New conception of the function of the general vasodilator reflexes

Abstract

A survey of the literature regarding the vasodepressor and cardiodepressor reflexes is given. Evidence is put forward that the impulses which arise from the cardioaortic and carotid sinus regions control not only the normal vagus restraint of the heart but also the capacity of the circulation. Loss of these impulses not only causes cardiac acceleration but results in an increased return of venous blood to the heart. It is shown that conditions which are believed to be produced in exercise and which are known to reduce the vagus restraint of the heart at the same time reduce the effect of the carotid sinus impulses upon the vessels. The view is therefore put forward that an important function of the vasodepressor reflxes is to control the capacity of the circulation in order to provide a reserve of blood for use in physical exercise, just as is provided a cardiac reserve to deal with such blood maintained by similar reflex mechanisms. The possible clinical significance of the findings is indicated, and a bibliography of the literature referred to in the text is given

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