A herbal fairness cream was formulated using herbal extracts which have potential antioxidant activity. Creams were basically formulated using the hydro alcoholic extracts of Glycyrrhiza glabra (root and Stolons),Camellia sinensis (leaf), Pleurotus osttreatus (mushroom plant). The prepared formulation were subjected to different evaluation like spreadability, pH, appearance, viscosity, drug content, irritability and antioxidant properties. The prepared formulation was found stable and effective. Among the several combination Liquorice &amp; Green Tea based preparation shows better results. From the results it was concluded that it is possible to develop creams containing herbal extracts having potent antioxidant and fairness property and can be used as the provision of a barrier to protect skin. &nbsp;&nbsp

Dubey, Aditi

Prasad, Pushpa

Roy, Amit

Journal of Applied Pharmaceutical Research

English

A herbal fairness cream was formulated using herbal extracts which have potential antioxidant activity. Creams were basically formulated using the hydro alcoholic extracts of Glycyrrhiza glabra (root and Stolons),Camellia sinensis (leaf), Pleurotus osttreatus (mushroom plant). The prepared formulation were subjected to different evaluation like spreadability, pH, appearance, viscosity, drug content, irritability and antioxidant properties. The prepared formulation was found stable and effective. Among the several combination Liquorice & Green Tea based preparation shows better results. From the results it was concluded that it is possible to develop creams containing herbal extracts having potent antioxidant and fairness property and can be used as the provision of a barrier to protect skin

Aditi Dubey

Pushpa Prasad

Amit Roy

Directory of Open Access Journals

Preparation and evaluation of herbal cream

Journal of Applied Pharmaceutical Research (JOAPR)

Journal of Applied Pharmaceutical Research ISSN No. 2348 – 0335 www.japtronline.com    April-June 2014 Volume 2                                                               Issue 2  28  For Correspondence adaditidubey55@gmail.com PREPARATION AND EVALUATION OF HERBAL CREAM Aditi Dubey*, Amit Roy, Pushpa prasad Columbia Institute of Pharmacy, Raipur, Chhattisgarh  ABSTRACT  A herbal fairness cream was formulated using herbal extracts which have potential antioxidant activity. Creams were basically formulated using the hydro alcoholic extracts of Glycyrrhiza glabra (root and Stolons),Camellia sinensis (leaf), Pleurotus osttreatus (mushroom plant). The prepared formulation were subjected to different evaluation like spreadability, pH, appearance, viscosity, drug content, irritability and antioxidant properties. The prepared formulation was found stable and effective. Among the several combination Liquorice & Green Tea based preparation shows better results. From the results it was concluded that it is possible to develop creams containing herbal extracts having potent antioxidant and fairness property and can be used as the provision of a barrier to protect skin.    Keyword: - Mushroom, Anti ageing, Herbal formulation  INTRODUCTION Fairness cream has emerged in the last 50 years to improve complexion and attractiveness. Melanin is one of the reasons for dark complexion. Melanin is primary determinant of “melanocytes” that are located in the epidermis. The increased production of melanin is human skin is called “melanogenesis”. Fairness cream blocks damages occurs due sun rays  and to some extent also reduce secretion of melanin, which is major cause behind dark color of skin. The basic idea of skin care cosmetic lies deep in the Rigveda, Yajurveda, Ayurveda, Unani and Homeopathic system of medicine[2].Herbal cosmetics are the products in which herbs are used in crude or extract form [1] .In this modern era, the knowledge and experience of usage of herbs are being blend with advanced cosmetic technology to develop a safe and elegant beauty product, which has wider range of people acceptability. Basically it is beauty invented by nature and perfected through technology. Herbs have the advantage of having no or least adverse effect and have a wide spectrum of consumer compliance. Indians are witnessing a paradigm shift from traditional methods of using home products. The concept of preferring the people with "fair-skin" has long been recognized socially and it has been the psychological and social impact on women to be fair. But in the recent years, men to have started giving importance on personal grooming, beginning with fair skin. The herbal cosmetic market has a share of almost Rs 200 crores out of an estimated Rs 2000 crores of total cosmetic industry in the country. The total cosmetic market is growing at the rate of 20-25% per annum. Out of this growth about 60% that of herbal cosmetic segment[1]. Hence with consideration of the above fact development of herbal cosmetic formulation in the form of a face cream is the ultimate objective of the study.  MATERIAL AND METHODS The green tea ( camellia sinensis  )were purchased from the vendors of local market of Raipur , Mushroom (pleurotus ostreatus) and liquorice (Glycerrhyza glabra) were collected from the medicinal plant garden and Institutional mushroom house of Columbia institute of Pharmacy C.G. Cetyl alcohol (Samar chem.) , stearic acid (Samar chem.), olive oil (Samar chem.), SLS(Lobachemie).  Extraction method The collected plant materials were dried in shade and grinded to form coarse particle by mechanical means. Green tea, liquorices’ and mushroom were extracted respectively using hydro alcoholic solvent (cold maceration process) at the ratio (70:30). The extracts Journal of Applied Pharmaceutical Research ISSN No. 2348 – 0335 www.japtronline.com    April-June 2014 Volume 2                                                               Issue 2  29  were dried properly and stored in a well closed container. Preparation of herbal cream  Specific quantity of cetyl alcohol, sodium lauryl sulfate and stearic acid were warmed up to 700 C. Then add few drops of olive oil and homogeneously mixed it. After that add few drops of water with continuous stirring until it gets cool and proper consistency was achieved. Mean while, weigh active ingredients and add small amount of methanol to form its paste. Combine the above cream with the paste of active constituents to form formulation. The different proportion of extract was mixed in base material to prepare herbal Fairness cream.   Evaluation of herbal cream Determination of pH The pH of the prepared formulations was evaluated by using digital pH meter. Formulations were introduced to the tip of previously calibrated pH meter and the results were noted.2  Determination of viscosity & rheology study  The viscosity of cream was determined by using Brookfield viscometer. The cream was placed in the sample holder and the suitable spindle selected was lowered perpendicularly into the sample. The spindle was attached to viscometer and then it was allowed to rotate at a constant optimum speed at room temperature. The readings were measured after few minutes.3  Spreadability- The parallel plate method is the most widely used method for determining and quantifying the spread ability of cream preparations. The spreadability can be determine by using formula S = M.L/T Where,  M = weight tied to upper slide,  L = Length of glass slide T = Time taken to separate the slide Constituents Quantity in gm (w/v) F1 F2 F3 Camellia sinensis  extract 0.1 0.2 0.3 Glycerrhyza glabra extract 0.3 0.1 0.2 Pleurotus ostreatus extract 0.2 0.3 0.1 Cetyl alcohol 5 5 5 Stearic acid 10 10 10 Olive oil 10 10 10 Sodium lauryl sulfate 5 5 5 Water 70 70 70  Homogeneity The formulations were tested for homogeneity centrifugation techniques. The formulations were subjected to centrifuge machine and processes of centrifugation was performed at a suitable speed. After the processes rate of phase separation were observed by visual appearance.4   Drug content The study was performed by taking 1gm of prepared gel and transfer into 25 ml of distilled water. The content was kept for 24 hrs at continuous agnation by rotary shaker. The percentage drug content were evaluated by means of UV analysis.6   Physical stability- The ability of cream to maintain its consistency was determined by keeping it at 250C for 30 days and at higher temperature around 700C for 15 day.   Formulation pH Spreadability (cm2) Viscosity (centipoises) %Drug content F1 64 7.2 12500 97.3 F2 6.1 6.8 10500 94.2 F3 6.6 9.6 13500 96.4 Journal of Applied Pharmaceutical Research ISSN No. 2348 – 0335 www.japtronline.com    April-June 2014 Volume 2                                                               Issue 2  30  Table 1: Table shows values for, pH, spreadability and viscosity of the various formulation.  Days Temperature Formulation Parameters    pH X1 X2 X3 X4 X5 X6 0 Room temp. F1 6.7 ** NCC ** E NG ES  Room temp. F2 6.6 ** NCC ** E NG ES  400 C+10 C F3 6.5 ** NCC ** E NG ES 5 Room temp. F1 6.6 ** NCC ** E NG ES  400 C +10 C F2 6.4 ** NCC ** E NG ES   F3 6.3 ** NCC ** E NG ES 10 Room temp. F1 6.6 ** NCC ** E NG ES  40 0C +1 0C F2 6.4 ** NCC ** E NG ES   F3 6.3 ** NCC ** E NG ES 15 Room temp. F1 6.6 ** NCC ** E NG ES   F2 6.5 ** NCC ** E NG ES  40 0C +10 C F3 6.4 ** NCC ** E NG ES 20 Room temp. F1 6.6 ** NCC ** E NG ES  400 C +10 C F2 6.4 ** NCC ** E NG ES   F3 6.3 ** NCC ** E NG ES 25 Room temp. F1 6.7 ** NCC ** E NG ES  40 0C +1 0C F2 6.4 ** NCC ** E NG ES   F3 6.3 ** NCC ** E NG ES Table no. -02. Physical parameter of F1 and F2,F3 cream on room and accelerated temperatureWhere, X1-Homogenity, X2-Appearance, X3-Spreadibility, X4-After feel, X5-Type of smear, X6-Removal, **: Good, *: Satisfactory, E: Emollient, NG: Non-greasy, ES: Easy, NCC: Not change in colour. DISCUSSION The prepared formulations were found to be stable and uniform as per the visual observation. The Ph of all the formulations were ranges in between 6-6.5, it is considered as suitable for topical application. The formulation shows good Spreadibility which was found to be within the range 6.8- 9. Viscosity of all the prepared gels was measured by means of brook fill viscometer. The result shows that concentration of polymer influence the viscosity parameter of the formulation which might have some influence on spreading property of formulation. The prepared formulations were found stable in different temperature condition hence it might be state that the prepared formulations were stable. The formulations were not shows any skin irritation. Journal of Applied Pharmaceutical Research ISSN No. 2348 – 0335 www.japtronline.com    April-June 2014 Volume 2                                                               Issue 2  31  CONCLUSION Based on the resultant data obtained from the different evaluation parameters it can be concluded that the prepared formulations were stable and safe to use. Extracts of camellia sinensis, and Glycerrhyzaglabra, Pleurotusostreatusin in different ratio may serve the purpose of imparting beautification and preventive effect on skin. Further studies are required to establish the fact and produce herbal better formulations that can be utilize for the benefit of mankind.  ACKNOWLEDGEMENT Author would like to convey sincere gratitude to research centre Columbia institute of pharmacy Raipur (CG).   REFERENCES 1. William James cunliffe,by the reprinted 1991-1993 martin dunizitd, Londan,  pg no.12. 2. Sayyed Faisal H aider Zaidi .KazukiYamda,differentactivity of medicinal plants, employed for the treatment of skin. 3. Liquorices and green tea lotus herbal cream preparationpvt. Ltd.  4. NIIR Board of technologist hand book on herbal product volume -1, Published by national institute of industrial research. 5. Herbal beauty product with formulation and process,Published by Asia pacific business press inc.,distributed by national institute of industrial research. 6. Herbal cosmetic and beauty product with formulation, printed and published by engineering India research institute,distributed by small industry research. 7. Brande E.(1799)Mr. E.Brande on a poisonous species of ogaric .The medical &Physical journals: containing the earliest information on subjects of medicine surgery pharmacy. chemisry& natural history3:41. 8. Bandyopadhay et. al, The role of antioxidant activity of Phyllanthusemblica fruits prevention from indomethacine inducedgastric ulcer, Journal of Ethnopharmacology 70(2), 2000 171-176 9.  Chin Y.W et.al, Antioxidant constituents of the roots and stolons of licorice, J. Agric Food. Chem. 13:55(12): 2007, 4691-4692. 10.  Patricia Maria et al. Moisturizing effect of cosmetic formulations containing green tea, liquoriceextract in different concentrationsassessed by skin bioengineering technique. International Journal of Dermatology, 30. (10 ) 2004, 679-683.  Received  26th April 2014 Revised 28st May 2014 Accepted  15th June 2014 J. App. Pharm. Res., 2 (2); 2014: 28 – 31   

Preparation and evaluation of herbal cream

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