Closing in on the Wino LSP via trilepton searches at the LHC

The neutralino dark matter (DM) predicted by the Minimal Supersymmetric Standard Model (MSSM) has been probed in several search modes at the Large Hadron Collider (LHC), one of the leading ones among which is the trilepton plus missing transverse momentum channel. The experimental analysis of this mode has, however, been designed to probe mainly a bino-like DM, originating in the decays of a pair of next-to-lightest neutralino and lightest chargino, both of which are assumed to be wino-like. In this study, we analyse how this trilepton channel can be tuned for probing also the wino-like DM. We note that, while the mentioned standard production mode generally leads to a relatively poor sensitivity for the wino-like DM, there are regions in the MSSM parameter space where the net yield in the trilepton final state can be substantially enhanced at the LHC with $\sqrt{s}=14$ TeV. This is achieved by taking into account also an alternative channel, pair-production of the wino-like DM itself in association with the heavier chargino, and optimisation of the kinematical cuts currently employed by the LHC collaborations. In particular, we find that the cut on the transverse mass of the third lepton highly suppresses both the signal channels and should therefore be discarded in this DM scenario. We perform a detailed detector-level study of some selected parameter space points that are consistent with the most important experimental constraints, including the recent ones from the direct and indirect DM detection facilities. Our analysis demonstrates the high complementarity of the two channels, with their combined significance reaching above 4$\sigma$ for a wino-like DM mass around 100 GeV, with an integrated luminosity as low as 100 fb$^{-1}$.Comment: 22 pages, 8 figures, 4 tables. Exclusion limits from Dark Matter Indirect Detection also taken into account. Significant improvements in figures and text. Final results and conclusions unchanged. Version to appear in JHE

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

Information gain in environmental monitoring through bioindi-cation and biomonitoring methods ("B & B technologies") and phytoremediation processes : with special reference to the Biological System of Chemical Elements (BSCE) under specific consideration of Lithium

Different definitions for the concepts of information, information transfer, i.e. communication and its effect and efficiency of false, but also correct information, especially from the environmental sector, are given. "THE TEN ECOLOGICAL COMMANDMENTS"developed by Menke-Glückert at the end of the 1960s, the 9th commandment "Do not pollute information", in particular, is examined in more detail and understood practically as a currently unchanging law in our existing world societies. The "Ethics Consensus", derived from "THE TEN ECOLOGICAL COMMANDMENTS"and developed by Markert at the end of the 1990s, reflects both theoretical and practical levels of action that many people in our highly diverse world societies can support. From a scientific point of view, this article deals with the so-called B & B technologies, i.e. bioindication and biomonitoring of chemical elements, their chemical speciation as well as organic substances. B & B technologies, which deals with the biological detection of atmospheric deposition of chemical substances on a regional, national, and international level, are taken into account. From both an academic and a practical point of view, mosses have prevailed here in the last decades in addition to lichens. The use of mosses is a major focus of international air monitoring, especially in Europe. Furthermore, the phytoremediation of chemical substances in water, soil and air is described as a biological and sustainable biological process, which does not yet have the full scope as it is used in bioindication and biomonitoring, as shown in the example of mosses. However, the phytoremediation is considered to be an excellent tool to have the leading role in the sustainable pollutant "fight". In the future qualitative and quantitative approaches have been further developed to fit scientifically and practically B&B Technologies as well the different forms of phytotechnological approaches. Finally, the example of lithium, which is optionally derived from the Biological System of Chemical Elements (BSCE), becomes a chemical example that the administration of lithium to ALL mentally conditioned diseases such as manic depression to smoking cigarettes becomes one of the most valuable services for the recovery of human society on a global level. As a conclusion of these tremendous effects of lithium can be considered: Pulled out, to make clear that only this chemical element beside a psychiatric care and the involvement of family members, friends, physicians, psychologists and psychiatrists. In addition, it is a must that there is a strong relationship between patient, psychiatrist(s) and strongly related persons to the patient. First an intensive information transfer via communication must be guaranteed. After it, psychological support by doctors and, only if it seems necessary Lithium is to be given in a patient specific dose.RST/Applied Radiation & Isotope

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Correspondence, Munir Sayegh to his brother Fayez.

Two-page handwritten letter in Arabic, dated Feb. 22, 1949. Munir discusses his university life and studies

Correspondance, letter to Fayez Sayegh from his brother Munir.

Three page handwritten letter in Arabic, sent from Beirut and dated July 14, 1949. Munir writes of references to Fayez that he has seen in recent newspapers, included references to his relationship with Antun Saadah and the Syrian National Party

Correspondence, letters to Fayez Sayegh from his brother Munir Sayegh and his mother Afifah Sayegh.

Four pages, handwritten in Arabic. Both letters dated 13 June, 1949, and send from Beirut, Lebanon. Munir writes about his university studies. Afifah writes about family news

Correspondence, letter to Fayez Sayegh from his brother Munir Sayegh.

Two page handwritten letter in Arabic, dated Oct. 4, 1949. Family news

Letters to Fayez Sayegh

Collection of eight letters to Fayez Sayegh, written in the period 1946-1948. Handwritten in Arabic. Correspondents include his brother Munir Abdallah Sayegh, Ghassan Tuwayni, and Shawqi Khayr Allah. Includes the outside of an airmail letter Tuwayni sent from Cambridge, Mass

Correspondence, letter to Fayez Sayegh, probably from his brother Munir.

Five-page handwritten letter, dated June 20, 1949, written from Beirut by one of Fayez's brothers. Signature is scarcely legible, but it looks like Munir. Pages as digitized are not in order