of the wild-type protein. Injection of CDK19 messenger RNA (mRNA) with either the Tyr32His or the Gly28Arg variants using in vivo zebrafish model significantly increased fraction of embryos with morphological abnormalities. Overall, the phenotype of the now 14 individuals with CDK19-related disorder includes universal developmental delay and facial dysmorphism, hypotonia (79%), seizures (64%), ophthalmologic anomalies (64%), and autism/autistic traits (56%). Conclusion CDK19 de novo missense variants are responsible for a novel neurodevelopmental disorder. Both kinase assay and zebrafish experiments showed that the pathogenetic mechanism may be more diverse than previously thought.Peer reviewe

No supportive evidence for TIA1 gene mutations in a European cohort of ALS-FTD spectrum patients

We evaluated the genetic contribution of the T cell-erestricted intracellular antigen-1 gene (TIA1) in a European cohort of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) patients. Exonic resequencing of TIA1 in 1120 patients (693 FTD, 341 ALS, 86 FTD-ALS) and 1039 controls identified in total 5 rare heterozygous missense variants, affecting the TIA1 low-complexity domain (LCD). Only 1 missense variant, p.Met290Thr, identified in a familial FTD patient with disease onset at 64 years, was absent from controls yet received a combined annotation-dependent depletion score of 11.42. By contrast, 3 of the 4 variants also detected in unaffected controls, p.Val294Glu, p.Gln318Arg, and p.Ala381Thr, had combined annotation-dependent depletion scores greater than 20. Our findings in a large European patient-control series indicate that variants in TIA1 are not a common cause of ALS and FTD. The observation of recurring TIA1 missense variants in unaffected individuals lead us to conclude that the exact genetic contribution of TIA1 to ALS and FTD pathogenesis remains to be further elucidated

Correlations in STAR: interferometry and event structure

STAR observes a complex picture of RHIC collisions where correlation effects of different origins -- initial state geometry, semi-hard scattering, hadronization, as well as final state interactions such as quantum intensity interference -- coexist. Presenting the measurements of flow, mini-jet deformation, modified hadronization, and the Hanbury Brown and Twiss effect, we trace the history of the system from the initial to the final state. The resulting picture is discussed in the context of identifying the relevant degrees of freedom and the likely equilibration mechanism.Comment: 8 pages, 6 figures, plenary talk at the 5th International Conference on Physics and Astrophysics of Quark Gluon Plasma, to appear in Journal of Physics G (http://www.iop.org

Strangelet search at RHIC

Two position sensitive Shower Maximum Detector (SMDs) for Zero-Degree Calorimeters (ZDCs) were installed by STAR before run 2004 at both upstream and downstream from the interaction point along the beam axis where particles with small rigidity are swept away by strong magnetic field. The ZDC-SMDs provides information about neutral energy deposition as a function of transverse position in ZDCs. We report the preliminary results of strangelet search from a triggered data-set sampling 100 million Au+Au collisions at top RHIC energy.Comment: Strange Quark Matter 2004 conference proceedin

Neutral Kaon Interferometry in Au+Au collisions at sqrt(s_NN) = 200 GeV

We present the first statistically meaningful results from two-K0s interferometry in heavy-ion collisions. A model that takes the effect of the strong interaction into account has been used to fit the measured correlation function. The effects of single and coupled channel were explored. At the mean transverse mass m_T = 1.07 GeV, we obtain the values R = 4.09 +/- 0.46 (stat.) +/- 0.31 (sys) fm and lambda = 0.92 +/- 0.23 (stat) +/- 0.13 (sys), where R and lambda are the invariant radius and chaoticity parameters respectively. The results are qualitatively consistent with m_T systematics established with pions in a scenario characterized by a strong collective flow.Comment: 11 pages, 10 figure

Azimuthal anisotropy and correlations at large transverse momenta in p+p and Au+Au collisions at sqrt[sNN] = 200 GeV

Results on high transverse momentum charged particle emission with respect to the reaction plane are presented for Au+Au collisions at sqrt[sNN]=200 GeV. Two- and four-particle correlations results are presented as well as a comparison of azimuthal correlations in Au+Au collisions to those in p+p at the same energy. The elliptic anisotropy v2 is found to reach its maximum at pt~3 GeV/c, then decrease slowly and remain significant up to pt ~ 7-10 GeV/c. Stronger suppression is found in the back-to-back high-pt particle correlations for particles emitted out of plane compared to those emitted in plane. The centrality dependence of v2 at intermediate pt is compared to simple models based on jet quenching

Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry.

BACKGROUND It remains elusive how the characteristics, the course of disease, the clinical management and the outcomes of critically ill COVID-19 patients admitted to intensive care units (ICU) worldwide have changed over the course of the pandemic. METHODS Prospective, observational registry constituted by 90 ICUs across 22 countries worldwide including patients with a laboratory-confirmed, critical presentation of COVID-19 requiring advanced organ support. Hierarchical, generalized linear mixed-effect models accounting for hospital and country variability were employed to analyse the continuous evolution of the studied variables over the pandemic. RESULTS Four thousand forty-one patients were included from March 2020 to September 2021. Over this period, the age of the admitted patients (62 [95% CI 60-63] years vs 64 [62-66] years, p < 0.001) and the severity of organ dysfunction at ICU admission decreased (Sequential Organ Failure Assessment 8.2 [7.6-9.0] vs 5.8 [5.3-6.4], p < 0.001) and increased, while more female patients (26 [23-29]% vs 41 [35-48]%, p < 0.001) were admitted. The time span between symptom onset and hospitalization as well as ICU admission became longer later in the pandemic (6.7 [6.2-7.2| days vs 9.7 [8.9-10.5] days, p < 0.001). The PaO2/FiO2 at admission was lower (132 [123-141] mmHg vs 101 [91-113] mmHg, p < 0.001) but showed faster improvements over the initial 5 days of ICU stay in late 2021 compared to early 2020 (34 [20-48] mmHg vs 70 [41-100] mmHg, p = 0.05). The number of patients treated with steroids and tocilizumab increased, while the use of therapeutic anticoagulation presented an inverse U-shaped behaviour over the course of the pandemic. The proportion of patients treated with high-flow oxygen (5 [4-7]% vs 20 [14-29], p < 0.001) and non-invasive mechanical ventilation (14 [11-18]% vs 24 [17-33]%, p < 0.001) throughout the pandemic increased concomitant to a decrease in invasive mechanical ventilation (82 [76-86]% vs 74 [64-82]%, p < 0.001). The ICU mortality (23 [19-26]% vs 17 [12-25]%, p < 0.001) and length of stay (14 [13-16] days vs 11 [10-13] days, p < 0.001) decreased over 19 months of the pandemic. CONCLUSION Characteristics and disease course of critically ill COVID-19 patients have continuously evolved, concomitant to the clinical management, throughout the pandemic leading to a younger, less severely ill ICU population with distinctly different clinical, pulmonary and inflammatory presentations than at the onset of the pandemic