Techniques for the non-destructive and continuous analysis of sediment cores. Application in the Iberian continental margin

Sediment sequences are the most valuable record of long-term environmental conditions at local, regional and/or global scales. Consequently, they are amongst the best archives of the climatic and oceanographic history of the Earth. In the last few decades a strong effort has been made, both in terms of quantity and quality, to improve our knowledge regarding the evolution of our planet from marine and lake sediment records, and also from other records such as ice cores. Such an effort requires reinforcing the geographical coverage and achieving the highest possible robustness in the reconstruction of past environments. Such a target requires the optimization of the time resolution of the records and reconstructions so that fast, high frequency shifts, such as those occurring nowadays due to the on-going global warming, can be disentangled. Beyond paleoenvironmental research, other disciplines have also contributed significantly to the fast growing number of sediment cores already available worldwide. Knowing the physical state and the chemical composition of sedimentary deposits is essential for land management purposes and for many industrial applications. A number of key technological developments are now allowing the acquisition for the first time of massive amounts of multiple parameters from sediment cores in a non-destructive, fast, continuous, repetitive and high-resolution form. In this paper we provide an overview of the state-of-the-art continuous and non-destructive analytical techniques used by the geoscientific community for the study of sediment cores and we present some examples of the application of these methods in several studies carried out around the Iberian Margin

Las Telecomunicaciones fotónicas hacen posible super-internet

Peer Reviewe

Role of color doppler imaging in early diagnosis and prediction of progression in glaucoma

This longitudinal and prospective study analyzes the ability of orbital blood flow measured by color Doppler imaging (CDI) to predict glaucoma progression in patients with glaucoma risk factors. Patients with normal perimetry but having glaucoma risk factors and patients in the initial phase of glaucoma were prospectively included in the study and divided, after a five-year follow-up, into two groups: “Progression” and “No Progression” based on the changes in the Moorfields regression analysis (MRA) classification of Heidelberg retina tomograph (HRT). An orbital CDI was performed in all patients and the parameters obtained were correlated with changes in HRT. A logistic discrimination function (LDF) was calculated for ophthalmic artery (OA) and central retinal artery (CRA) parameters. Receiver operating characteristics curves (ROC) were used to assess the usefulness of LDFs to predict glaucomatous progression. A total of 71 eyes were included. End-diastolic velocity, time-averaged velocity, and resistive index in the OA and CRA were significantly different ( ) between the Progression and No Progression groups. The area under the ROC curves calculated for both LDFs was of 0.695 (OA) and 0.624 (CRA). More studies are needed to evaluate the ability of CDI to perform early diagnosis and to predict progression in glaucoma in eyes

Function of cofactor Akirin2 in the regulation of gene expression in model human Caucasian neutrophil-like HL60 cells

The Akirin family of transcription cofactors are involved throughout the metazoan in the regulation of different biological processes (BPs) such as immunity, interdigital regression, muscle and neural development. Akirin do not have catalytic or DNA-binding capability and exert its regulatory function primarily through interacting proteins such as transcription factors, chromatin remodelers, and RNA-associated proteins. In the present study, we focused on the human Akirin2 regulome and interactome in neutrophil-like model human Caucasian promyelocytic leukemia HL60 cells. Our hypothesis is that metazoan evolved to have Akirin2 functional complements and different Akirin2-mediated mechanisms for the regulation of gene expression. To address this hypothesis, experiments were conducted using transcriptomics, proteomics and systems biology approaches in akirin2 knockdown and wildtype (WT) HL60 cells to characterize Akirin2 gene/protein targets, functional complements and to provide evidence of different mechanisms that may be involved in Akirin2-mediated regulation of gene expression. The results revealed Akirin2 gene/protein targets in multiple BPs with higher representation of immunity and identified immune response genes as candidate Akirin2 functional complements. In addition to linking chromatin remodelers with transcriptional activation, Akirin2 also interacts with histone H3.1 for regulation of gene expression. © 2021 The Author(s)

Evaluation of Near-Surface Air Temperature from Reanalysis over the United States and Ukraine: Application to Winter Wheat Yield Forecasting

In this work we evaluate the near-surface air temperature datasets from the ERA-Interim, JRA55, MERRA2, NCEP1, and NCEP2 reanalysis projects. Reanalysis data were first compared to observations from weather stations located on wheat areas of the United States and Ukraine, and then evaluated in the context of a winter wheat yield forecast model. Results from the comparison with weather station data showed that all datasets performed well (r2>0.95) and that more modern reanalysis such as ERAI had lower errors (RMSD ~ 0.9) than the older, lower resolution datasets like NCEP1 (RMSD ~ 2.4). We also analyze the impact of using surface air temperature data from different reanalysis products on the estimations made by a winter wheat yield forecast model. The forecast model uses information of the accumulated Growing Degree Day (GDD) during the growing season to estimate the peak NDVI signal. When the temperature data from the different reanalysis projects were used in the yield model to compute the accumulated GDD and forecast the winter wheat yield, the results showed smaller variations between obtained values, with differences in yield forecast error of around 2% in the most extreme case. These results suggest that the impact of temperature discrepancies between datasets in the yield forecast model get diminished as the values are accumulated through the growing season

The Role of Canyons in Strata Formation

This paper provides a spatial and temporal multi-scale approach of European submarine canyons. We fi rst present the long-term geologic view of European margins as related to controls on submarine canyon development. Then we discuss the extent to which submarine canyon systems resemble river systems because both essentially form drainage networks. Finally, we deal with the hortest-term, highestresolution scale to get a fl avor of the current functioning and health of modern submarine canyons in the northwestern Mediterranean Sea. Submarine canyons are unique features of the seafl oor whose existence was known by European fi shermen centuries ago, especially for those canyons that have their heads at short distance from shoreline. Popular names given to specifi c canyons in the different languages spoken in European coastal communities refer to the concepts of a"deep" or"trench." In the old times it was also common thinking that submarine canyons where so deep that nobody could measure their depth or even that they had no bottom. Submarine canyons are just one of the seven different types of seafl oor valleys identifi ed by Shepard (1973) in his pioneering morphogenetic classifi cation. Shepard (1973) defined submarine canyons as"steep-walled, sinuous valleys, with V-shaped cross sections, and relief comparable even to the largest of land canyons; tributaries are found in most of the canyons and rock outcrops abound on their walls." Canyons are features typical of continental slopes with their upper reaches and heads cut into the continental shelf

Soliton Interactions in Perturbed Nonlinear Schroedinger Equations

We use multiscale perturbation theory in conjunction with the inverse scattering transform to study the interaction of a number of solitons of the cubic nonlinear Schroedinger equation under the influence of a small correction to the nonlinear potential. We assume that the solitons are all moving with the same velocity at the initial instant; this maximizes the effect each soliton has on the others as a consequence of the perturbation. Over the long time scales that we consider, the amplitudes of the solitons remain fixed, while their center of mass coordinates obey Newton's equations with a force law for which we present an integral formula. For the interaction of two solitons with a quintic perturbation term we present more details since symmetries -- one related to the form of the perturbation and one related to the small number of particles involved -- allow the problem to be reduced to a one-dimensional one with a single parameter, an effective mass. The main results include calculations of the binding energy and oscillation frequency of nearby solitons in the stable case when the perturbation is an attractive correction to the potential and of the asymptotic "ejection" velocity in the unstable case. Numerical experiments illustrate the accuracy of the perturbative calculations and indicate their range of validity.Comment: 28 pages, 7 figures, Submitted to Phys Rev E Revised: 21 pages, 6 figures, To appear in Phys Rev E (many displayed equations moved inline to shorten manuscript

Protein kinase B (AKT) upregulation and Thy-1-α_vβ₃ integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis.

In response to brain injury or inflammation, astrocytes undergo hypertrophy, proliferate, and migrate to the damaged zone. These changes, collectively known as "astrogliosis", initially protect the brain; however, astrogliosis can also cause neuronal dysfunction. Additionally, these astrocytes undergo intracellular changes involving alterations in the expression and localization of many proteins, including α <sub>v</sub> β <sub>3</sub> integrin. Our previous reports indicate that Thy-1, a neuronal glycoprotein, binds to this integrin inducing Connexin43 (Cx43) hemichannel (HC) opening, ATP release, and astrocyte migration. Despite such insight, important links and molecular events leading to astrogliosis remain to be defined. Using bioinformatics approaches, we analyzed different Gene Expression Omnibus datasets to identify changes occurring in reactive astrocytes as compared to astrocytes from the normal mouse brain. In silico analysis was validated by both qRT-PCR and immunoblotting using reactive astrocyte cultures from the normal rat brain treated with TNF and from the brain of a hSOD1 <sup>G93A</sup> transgenic mouse model. We evaluated the phosphorylation of Cx43 serine residue 373 (S373) by AKT and ATP release as a functional assay for HC opening. In vivo experiments were also performed with an AKT inhibitor (AKTi). The bioinformatics analysis revealed that genes of the PI3K/AKT signaling pathway were among the most significantly altered in reactive astrocytes. mRNA and protein levels of PI3K, AKT, as well as Cx43, were elevated in reactive astrocytes from normal rats and from hSOD1 <sup>G93A</sup> transgenic mice, as compared to controls. In vitro, reactive astrocytes stimulated with Thy-1 responded by activating AKT, which phosphorylated S373Cx43. Increased pS373Cx43 augmented the release of ATP to the extracellular medium and AKTi inhibited these Thy-1-induced responses. Furthermore, in an in vivo model of inflammation (brain damage), AKTi decreased the levels of astrocyte reactivity markers and S373Cx43 phosphorylation. Here, we identify changes in the PI3K/AKT molecular signaling network and show how they participate in astrogliosis by regulating the HC protein Cx43. Moreover, because HC opening and ATP release are important in astrocyte reactivity, the phosphorylation of Cx43 by AKT and the associated increase in ATP release identify a potential therapeutic window of opportunity to limit the adverse effects of astrogliosis