Oscillations of Dynamic Topography in the Eastern Equatorial Pacific

For 14 months in 1980–81, surface dynamic height was monitored with inverted echo sounders at five sites from 0 to 9°N along 110°W. These records show that the SEC/NECC equatorial current system was well-developed during the boreal summer and fall, but weak and irregular during winter and spring when westward flow associated with the NEC extended as far south as 6°N. Superimposed on the mean dynamic topography of this region are energetic 20-to-80-day oscillations, longer periods being associated with higher latitudes. Near the equatorial ridge (∼5°N), these oscillations have predominantly monthly periods, and amplitude of ∼10 dyn cm comparable to the mean dynamic-height difference across the NECC. The broad in-phase meridional extent of these monthly oscillations implies that the principal mode of ridge variation is vertical undulation rather than meridional meandering, producing large in-phase monthly modulations in transport of the SEC and NECC. Oscillations or the equatorial ridge are correlated with propagating ∼1000-km wavelength sea surface temperature (SST) wave patterns observed in satellite infrared imagery. Passage of a northerly SST crest on the equatorial front at 110°W corresponds to a dynamic height minimum on the equatorial ridge. The relative phase and trochoidal shape of these crests is explained kinematically by superposition of the observed mean and oscillatory dynamic-height fields

Engrailed-2 (EN2) - a novel biomarker in epithelial ovarian cancer

YesBackground: Epithelial ovarian cancer is a common malignancy, with no clinically approved diagnostic biomarker. Engrailed-2 (EN2) is a homeodomain-containing transcription factor, essential during embryological neural development, which is dysregulated in several cancer types. We evaluated the expression of EN2 in Epithelial ovarian cancer, and reviewed its role as a biomarker. Methods: We evaluated 8 Epithelial ovarian cancer cell lines, along with > 100 surgical specimens from the Royal Surrey County Hospital (2009–2014). In total, 108 tumours and 5 normal tissue specimens were collected. En2 mRNA was evaluated by semi-quantitative RT-PCR. Histological sub-type, and platinum-sensitive/−resistant status were compared. Protein expression was assessed in cell lines (immunofluorescence), and in > 150 tumours (immunohistochemistry). Results: En2 mRNA expression was elevated in serous ovarian tumours compared with normal ovary (p < 0.001), particularly in high-grade serous ovarian cancer (p < 0.0001) and in platinum-resistant tumours (p = 0.0232). Median Overall Survival and Progression-free Survival were reduced with high En2 expression (OS = 28 vs 42 months, p = 0.0329; PFS = 8 vs 27 months; p = 0.0004). Positive cytoplasmic EN2 staining was demonstrated in 78% of Epithelial ovarian cancers, with absence in normal ovary. EN2 positive high-grade serous ovarian cancer patients had a shorter PFS (10 vs 17.5 months; p = 0.0103). Conclusion: The EN2 transcription factor is a novel ovarian cancer biomarker. It demonstrates prognostic value, correlating with worse Overall Survival and Progression-free Survival. It is hoped that further work will validate its use as a biomarker, and provide insight into the role of EN2 in the development, progression and spread of ovarian cancer.Oncology Research and Development Departments at the Royal Surrey County Hospital and the University of Surre

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

sea-level rise On the rate and causes of twentieth century References Rapid response On the rate and causes of twentieth century sea-level rise

Respond to this article Email alerting service here in the box at the top right-hand corner of the article or click . In contrast, values based on the processes mostly responsible for GSLR-mass increase (from mountain glaciers and the great high latitude ice masses) and volume increase (expansion due to ocean warming)-fall below this range. Either the gauge estimates are too high, or one (or both) of the component estimates is too low. Gauge estimates of GSLR have been in dispute for several decades because of vertical land movements, especially due to glacial isostatic adjustment (GIA). More recently, the possibility has been raised that coastal tide-gauges measure exaggerated rates of sea-level rise because of localized ocean warming. Presented here are two approaches to a resolution of these problems. The first is morphological, based on the limiting values of observed trends of twentieth century relative sea-level rise as a function of distance from the centres of the ice loads at last glacial maximum. This observational approach, which does not depend on a geophysical model of GIA, supports values of GSLR near 2 mm yr K1 . The second approach involves an analysis of long records of tide-gauge and hydrographic (in situ temperature and salinity) observations in the Pacific and Atlantic Oceans. It was found that sea-level trends from tide-gauges, which reflect both mass and volume change, are 2-3 times higher than rates based on hydrographic data which reveal only volume change. These results support those studies that put the twentieth century rate near 2 mm yr K1 , thereby indicating that mass increase plays a much larger role than ocean warming in twentieth century GSLR

Student, Staff, and Faculty Perspectives on Intimate Partner and Sexual Violence on 3 Public University Campuses: Protocol for the UC Speaks Up Study and Preliminary Results

BackgroundIntimate partner and sexual violence are pervasive public health issues on college and university campuses in the United States. Research is recommended for creating and maintaining effective, relevant, and acceptable prevention programs and response services for student survivors. ObjectiveThe University of California (UC) Speaks Up study aims to examine factors contributing to intimate partner and sexual violence on 3 UC campuses and use the findings to develop and test interventions and policies to prevent violence, promote health, and lay the groundwork for subsequent large-scale quantitative research. MethodsA mixed methods study was conducted at UC Los Angeles, UC San Diego, and UC Santa Barbara. Phase I (2017-2020) involved a resource audit; cultural consensus modeling of students’ perceptions of sexual consent; in-depth interviews (IDIs) and focus group discussions with students to understand perceptions of campus environment related to experiences as well as prevention of and responses to violence; and IDIs with faculty, staff, and community stakeholders to investigate institutional and community arrangements influencing students’ lives and experiences. Phase II (2020-ongoing) involves IDIs with student survivors to assess the use and perceptions of campus and community services. Qualitative content analysis is used to generate substantive codes and subthemes that emerge, using a thematic analysis approach. ResultsIn January 2019, we conducted 149 free-listing interviews and 214 web-based surveys with undergraduate and graduate and professional students for the cultural consensus modeling. Between February 2019 and June 2019, 179 IDIs were conducted with 86 (48%) undergraduate students, 21 (11.7%) graduate and professional students, 34 (19%) staff members, 27 (15.1%) faculty members, and 11 (6.1%) community stakeholders, and 35 focus group discussions (27/35, 77% with undergraduate students and 8/35, 23% with graduate and professional students) were conducted with 201 participants. Since September 2020, 50% (15/30) of the planned student survivor interviews have been conducted. This segment of data collection was disrupted by the COVID-19 pandemic. Recruitment is ongoing. ConclusionsData analysis and phase II data collection are ongoing. The findings will be used to develop and test interventions for preventing violence, promoting health and well-being, and ensuring that survivor services are relevant and acceptable to and meet the needs of all individuals in the campus community, including those who are typically understudied. The findings will also be used to prepare for rigorous, UC–system-wide public health prevention research. International Registered Report Identifier (IRRID)DERR1-10.2196/3118

Long Waves in the Equatorial Pacific Ocean

Westward traveling waves, with a period of 3 weeks and a wavelength of ∼1000 km, are observed intermittently in the central and eastern equatorial Pacific Ocean (see cover). The waves were first detected in 1975 in satellite measurements of the sea surface temperature [Legeckis, 1977]. Since then, additional measurements (under the auspices of the NOAA program Equatorial Pacific Ocean Climate Studies (EPOCS)) with a variety of instruments—drifting buoys, current meters and temperature sensors on moorings, and inverted echo sounders—have provided considerable information about these waves and have confirmed the hypothesis that they are caused by instabilities associated primarily with the latitudinal shear of the surface currents near the equator [Philander, 1978a; Cox, 1980]