Internal stress wave measurements in solids subjected to lithotripter pulses

Semiconductor strain gauges were used to measure the internal strain along the axes of spherical and disk plaster specimens when subjected to lithotripter shock pulses. The pulses were produced by one of two lithotripters. The first source generates spherically diverging shock waves of peak pressure approximately 1 MPa at the surface of the specimen. For this source, the incident and first reflected pressure (P) waves in both sphere and disk specimens were identified. In addition, waves reflected by the disk circumference were found to contribute significantly to the strain fields along the disk axis. Experimental results compared favorably to a ray theory analysis of a spherically diverging shock wave striking either concretion. For the sphere, pressure contours for the incident P wave and caustic lines were determined theoretically for an incident spherical shock wave. These caustic lines indicate the location of the highest stresses within the sphere and therefore the areas where damage may occur. Results were also presented for a second source that uses an ellipsoidal reflector to generate a 30-MPa focused shock wave, more closely approximating the wave fields of a clinical extracorporeal lithotripter

An interferometric technique for B/A measurement

An isentropic phase method is described for measuringin vitro the acoustic nonlinearity parameterB/A of several aqueous buffers, protein solutions, lipid oils, and emulsions. The technique relies upon the use of an acoustic interferometer to measure the small changes in sound speed that accompany a rapid hydrostaticpressure change of between one and two atmospheres. Average accuracies of 0.85% are attainable with this method

Measurement of pressure and assessment of cavitation for a 22.5-kHz intra-arterial angioplasty device

This study was performed to understand better the mechanisms of action of an (22.5 kHz) ultrasonic wire catheter device used to remove atheromatous plaque in diseased blood vessels (ultrasonic angioplasty). During a clinical procedure, the wire acts as an acoustic waveguide to transfer acoustic energy from a generator outside the body to the ball tip of the wire, which is inserted in the blood vessel. The acoustic field radiated by the vibrating ball tip (1.5- to 3.0-mm diameter), was mapped in a relatively large (600 L) water tank and compared to the field from a well-characterized simple source. A dipolelike radiation pattern due to the translating ball tip was observed. At low power settings, standing wave effects in a smaller cylindrical volume (200-mm diameter, 350-mm height), which was used to simulate anthropometric dimensions, increase relative to the larger tank measurements. The standing wave ratio is dependent upon the pc characteristics of the medium and the dimensions of the volume, rather than on the absorption at this frequency. At high power-settings of the device, cavitation at the tip of the wire was measured using a 20-MHz passive cavitation detection scheme

Acoustical Society Of America Helmholtz-Rayleigh Interdisciplinary Silver Medal In Physical Acoustics, Biomedical Acoustics, And Engineering Acoustics: Armen Sarvazyan

The Silver Medal is presented to individuals, without age limitation, for contributions to the advancement of science, engineering, or human welfare through the application of acoustic principles, or through research accomplishment in acoustics

An exponential lower bound for Individualization-Refinement algorithms for Graph Isomorphism

The individualization-refinement paradigm provides a strong toolbox for testing isomorphism of two graphs and indeed, the currently fastest implementations of isomorphism solvers all follow this approach. While these solvers are fast in practice, from a theoretical point of view, no general lower bounds concerning the worst case complexity of these tools are known. In fact, it is an open question whether individualization-refinement algorithms can achieve upper bounds on the running time similar to the more theoretical techniques based on a group theoretic approach. In this work we give a negative answer to this question and construct a family of graphs on which algorithms based on the individualization-refinement paradigm require exponential time. Contrary to a previous construction of Miyazaki, that only applies to a specific implementation within the individualization-refinement framework, our construction is immune to changing the cell selector, or adding various heuristic invariants to the algorithm. Furthermore, our graphs also provide exponential lower bounds in the case when the $k$-dimensional Weisfeiler-Leman algorithm is used to replace the standard color refinement operator and the arguments even work when the entire automorphism group of the inputs is initially provided to the algorithm.Comment: 21 page

Engineering News, Fall 2019

https://scholarcommons.scu.edu/eng_news/1043/thumbnail.jp

Engineering News, Summer 2018

https://scholarcommons.scu.edu/eng_news/1042/thumbnail.jp

Microbubble Cavitation Imaging

Ultrasound cavitation of microbubble contrast agents has a potential for therapeutic applications such as sonothrombolysis (STL) in acute ischemic stroke. For safety, efficacy, and reproducibility of treatment, it is critical to evaluate the cavitation state (moderate oscillations, stable cavitation, and inertial cavitation) and activity level in and around a treatment area. Acoustic passive cavitation detectors (PCDs) have been used to this end but do not provide spatial information. This paper presents a prototype of a 2-D cavitation imager capable of producing images of the dominant cavitation state and activity level in a region of interest. Similar to PCDs, the cavitation imaging described here is based on the spectral analysis of the acoustic signal radiated by the cavitating microbubbles: ultraharmonics of the excitation frequency indicate stable cavitation, whereas elevated noise bands indicate inertial cavitation; the absence of both indicates moderate oscillations. The prototype system is a modified commercially available ultrasound scanner with a sector imaging probe. The lateral resolution of the system is 1.5 mm at a focal depth of 3 cm, and the axial resolution is 3 cm for a therapy pulse length of 20 mu s. The maximum frame rate of the prototype is 2 Hz. The system has been used for assessing and mapping the relative importance of the different cavitation states of a microbubble contrast agent. In vitro (tissue-mimicking flow phantom) and in vivo (heart, liver, and brain of two swine) results for cavitation states and their changes as a function of acoustic amplitude are presented

Effects Of Attenuation And Thrombus Age On The Success Of Ultrasound And Microbubble-Mediated Thrombus Dissolution

The purpose of this study was to examine the effects of applied mechanical index, incident angle, attenuation and thrombus age on the ability of 2-D vs. 3-D diagnostic ultrasound and microbubbles to dissolve thrombi. A total of 180 occlusive porcine arterial thrombi of varying age (3 or 6 h) were examined in a flow system. A tissue-mimicking phantom of varying thickness (5 to 10 cm) was placed over the thrombosed vessel and the 2-D or 3-D diagnostic transducer aligned with the thrombosed vessel using a positioning system. Diluted lipid-encapsulated microbubbles were infused during ultrasound application. Percent thrombus dissolution (%TD) was calculated by comparison of clot mass before and after treatment. Both 2-D and 3-D-guided ultrasound increased %TD compared with microbubbles alone, but %TD achieved with 6-h-old thrombi was significantly less than 3-h-old thrombi. Thrombus dissolution was achieved at 10 cm tissue-mimicking depths, even without inertial cavitation. In conclusion, diagnostic 2-D or 3-D ultrasound can dissolve thrombi with intravenous nontargeted microbubbles, even at tissue attenuation distances of up to 10 cm. This treatment modality is less effective, however, for older aged thrombi. (E-mail: [email protected]) (C) 2011 World Federation for Ultrasound in Medicine & Biology