Categorizing stroke prognosis using different stroke scales

<p><b>Background and Purpose</b>: Stroke severity and dependency are often categorized to allow stratification for randomization or analysis. However, there is uncertainty whether the categorizations used for different stroke scales are equivalent. We investigated the amount of information retained by categorizing severity and dependency, and whether the currently used cut-offs are equivalent across different stroke scales.</p> <p><b>Methods</b>: Stroke severity and dependency have been categorized as mild, moderate, or severe. We studied 2 acute stroke unit cohorts, measuring Scandinavian Stroke Scale (SSS), modified Rankin Scale (mRS), Barthel Index (BI), and modified National Institutes of Health Stroke Scale (mNIHSS). Receiver operating characteristic (ROC) curves were examined to determine the ability of full and categorized scales to predict death and dependency. A weighted kappa analysis assessed agreement between the categorized scales.</p> <p><b>Results</b>: When scales are categorized, the area under the ROC curve is significantly reduced; however, the differences are small and may not be practically important. BI, mRS, and SSS all have excellent agreement with each other when categorized, whereas mNIHSS has substantial agreement with mRS and BI.</p> <p><b>Conclusions</b>: Little predictive information is lost when stroke scales are categorized. There is substantial to almost perfect agreement among categorized scales. Therefore the use and categorization of a variety of stroke severity or dependency scales is acceptable in analyses.</p&gt

Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells

Bovine papillomavirus (BPV) types 1 and 2 play an important role in the pathogenesis of equine sarcoids (ES), the most common cutaneous tumour affecting horses. MicroRNAs (miRNAs), small non-coding RNAs that regulate essential biological and cellular processes, have been found dysregulated in a wide range of tumours. The aim of this study was to identify miRNAs associated with ES. Differential expression of miRNAs was assessed in control equine fibroblasts (EqPalFs) and EqPalFs transformed with the BPV-1 genome (S6-2 cells). Using a commercially available miRNA microarray, 492 mature miRNAs were interrogated. In total, 206 mature miRNAs were differentially expressed in EqPalFs compared with S6-2 cells. Aberrant expression of these miRNAs in S6-2 cells can be attributed to the presence of BPV-1 genomes. Furthermore, we confirm the presence of 124 miRNAs previously computationally predicted in the horse. Our data supports the involvement of miRNAs in the pathogenesis of ES

Tabulation and summary of thermodynamic effects data for developed cavitation on ogive-nosed bodies

Thermodynamic effects data for developed cavitation on zero and quarter caliber ogives in Freon 113 and water are tabulated and summarized. These data include temperature depression (delta T), flow coefficient (C sub Q), and various geometrical characteristics of the cavity. For the delta T tests, the free-stream temperature varied from 35 C to 95 C in Freon 113 and from 60 C to 125 C in water for a velocity range of 19.5 m/sec to 36.6 m/sec. Two correlations of the delta T data by the entrainment method are presented. These correlations involve different combinations of the Nusselt, Reynolds, Froude, Weber, and Peclet numbers and dimensionless cavity length

Correlations by the entrainment theory of thermodynamic effects for developed cavitation in venturis and comparisons with ogive data

A semi-empirical entrainment theory was employed to correlate the measured temperature depression, Delta T, in a developed cavity for a venturi. This theory correlates Delta t in terms of the dimensionless numbers of Nusselt, Reynolds, Froude, Weber and Peclet, and dimensionless cavity length, L/D. These correlations are then compared with similar correlations for zero and quarter caliber ogives. In addition, cavitation number data for both limited and developed cavitation in venturis are presented

Comparison of 3-D viscous flow computations of Mach 5 inlet with experimental data

A time marching 3-D full Navier-Stokes code, called PARC3D, is validated for an experimental Mach 5 inlet configuration using the data obtained in the 10 x 10 ft supersonic wind tunnel at the NASA Lewis Research Center. For the first time, a solution is obtained for this configuration with the actual geometry, the tunnel conditions, and all the bleed zones modeled in the computation. Pitot pressure profiles and static pressures at various locations in the inlet are compared with the corresponding experimental data. The effect of bleed zones, located in different places on the inlet walls, in eliminating the low energy vortical flow generated from the 3-D shock-boundary layer interaction is simulated very well even though some approximations are used in applying the bleed boundary conditions and in the turbulence model. A further detailed study of the effect of individual bleed ports is needed to understand fully the actual mechanism of efficiently eliminating the vortical flow from the inlet. A better turbulence model would help to improve the accuracy even further in predicting the corner flow boundary layer profiles

Development of satisfactory lateral- directional handling qualities in the landing approach

Developing lateral stability and directional control handling qualities in landing approach control of aircraf

Lake, Land, and Sky: A Design Proposal for Northerly Island, Chicago

Shortly before midnight on March 30th 2003, without notice and at the orders of Mayor Richard M. Daley, bulldozers destroyed a small airport known as Meigs Field on Chicago\u27s Northerly Island. Planes were trapped on the ground and other flights diverted. This action, dramatic and of debatable legality, effectively ended the struggle between the Mayor\u27s office who wanted the site for a park, and the state legislature who wanted to keep the airport open (in no small part for their own ease of commuting). With the airport now demolished, Chicago has turned its attention to developing a vision for the future of Northerly Island. The island is, in fact, a ninety-one acre peninsula jutting into Lake Michigan from Chicago\u27s downtown. Envisioned as a public park and constructed in the 1920s, it is the only lakefront structure in Daniel Burnham\u27s famous 1909 Chicago Plan that was actually built (four other proposed islands were never created). The Adler Planetarium, now a National Historic Landmark, was built at the northern end of the island in 1930. It was the first planetarium to be built in the Western hemisphere and is the oldest planetarium in existence today. In 1933 Northerly Island was the location for Chicago\u27s second world fair and in 1947, now connected to the mainland by a causeway (a 1936 WPA project) that replaced the original bridge and having lost a bid to become the home of the United Nations, Northerly Island became the site of Meigs Field airport. Although some public facilities such as the 12th St beach and the planetarium continued to operate, the central idea of Burnham\u27s plan, that of a large public park, was lost