Platelet glycoprotein IIb/IIIa receptor blockers in clinical practice

I n this thesis, platelet glycoprotein (GP) IIb/IIIa receptor blockers are discussed for use in patients with acute coronary syndromes without persistent ST-segment elevation but also for use in patients with overt myocardial infarction. Furthermore, the role of intervention, and more specifically, the role of timing of percutaneous coronary intervention is descnOed in patients 'With acute coronary syndromes without persistent ST-segment elevation incorporating use of platelet GP IIb/IIIa receptor antagonists

Which options fit best? Operationalizing the socio-ecological niche concept

Article Purchased; Published: 1st August 2016The large diversity of farms and farming systems in sub-Saharan Africa calls for agricultural improvement options that are adapted to the context in which smallholder farmers operate. The socio-ecological niche concept incorporates the agro-ecological, socio-cultural, economic and institutional dimensions and the multiple levels of this context in order to identify which options fit best. In this paper, we illustrate how farming systems analysis, following the DEED cycle of Describe, Explain, Explore and Design, and embedding co-learning amongst researchers, farmers and other stakeholders, helps to operationalize the socio-ecological niche concept. Examples illustrate how farm typologies, detailed farm characterization and on-farm experimental work, in combination with modelling and participatory approaches inform the matching of options to the context at regional, village, farm and field level. Recommendation domains at these gradually finer levels form the basis for gradually more detailed baskets of options from which farmers and other stakeholders may choose, test and adjust to their specific needs. Tailored options identified through the DEED cycle proof to be more relevant, feasible and performant as compared to blanket recommendations in terms of both researcher and farmer-identified criteria. As part of DEED, on-farm experiments are particularly useful in revealing constraints and risks faced by farmers. We show that targeting options to the niches in which they perform best, helps to reduce this risk. Whereas the conclusions of our work about the potential for improving smallholders’ livelihoods are often sobering, farming systems analysis allows substantiating the limitations of technological options, thus highlighting the need for enabling policies and institutions that may improve the larger-scale context and increase the uptake potential of options

How do climbing beans fit in farming systems of the eastern highlands of Uganda? Understanding opportunities and constraints at farm level

Open Access Article; Published online: 19 June 2018Climbing beans offer potential for sustainable intensification in the East-African highlands, but their introduction requires a major change in the cropping system compared with the commonly grown bush bean. We explored farm-level opportunities, constraints and trade-offs for climbing bean cultivation in the eastern highlands of Uganda. We established current food self-sufficiency, income, investment costs and labour, and assessed the ex-ante, farm-level impact of four climbing bean options on these indicators. Input for this assessment were a detailed characterization of 16 farms of four types, and on-farm, experimental data of adaptation trials of climbing bean. Climbing beans generally improved food self-sufficiency and income, but often required increased financial investment and always demanded more labour than current farm configurations. Opportunities for integration of climbing beans on small farms were limited. Although some of the poorest farmers accrued the largest absolute benefits from climbing beans, their ability to make the necessary investments is questionable. The analysis was translated into a simple-to-use modelling tool to enable participatory analysis of the outcomes with farmers of the four farm types to understand their perspectives and decision-making. The discussions revealed a recent increase in market prices for climbing bean resulting in growing interest in their cultivation in the eastern highlands. A lack of seed and stakes was limiting climbing bean cultivation, and a sufficient amount of climbing bean seed needs to be ensured through strengthening of farmer cooperatives and improved storage