The formation of oriented barium carbonate from the decomposition of yttria-doped barium zirconate films

Yttria doped barium zirconate (BZY) thin films show promise thanks to their high proton conductivities and their possibility for use in studying fundamental processes such as exsolution. This work demonstrates that highly oriented BZY thin (45 nm) films on (100) single crystal strontium titanate decompose into oriented barium carbonate rods and yttria stabilized zirconia when exposed to industrial grade Ar or pure CO at 800 °C. It is shown with transmission electron microscopy that the rods nucleate on the BZY surface. The causes and modes of decomposition in these thin films are discussed in detail

A Web-Based Application to Simulate Manual Bag-Valve-Tube Ventilation

What’s the Problem? The COVID-19 pandemic has threatened ventilator capacity in many locations which has led to alternative solutions to meet surge ventilator capacity including a strategy for deploying large-scale volunteer continuous bag-valve-tube (BVT) ventilation While an online training module may teach the manual ventilation volunteer force requisite knowledge, evidence suggests technology enhanced simulation training in health professions training is associated with improved outcomes for desired knowledge, skills and behavior

Ultra-Fast High Temperature Sintering (UHS) of Strontium Titanate

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Aptamer-based multiplexed proteomic technology for biomarker discovery

Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 [mu]L of serum or plasma). Our current assay allows us to measure ~800 proteins with very low limits of detection (1 pM average), 7 logs of overall dynamic range, and 5% average coefficient of variation. This technology is enabled by a new generation of aptamers that contain chemically modified nucleotides, which greatly expand the physicochemical diversity of the large randomized nucleic acid libraries from which the aptamers are selected. Proteins in complex matrices such as plasma are measured with a process that transforms a signature of protein concentrations into a corresponding DNA aptamer concentration signature, which is then quantified with a DNA microarray. In essence, our assay takes advantage of the dual nature of aptamers as both folded binding entities with defined shapes and unique sequences recognizable by specific hybridization probes. To demonstrate the utility of our proteomics biomarker discovery technology, we applied it to a clinical study of chronic kidney disease (CKD). We identified two well known CKD biomarkers as well as an additional 58 potential CKD biomarkers. These results demonstrate the potential utility of our technology to discover unique protein signatures characteristic of various disease states. More generally, we describe a versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations. This unbiased and highly multiplexed search engine will enable the discovery of novel biomarkers in a manner that is unencumbered by our incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

A Study of Road Autonomous Delivery Robots and Their Potential Impacts on Freight Efficiency and Travel

Road autonomous mobile robots have attracted the attention of delivery companies and policy makers for their potential to reduce costs and increase urban freight efficiency. Established delivery companies and new startups are investing in technologies that reduce delivery times and/or increase delivery drivers’ productivity. In this context, the adoption of Road Automatic (or Autonomous) Delivery Robots (RADRs) has a growing appeal. Several RADRs are currently being tested in the United States. The key novel contributions of this research are: (a) an analysis of the characteristics and regulation of RADRs in the US and (b) a study of the relative travel, time, and cost efficiencies that RADRs can bring about when compared to traditional van deliveries. The results show that RADRs can provide substantial cost savings in many scenarios but in all cases, at the expense of substantially higher vehicle miles per customer served. Unlike sidewalk autonomous delivery robots (SADRs), it is possible the RADRs will contribute significantly to additional vehicle miles per customer served

A Study of Sidewalk Autonomous Delivery Robots and Their Potential Impacts on Freight Efficiency and Travel

E-Commerce and package deliveries are growing at a fast pace and there is an increased demand for same-day deliveries. Established delivery companies and new startups are investing in technologies that reduce delivery times and/or increase delivery drivers’ productivity. In this context, the adoption of Sidewalk Automated (or Autonomous) Delivery Robots (SADRs) has a growing appeal. SADRs are pedestrian sized robots that deliver items to customers without the intervention of a delivery person. Since SADRs travel on sidewalks they have been the subject of increasing regulation by local agencies in the US. The three research questions that guide this research effort are: (a) What are the limitations imposed by existing regulations in the US, (b) What are the technical capabilities of existing SADRs, and (c) Given the existing capabilities and regulations, what are the time/cost savings and efficiencies that SADRs can bring about? The first part of the research discusses current US regulations on SADRs and reviews existing SADR devices and their capabilities. Building on this knowledge, the second half of the research presents a novel model to estimate delivery time and number of customers served utilizing a combination of SADRs and a special delivery van. These results are compared with a baseline (or prevailing) delivery system utilizing only a conventional delivery van-human driver. Results, insights, and potential implications are discussed. The results show that SADRs can provide substantial cost and time savings in some scenarios. Furthermore, the introduction of SADRs may significantly reduce on road travel per package delivered

A Study of the Competitiveness of Autonomous Delivery Vehicles in Urban Areas

The rapid growth of e-commerce and package deliveries across the globe is demanding new solutions to meet customers’ desire for more and faster deliveries. This research focuses on the cost competitiveness of autonomous air and ground delivery vehicles. Three types of autonomous vehicle are analyzed: drones, sidewalk autonomous delivery robots (SADRs), and road autonomous delivery robots (RADRs). Autonomous vehicles are compared against a typical delivery van. The impact of capacity, range and time constraints are analyzed. Results show that each type of autonomous delivery vehicle is suitable in different scenarios and can therefore complement each other to reduce costs or on road distance traveled