282,972 research outputs found

    The Saikewicz Decision and Patient Autonomy

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    Floquet engineering from long-range to short-range interactions

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    Quantum simulators based on atoms or molecules often have long-range interactions due to dipolar or Coulomb interactions. We present a method based on Floquet engineering to turn a long-range interaction into a short-range one. By modulating a magnetic-field gradient with one or a few frequencies, one reshapes the interaction profile, such that the system behaves as if it only had nearest-neighbor interactions. Our approach works in both one and two dimensions and for both spin-1/2 and spin-1 systems. It does not require individual addressing, and is applicable to all experimental systems with long-range interactions: trapped ions, polar molecules, Rydberg atoms, nitrogen-vacancy centers, and cavity QED. Our approach allows one achieve a short-range interaction without relying on Hubbard superexchange.Comment: 6 pages, 5 figure

    Reaction of N,N-Dimethyltryptamine with Dichloromethane Under Common Experimental Conditions.

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    A large number of clinically used drugs and experimental pharmaceuticals possess the N,N-dimethyltryptamine (DMT) structural core. Previous reports have described the reaction of this motif with dichloromethane (DCM), a common laboratory solvent used during extraction and purification, leading to the formation of an undesired quaternary ammonium salt byproduct. However, the kinetics of this reaction under various conditions have not been thoroughly described. Here, we report a series of experiments designed to simulate the exposure of DMT to DCM that would take place during extraction from plant material, biphasic aqueous work-up, or column chromatography purification. We find that the quaternary ammonium salt byproduct forms at an exceedingly slow rate, only accumulates to a significant extent upon prolonged exposure of DMT to DCM, and is readily extracted into water. Our results suggest that DMT can be exposed to DCM under conditions where contact times are limited (<30 min) with minimal risk of degradation and that this byproduct is not observed following aqueous extraction. However, alternative solvents should be considered when the experimental conditions require longer contact times. Our work has important implications for preparing a wide-range of pharmaceuticals bearing the DMT structural motif in high yields and purities

    Sub-committee Approval Voting and Generalised Justified Representation Axioms

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    Social choice is replete with various settings including single-winner voting, multi-winner voting, probabilistic voting, multiple referenda, and public decision making. We study a general model of social choice called Sub-Committee Voting (SCV) that simultaneously generalizes these settings. We then focus on sub-committee voting with approvals and propose extensions of the justified representation axioms that have been considered for proportional representation in approval-based committee voting. We study the properties and relations of these axioms. For each of the axioms, we analyse whether a representative committee exists and also examine the complexity of computing and verifying such a committee
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