The existence of various types of joints, one of the typical characteristics of prefabricated lining structures, makes the mechanical performance of shield tunnel linings quite different from that of monolithic linings. A simplified calculation method for the dynamic elastic-plastic analysis of segment lining subjected to explosive loads is proposed. The lining is composed of a number of rigid arch segments that are interconnected by elastic-plastic hinges. The dynamic interaction between the segments and the bolts, and the interaction between tunnel lining segment and soil-structure can be properly simulated with the method. As an example, the calculation of the shield section of Nanjing metro subjected to blast loading was discussed. The time-history curves of displacement and speed of some key points of section lining were obtained. Furthermore, the influences of rock grade and joint stiffness on dynamic response of tunnel lining were taken into account. The result indicates that the simplified method of blasting response analysis can reflect the response of structure subjected to blast loading accurately. The results will be a reference for antiknock analysis and design of tunnel lining