Short and efficient synthesis of fluorinated δ-lactams

The diastereoselective synthesis of fluorinated δ-lactams has been achieved through an efficient five step process. The route can tolerate a range of functionalities, and provides a quick route for the generation of new fluorinated medicinal building blocks

Meeting the requirements of both classroom-based and systemic assessment of mathematics proficiency: the potential of Rasch measurement theory

The challenges inherent in assessing mathematical proficiency depend on a number of factors, amongst which are an explicit view of what constitutes mathematical proficiency, an understanding of how children learn and the purpose and function of teaching. All of these factors impact on the choice of approach to assessment. In this article we distinguish between two broad types of assessment, classroom-based and systemic assessment. We argue that the process of assessment informed by Rasch measurement theory (RMT) can potentially support the demands of both classroom-based and systemic assessment, particularly if a developmental approach to learning is adopted, and an underlying model of developing mathematical proficiency is explicit in the assessment instruments and their supporting material. An example of a mathematics instrument and its analysis which illustrates this approach, is presented. We note that the role of assessment in the 21st century is potentially powerful. This influential role can only be justified if the assessments are of high quality and can be selected to match suitable moments in learning progress and the teaching process. Users of assessment data must have sufficient knowledge and insight to interpret the resulting numbers validly, and have sufficient discernment to make considered educational inferences from the data for teaching and learning responses

Moran Eigenvector Filtering of Multi-year Yield Data with Application to Zone Development

A time‐series of yield monitor data may be used to identify field areas of consistently low or high yield to serve as productivity zones for site‐specific crop management. However, transient factors that affect yield in 1 yr, but not every year, detract from this approach. The objective of this study was to illustrate Moran eigenvector spatial filtering (MESF) with results from analysis of multi‐year crop yield data from two farm fields in the United States. The MESF method accounts for temporal autocorrelation within a common factor map representing the correlation across years and partitions stochastic geographic variation into spatially structured and unstructured components. Crop rotation data were utilized from a dryland field in east‐central South Dakota and an irrigated field in southwestern Georgia. A random effects (RE) model was estimated that utilized eigenfunctions of a geographic connectivity matrix to account for spatially structured random effects (SSRE) and unstructured random effects (SURE) in standardized z scores of multi‐year crop yield. The MESF method was evaluated with conventional averaging of unfiltered yield data as a reference for comparison. In South Dakota, the SSRE accounted for 26% of the yield variance shared across years. Distinct patterns appeared to be related to changes in soil type and landscape position. The Georgia field yielded similar results. The MESF is effective for revealing structured variation in a time series of yield monitor data and may be useful for defining productivity zones within fields

Managing and monitoring equality and diversity in UK sport: An evaluation of the sporting equals Racial Equality Standard and its impact on organizational change

Despite greater attention to racial equality in sport in recent years, the progress of national sports organizations toward creating equality of outcomes has been limited in the United Kingdom. The collaboration of the national sports agencies, equity organizations and national sports organizations (including national governing bodies of sport) has focused on Equality Standards. The authors revisit an earlier impact study of the Racial Equality Standard in sport and supplement it with another round of interview material to assess changing strategies to manage diversity in British sport. In particular, it tracks the impact on organizational commitment to diversity through the period of the establishment of the Racial Equality Standard and its replacement by an Equality Standard that deals with other diversity issues alongside race and ethnicity. As a result, the authors question whether the new, generic Equality Standard is capable of addressing racial diversity and promoting equality of outcomes. © 2006 Sage Publications

Physics-based modelling and simulation of reverberating reflections in ultrasonic guided wave inspections applied to welded rail tracks

The development of ultrasonic guided wave monitoring systems has become increasingly important as they have demonstrated the ability to detect damage in structures. An example of such a system is the Ultrasonic Broken Rail Detection system which uses pitch-catch piezoelectric transducers permanently attached to the rail to excite and receive ultrasonic guided wave signals. Changes in signals can provide a reliable indication of damage growth in the rail and ultimately reduce broken rails and derailments. However, the challenge during system development is obtaining monitoring data containing damage signatures as damaged sections of rail are immediately replaced when detected. Laboratory damage experiments are also not plausible due to end reflections from short rail sections dominating the response. Modelling and simulation thus become increasingly important to enable the simulation of unavailable damage scenarios for the upgradation of existing (or development of new reliable) guided wave-based monitoring systems. Two numerical procedures to model and simulate guided wave inspections encompassing the excitation, propagation and scattering from discontinuities in 1D waveguides are presented and applied to the inspection of the web of a welded rail. The major contribution highlighted by these procedures is the ability to simulate complex back and forth reverberating reflections. These reflections occur between various reflectors such as welds and other discontinuities such as damage. The two methods are different but complementary. The first one, which is based on a simple manual simulation of finite reverberating reflections, is useful for interpreting the results to understand how different reflections interact, especially where they overlap. The second method accounts for the scattering by all defects or discontinuities arbitrarily positioned in the waveguide. It offers a more accurate approximation of the simulated inspection since it accounts for infinite reflections. The simulation results obtained from the two modelling procedures are validated using a field experiment from a damage-free rail containing welds and holes as discontinuities. The results show that it would be possible to simulate inspections for unavailable damage scenarios. The paper is concluded with a thorough analysis of the inspection measurement using the first method.http://www.elsevier.com/locate/jsvihj2022Mechanical and Aeronautical Engineerin

Towards a new privacy: Totalitarianism, emotion and management discourse

This article reviews some leadership and management literature dealing with emotional demands in professional contexts. An image of the ‘real self’, requiring emotional privacy, is highly valued by individuals subjected to intense emotional demands. It is argued that the ‘real self’ and emotional privacy ought to be defended against emotional ‘totalitarianism’ at work in high performance education contexts. The writings of George Orwell are employed both to develop an understanding of totalitarianism and consider how it can be resisted. Orwell prized the ideal of the ‘real self’, and it is argued that recent management literature does not give sufficient consideration to understanding and protecting ‘private’ emotions. It is argued that management discourse, demanding increasing levels of ‘emotional labour’, might be working from an imperfect or incomplete understanding of emotional experience as it is actually lived. An analysis of an article from The Academy of Management Review exemplifies managerial preoccupation with emotional effectiveness, without considering how such effectiveness connects with other life contexts. Ideas taken from Orwell are proposed to develop and fortify an ideal of emotional privacy, making explicit links between emotions and the society in which emotions are nurtured and understood

Using the theory of planned behaviour as a process evaluation tool in randomised trials of knowledge translation strategies : A case study from UK primary care

Peer reviewedPublisher PD

Impact of COVID-19 response on global surgical volumes:an ongoing observational study

Objective: To determine whether location-linked anaesthesiology calculator mobile application (app) data can serve as a qualitative proxy for global surgical case volumes and therefore monitor the impact of the coronavirus disease 2019 (COVID-19) pandemic. Methods: We collected data provided by users of the mobile app "Anesthesiologist" during 1 October 2018-30 June 2020. We analysed these using RStudio and generated 7-day moving-average app use plots. We calculated country-level reductions in app use as a percentage of baseline. We obtained data on COVID-19 case counts from the European Centre for Disease Prevention and Control. We plotted changing app use and COVID-19 case counts for several countries and regions. Findings: A total of 100 099 app users within 214 countries and territories provided data. We observed that app use was reduced during holidays, weekends and at night, correlating with expected fluctuations in surgical volume. We observed that the onset of the pandemic prompted substantial reductions in app use. We noted strong cross-correlation between COVID-19 case count and reductions in app use in low- and middle-income countries, but not in high-income countries. Of the 112 countries and territories with non-zero app use during baseline and during the pandemic, we calculated a median reduction in app use to 73.6% of baseline. Conclusion: App data provide a proxy for surgical case volumes, and can therefore be used as a real-time monitor of the impact of COVID-19 on surgical capacity. We have created a dashboard for ongoing visualization of these data, allowing policy-makers to direct resources to areas of greatest need

Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity

Macrophages from C57BL/6J (B6) mice restrict growth of the intracellular bacterial pathogen Legionella pneumophila. Restriction of bacterial growth requires caspase-1 and the leucine-rich repeat-containing protein Naip5 (Birc1e). We identified mutants of L. pneumophila that evade macrophage innate immunity. All mutants were deficient in expression of flagellin, the primary flagellar subunit, and failed to induce caspase-1-mediated macrophage death. Interestingly, a previously isolated flagellar mutant (fliI) that expresses, but does not assemble, flagellin did not replicate in macrophages, and induced macrophage death. Thus, flagellin itself, not flagella or motility, is required to initiate macrophage innate immunity. Immunity to Legionella did not require MyD88, an essential adaptor for toll-like receptor 5 (TLR5) signaling. Moreover, flagellin of Legionella and Salmonella induced cytotoxicity when delivered to the macrophage cytosol using Escherichia coli as a heterologous host. It thus appears that macrophages sense cytosolic flagellin via a TLR5-independent pathway that leads to rapid caspase-1-dependent cell death and provides defense against intracellular bacterial pathogens