3,423 research outputs found
The hot gas content of fossil galaxy clusters
We investigate the properties of the hot gas in four fossil galaxy systems
detected at high significance in the Planck Sunyaev-Zeldovich (SZ) survey.
XMM-Newton observations reveal overall temperatures of kT ~ 5-6 keV and yield
hydrostatic masses M500,HE > 3.5 x 10e14 Msun, confirming their nature as bona
fide massive clusters. We measure the thermodynamic properties of the hot gas
in X-rays (out to beyond R500 in three cases) and derive their individual
pressure profiles out to R ~ 2.5 R500 with the SZ data. We combine the X-ray
and SZ data to measure hydrostatic mass profiles and to examine the hot gas
content and its radial distribution. The average Navarro-Frenk-White (NFW)
concentration parameter, c500 = 3.2 +/- 0.4, is the same as that of relaxed
`normal' clusters. The gas mass fraction profiles exhibit striking variation in
the inner regions, but converge to approximately the cosmic baryon fraction
(corrected for depletion) at R500. Beyond R500 the gas mass fraction profiles
again diverge, which we interpret as being due to a difference in gas clumping
and/or a breakdown of hydrostatic equilibrium in the external regions. Overall
our observations point to considerable radial variation in the hot gas content
and in the gas clumping and/or hydrostatic equilibrium properties in these
fossil clusters, at odds with the interpretation of their being old, evolved
and undisturbed. At least some fossil objects appear to be dynamically young.Comment: 4 pages, 2 figures. Accepted for publication in A&
Spatial Multiplexing of QPSK Signals with a Single Radio: Antenna Design and Over-the-Air Experiments
The paper describes the implementation and performance analysis of the first
fully-operational beam-space MIMO antenna for the spatial multiplexing of two
QPSK streams. The antenna is composed of a planar three-port radiator with two
varactor diodes terminating the passive ports. Pattern reconfiguration is used
to encode the MIMO information onto orthogonal virtual basis patterns in the
far-field. A measurement campaign was conducted to compare the performance of
the beam-space MIMO system with a conventional 2-by-?2 MIMO system under
realistic propagation conditions. Propagation measurements were conducted for
both systems and the mutual information and symbol error rates were estimated
from Monte-Carlo simulations over the measured channel matrices. The results
show the beam-space MIMO system and the conventional MIMO system exhibit
similar finite-constellation capacity and error performance in NLOS scenarios
when there is sufficient scattering in the channel. In comparison, in LOS
channels, the capacity performance is observed to depend on the relative
polarization of the receiving antennas.Comment: 31 pages, 23 figure
The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates
Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very similar to idiopathic Parkinson's disease by selectively destroying dopaminergic nigrostriatal neurons. This gives rise to the hypothesis that Parkinson's disease may be caused by endogenous or environmental toxins. Endogenous excitatory amino acids (EAAs) such as L-glutamate could be involved in neurodegenerative disorders including Parkinson's disease. We report in this study that the competitive NMDA antagonist CPP (3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid) protects nigral tyrosine hydroxylase (TH) positive neurons from degeneration induced by systemic treatment with MPTP in common marmosets. This indicates that EAAs are involved in the pathophysiological cascade of MPTP-induced neuronal cell death and that EAA antagonists may offer a neuroprotective therapy for Parkinson's disease
Asymptotic Conformal Yano--Killing Tensors for Schwarzschild Metric
The asymptotic conformal Yano--Killing tensor proposed in J. Jezierski, On
the relation between metric and spin-2 formulation of linearized Einstein
theory [GRG, in print (1994)] is analyzed for Schwarzschild metric and tensor
equations defining this object are given. The result shows that the
Schwarzschild metric (and other metrics which are asymptotically
``Schwarzschildean'' up to O(1/r^2) at spatial infinity) is among the metrics
fullfilling stronger asymptotic conditions and supertranslations ambiguities
disappear. It is also clear from the result that 14 asymptotic gravitational
charges are well defined on the ``Schwarzschildean'' background.Comment: 8 pages, latex, no figure
Asymmetric nanofluidic grating detector for differential refractive index measurement and biosensing.
Measuring small changes in refractive index can provide both sensitive and contactless information on molecule concentration or process conditions for a wide range of applications. However, refractive index measurements are easily perturbed by non-specific background signals, such as temperature changes or non-specific binding. Here, we present an optofluidic device for measuring refractive index with direct background subtraction within a single measurement. The device is comprised of two interdigitated arrays of nanofluidic channels designed to form an optical grating. Optical path differences between the two sets of channels can be measured directly via an intensity ratio within the diffraction pattern that forms when the grating is illuminated by a collimated laser beam. Our results show that no calibration or biasing is required if the unit cell of the grating is designed with an appropriate built-in asymmetry. In proof-of-concept experiments we attained a noise level equivalent to âŒ10(-5) refractive index units (30 Hz sampling rate, 4 min measurement interval). Furthermore, we show that the accumulation of biomolecules on the surface of the nanochannels can be measured in real-time. Because of its simplicity and robustness, we expect that this inherently differential measurement concept will find many applications in ultra-low volume analytical systems, biosensors, and portable devices
In situ microfluidic cryofixation for cryo Focused Ion Beam milling and cryo electron tomography.
We present a microfluidic platform for studying structure-function relationships at the cellular level by connecting video rate live cell imaging with in situ microfluidic cryofixation and cryo-electron tomography of near natively preserved, unstained specimens. Correlative light and electron microscopy (CLEM) has been limited by the time required to transfer live cells from the light microscope to dedicated cryofixation instruments, such as a plunge freezer or high-pressure freezer. We recently demonstrated a microfluidic based approach that enables sample cryofixation directly in the light microscope with millisecond time resolution, a speed improvement of up to three orders of magnitude. Here we show that this cryofixation method can be combined with cryo-electron tomography (cryo-ET) by using Focused Ion Beam milling at cryogenic temperatures (cryo-FIB) to prepare frozen hydrated electron transparent sections. To make cryo-FIB sectioning of rapidly frozen microfluidic channels achievable, we developed a sacrificial layer technique to fabricate microfluidic devices with a PDMS bottom wall <5â”m thick. We demonstrate the complete workflow by rapidly cryo-freezing Caenorhabditis elegans roundworms L1 larvae during live imaging in the light microscope, followed by cryo-FIB milling and lift out to produce thin, electron transparent sections for cryo-ET imaging. Cryo-ET analysis of initial results show that the structural preservation of the cryofixed C. elegans was suitable for high resolution cryo-ET work. The combination of cryofixation during live imaging enabled by microfluidic cryofixation with the molecular resolution capabilities of cryo-ET offers an exciting avenue to further advance space-time correlative light and electron microscopy (st-CLEM) for investigation of biological processes at high resolution in four dimensions
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