Kile, Jarrod W, RPhD, BCPS

Reiss, Hailey

Young, Eric, MD

English

Lehigh Valley Health Network: LVHN Scholarly Works

Lehigh Valley Health Network LVHN Scholarly Works Research Scholars Poster Presentation The Impact of Multiplex Respiratory Pathogen PCR Testing at A Large Academic Institution Hailey Reiss Jarrod W. Kile RPhD, BCPS Eric Young MD Follow this and additional works at: https://scholarlyworks.lvhn.org/research-scholars-posters  Part of the Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons, and the Infectious Disease Commons This Poster is brought to you for free and open access by LVHN Scholarly Works. It has been accepted for inclusion in LVHN Scholarly Works by an authorized administrator. For more information, please contact LibraryServices@lvhn.org. Lehigh Valley Health Network, Allentown, Pennsylvania• Individuals with respiratory infections are often prescribed needless antibiotics and spend unnecessary time in the hospital1• Diagnosis of a specific respiratory pathogen with polymerase chain reaction (PCR) testing can reduce costs and total length of stay (LOS) for patients with positive results2,3• The goal of this study is to determine whether the results of PCR testing for respiratory pathogens impact antibiotic days of therapy (DOT), LOS, and cost at Lehigh Valley Health Network (LVHN)**Data taken from Muhlenberg and Cedar Crest hospitals.1. Dellit, T., Owens, R., McGowan, J., Gerding, D., Weinstein, R., Burke, J., Huskins, C., Paterson, D., Fishman, N., Carpenter, C., Brennan, P., Billeter, M., Hooton, T. (2007). Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship. Clinical Infectious Diseases, 44(2), 159-177. https://doi.org/10.1086/5103932. Rogers, B., Shankar, P., Jerris, R., Kotzbauer, D., Anderson, E., Watson, J., O’Brien, L., Uwindatwa, F., McNamara, K., Bost, J. (2015). Impact of a Rapid Respiratory Panel Test on Patient Outcomes. Archives of Pathology & Laboratory Medicine, 139, 636-641.3. Brendish, N., Malachira, A., Armstrong, L., Houghton, R., Aitken, S., Nyimbili, E., Ewings, S., Lillie, P., Clark, T. (2017). Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): a pragmatic, open-label, randomised controlled trial. The Lancet, 5, 401-411.4. (2020). NxTAG® Respiratory Pathogen Panel. Luminex.https://www.luminexcorp.com/nxtag-respiratory-pathogen-panel/ • A positive PCR test for respiratory viruses resulted in lower LOS, fewer DOT, and a reduction in fixed, variable, and total costs at LVHN• A positive PCR test does not influence time spent in ICU care• The targets most commonly identified through the comprehensive respiratory PCR testing were influenza a-matrix and rhinovirus/enterovirus • These findings suggest that prescribers may have reacted to the PCR test results in a way that led to the desired outcomes (shorter LOS, less antibiotic use, and decreased costs)• An alternative explanation is that individuals with negative test results had illnesses that required more antibiotics use, longer hospitalization, and were more expensive to care for• Limitations for this research included analyzing only a single year of data of the respiratory panel and did not evaluate which antibiotics were used• Strengths for this research included the large sample size and the ability to obtain direct and indirect costsBACKGROUND / INTRODUCTIONMETHODSRESULTS CONCLUSIONSDISCUSSIONTHE IMPACT OF MULTIPLEX RESPIRATORY PATHOGEN PCR TESTING AT A LARGE ACADEMIC INSTITUTIONHailey Reiss; Jarrod Kile, RPh; Eric Young, MDData for all patients who had the NxTAG® Respiratory Pathogen Panel (see Figure 1 for details) performed in 2019 at LVHN were obtained and the following information was reviewed.Data relating to DOT, LOS, and cost were analyzed to find differences between the two groups regarding these variables.REFERENCESTable 1. DemographicsPositive Target Negative Target P-ValueNumber of Patients 1547 3954 -Number of Patients Receiving ICU Care340 1289 -Age (years) 67.51 (0-104) 68.01 (1-106) 0.19Sex 0.02Female 863 (55.8%) 2002 (50.6%) -Male 684 (44.2%) 1952 (49.4%) -Race 0.27American Indian or Alaska Native2 (0.1%) 3 (0.07%) -Asian 17 (1%) 34 (0.9%) -Black or African American57 (4%) 223 (6%) -Multi-racial 73 (5%) 132 (3%) -Native Hawaiian or Other Pacific Islander1 (0.06%) 2 (0.05%) -Other 53 (3%) 121 (3%) -Not Recorded 16 (1%) 61 (2%) -White or Caucasian 1328 (86%) 3378 (85%) -Influenza A-Matrix 359 - -Rhinovirus or       Enterovirus 537 - -Other Virus 651 - -Figure 1. NxTAG® Respiratory Pathogen Panel Targets (US-IVD)4n = 3954n = 3954n = 3954n = 3954n = 3954n = 1547n = 1547n = 1547n = 1547n = 1547n = 1289n = 340

The Impact of Multiplex Respiratory Pathogen PCR Testing at A Large Academic Institution

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The Impact of Multiplex Respiratory Pathogen PCR Testing at A Large Academic Institution

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