Abordaxe fisioterápico no asma infantil

[Resumen] Objetivo: analizar qué intervenciones se están llevando a cabo por parte de la fisioterapia en la patología del asma. Material y métodos: revisión de artículos en los cuales se lleven a cabo intervenciones de fisioterapia en niños asmáticos. La búsqueda se efectuó en las bases de datos Pubmed, PEDro, Web of Science y Scopus, seleccionando artículos publicados entre 2013 y 2017 en lengua inglesa, portuguesa y española. Resultados: se seleccionaron 6 artículos, la mayoría de calidad intermedia, con variabilidad en el número de sujetos en cada estudio. La población que se seleccionó comprende desde el nacimiento hasta los 18 años. Las terapias fisioterápicas empleadas son variables. Se realiza en todos los casos un tratamiento enfocado al abordaje de las capacidades físicas por medio de diferentes programas de entrenamiento que cada estudio enfocó de forma diferente. Los aspectos más evaluados han sido la función pulmonar, la calidad de vida y la disnea, medidos a través de diferentes test y pruebas funcionales. Se obtienen resultados positivos en el manejo del asma con cada uno de estos programas de entrenamiento físico. Conclusiones: existen múltiples programas de intervención fisioterápica sobre el asma. Se llevan a cabo programas de entrenamiento de la musculatura inspiratoria, entrenamiento aeróbico, anaeróbico, de fuerza y equilibrio por parte de la fisioterapia en el abordaje de esta patología y todos presentan beneficio sobre ella. Asimismo, se objetivó que el programa de tratamiento que engloba un entrenamiento basado en ejercicio aeróbico y ejercicios respiratorios presenta una mayor eficacia.[Abstract] Objective: to analyze what interventions are being carried out by physiotherapy in the pathology of asthma. Material and methods: review of articles in which physiotherapy interventions are carried out in asthmatic children. The search was carried out in the Pubmed, PEDro, Web of Science and Scopus databases, selecting articles published between 2013 and 2017 in English, Portuguese and Spanish. Results: Six articles were selected, most of intermediate quality, with variability in the number of subjects in each study. The population that was selected comprises from birth to 18 years. The physiotherapeutic therapies used are variable. In all cases, a treatment focused on addressing physical abilities is carried out through different training programs that each study focused on differently. The most evaluated aspects have been pulmonary function, quality of life and dyspnea, measured through different tests and functional tests. Positive results are obtained in the management of asthma with each of these physical training programs. Conclusions: There are multiple programs of physiotherapy intervention on asthma. Training programs for inspiratory musculature, aerobic, anaerobic, strength and balance training are carried out by physiotherapy in the approach to this pathology and all have benefit over it. Likewise, it was found that the treatment program that includes a training based on aerobic exercise and breathing exercises is more effective.[Resumo] Obxectivo: analizar que intervencións se están a facer por parte da fisioterapia na patoloxía da asma. Material e metodoloxía: revisión de artículos nos que se fagan intervencións de fisioterapia en nenos asmáticos. A búsqueda efectuouse nas bases de datos Pubmed, PEDro, Web of Science y Scopus, seleccionando artículos publicados entre 2013 y 2017 en lingua inglesa, portuguesa e española. Resultados: seleccionáronse 6 artigos, a maioría de calidade intermedia, con variabilidade no número de suxeitos en cada estudo. A poboación que se seleccionou comprende dende o nacemento ata os 18 anos. As terapias fisioterápicas empregadas son variables. Realizouse en todos os casos un tratamento enfocado á abordaxe das capacidades físicas por medio de diferentes programas de entrenamento que cada estudo enfocou de forma diferente. Os aspectos máis avaliados foron a función pulmonar, a calidade da vida e a disnea, medidos a través de diferentes test e probas funcionais. Obtéñense resultados positivos no manexo do asma con cada un destes programas de entrenamento físico. Conclusións: existen múltiples programas de intervención fisioterápica sobre a asma infantil. Lévanse a cabo programas de entrenamento da musculatura inspiratoria, entrenamiento aeróbico, anaeróbico, de forza e equilibrio por parte da fisioterapia no abordaxe desta patoloxía e todos presentan beneficio sobre ela. Así mesmo obxectivouse que o programa de tratamento que engloba un entrenamento baseado no exercicio aeróbico e exercicios respiratorios presenta unha maior eficacia.Traballo fin de grao (UDC.FCS). Fisioterapia. Curso 2017/201

The Grizzly, February 28, 1995

Core Changes Proposed: Public Speaking, ESS 100, and Fine Arts in Question • Delta Pi Suspended • Ursinus Prepares for Spring Service Day • Letter from Dean Kane • Airband • S.T.A.R. to Sponsor Sexual Assault Awareness Week • The Sculpture Population Boom • Spirit, Black and Female Celebrates Black History Month • How We Pick Our Entertainers • Letters to the Editor • Humiliation • Luka is ECAC Gymnast of the Week • Cauley Seeded 14th at Nationals • Ortman is Going to Nationals • Bears Open Up in Cocoa on Saturday • Caggiano, Laidlaw, and Widmaier Win Indoor Track Titles • Cosgrove Named Centennial Player of the Year • Ursinus Wins First-Ever Women\u27s Hoop Titlehttps://digitalcommons.ursinus.edu/grizzlynews/1355/thumbnail.jp

The Grizzly, January 31, 1995

Hangin\u27 with Mickey! • New Rules for Guys\u27 Pledging • New Faces in Ursinus Security • Chechens Fortify Grozny • O.J. Trial Facing Delays • Kennedy Family Matriarch Dies • Senior Spotlight: Ellen Cosgrove • Baseball Blows • Response to State of the Union • Letter to the Editor • Echoes of an Artist • Ursinus Brought Back to Earth • Ursinus Splits with F&M • Ursinus Women Set School Record at Freedom Classic • Bears Lose Heartbreaker at Muhlenberg • Bears Win Key Conference Matchhttps://digitalcommons.ursinus.edu/grizzlynews/1351/thumbnail.jp

The Grizzly, November 16, 1993

A Message From the Class of \u2797: The Freshmen Finally Surface • The Crunch is On • Fundraiser to Benefit Cancer Patients • Whitman Denies Allegations • Does Date Rape Exist at Ursinus? • ProTheatre to Present Henry Play • Freeze Tag and Organ Music? • Date Auction / Lease / Rental • Silenced by Shame • In Defense of Greek Life, Part Two • Anesthetizing of Literature • Bears Finish Stronghttps://digitalcommons.ursinus.edu/grizzlynews/1325/thumbnail.jp

The Grizzly, March 21, 1995

Ursinus and PV District Announce Partnership • Cross-dressers, Polka Dancers, and the Jackson Five: Airband \u2795 Raises Over $2400 • No Ruby for Class of \u2796? • Spotlight on Dr. Hemphill • Fatal Talk Shows: Jenny Jones Show Provokes Homicide • Choral Ensemble Presents Annual Concert • Housing for Everyone • Student Spotlight: Kristen Baldini • Portrait of Venezuela • Experiencing proTheatre at U.C.! • Searching for a Topic • Letters to the Editor: It\u27s a Matter of Time; What Happened to B.Y.O.? • Princeton Concert Jazz Ensemble to Perform • Gilot Speaks About Paintings • ProTheatre to Perform Our Country\u27s Good • Baseball Finds Fun in the Sun • Sammartino Powers Softball Team on Southern Trip • Lax Team Routs Widener • Cosgrove Named Second-Team All American • Men\u27s Tennis Off to Tough Start • Courtney 11th on Beam • Cauley 18th at Swimming Championships • Ursinus Falls to Hopkins 77-67 in NCAA\u27shttps://digitalcommons.ursinus.edu/grizzlynews/1356/thumbnail.jp

Somatic mutations in salivary duct carcinoma and potential therapeutic targets

Background: Salivary duct carcinomas (SDCa) are rare highly aggressive malignancies. Most patients die from distant metastatic disease within three years of diagnosis. There are limited therapeutic options for disseminated disease. Results: 11 cases showed androgen receptor expression and 6 cases showed HER2 amplification. 6 Somatic mutations with additional available targeted therapies were identified: EGFR (p. G721A: Gefitinib), PDGFRA (p. H845Y: Imatinib and Crenolanib), PIK3CA (p. H1047R: Everolimus), ERBB2 (p. V842I: Lapatinib), HRAS (p. Q61R: Selumetinib) and KIT (p. T670I: Sorafenib). Furthermore, alterations in PTEN, PIK3CA and HRAS that alter response to androgen deprivation therapy and HER2 inhibition were also seen. Materials and Methods: Somatic mutation analysis was performed on DNA extracted from 15 archival cases of SDCa using the targeted Illumina TruSeq Amplicon Cancer Panel. Potential targetable genetic alterations were identified using extensive literature and international somatic mutation database (COSMIC, KEGG) search. Immunohistochemistry for androgen receptor and immunohistochemistry and fluorescent in situ hybridization for HER2 were also performed. Conclusions: SDCa show multiple somatic mutations, some that are amenable to pharmacologic manipulation and others that confer resistance to treatments currently under investigation. These findings emphasize the need to develop testing and treatment strategies for SDCa. © Khoo et al

Evaluation of range of motion restriction within the hip joint

In Total Hip Arthroplasty, determining the impingement free range of motion requirement is a complex task. This is because in the native hip, motion is restricted by both impingement as well as soft tissue restraint. The aim of this study is to determine a range of motion benchmark which can identify motions which are at risk from impingement and those which are constrained due to soft tissue. Two experimental methodologies were used to determine motions which were limited by impingement and those motions which were limited by both impingement and soft tissue restraint. By comparing these two experimental results, motions which were limited by impingement were able to be separated from those motions which were limited by soft tissue restraint. The results show motions in extension as well as flexion combined with adduction are limited by soft tissue restraint. Motions in flexion, flexion combined with abduction and adduction are at risk from osseous impingement. Consequently, these motions represent where the maximum likely damage will occur in femoroacetabular impingement or at most risk of prosthetic impingement in Total Hip Arthroplasty

Two Factor Reprogramming of Human Neural Stem Cells into Pluripotency

BACKGROUND:Reprogramming human somatic cells to pluripotency represents a valuable resource for the development of in vitro based models for human disease and holds tremendous potential for deriving patient-specific pluripotent stem cells. Recently, mouse neural stem cells (NSCs) have been shown capable of reprogramming into a pluripotent state by forced expression of Oct3/4 and Klf4; however it has been unknown whether this same strategy could apply to human NSCs, which would result in more relevant pluripotent stem cells for modeling human disease. METHODOLOGY AND PRINCIPAL FINDINGS:Here, we show that OCT3/4 and KLF4 are indeed sufficient to induce pluripotency from human NSCs within a two week time frame and are molecularly indistinguishable from human ES cells. Furthermore, human NSC-derived pluripotent stem cells can differentiate into all three germ lineages both in vitro and in vivo. CONCLUSIONS/SIGNIFICANCE:We propose that human NSCs represent an attractive source of cells for producing human iPS cells since they only require two factors, obviating the need for c-MYC, for induction into pluripotency. Thus, in vitro human disease models could be generated from iPS cells derived from human NSCs