Dawson, Ellen A.

Secher, Niels H.

Volianitis, Stefanos

Warberg, Jørgen

Yoshiga, Chie

English

    Aalborg UniversitetPlasma atrial natriuretic peptide vs. CVP for evaluation of preload to the heart duringexercise in humansVolianitis, Stefanos; Yoshiga, Chie; Dawson, Ellen A.; Warberg, Jørgen; Secher, Niels H.Publication date:2018Document VersionPublisher's PDF, also known as Version of recordLink to publication from Aalborg UniversityCitation for published version (APA):Volianitis, S., Yoshiga, C., Dawson, E. A., Warberg, J., & Secher, N. H. (2018). Plasma atrial natriuretic peptidevs. CVP for evaluation of preload to the heart during exercise in humans. Poster presented at 23rd AnnualCongress of the European College of Sport Science, ECSS, Dublin, Ireland.General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            ? Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            ? You may not further distribute the material or use it for any profit-making activity or commercial gain            ? You may freely distribute the URL identifying the publication in the public portal ?Take down policyIf you believe that this document breaches copyright please contact us at vbn@aub.aau.dk providing details, and we will remove access tothe work immediately and investigate your claim.Downloaded from vbn.aau.dk on: December 27, 2020Plasma atrial natriuretic peptide vs. CVP for evaluation of preload to the heart during exercise in humans Stefanos Volianitis 1, 3, Chie Yoshiga 1, Ellen A. Dawson 1, 2, Jørgen Warberg 4, Niels H. Secher 11 Department of Anesthesia, The Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Denmark, 2 Faculty of Science, School of Sport and Exercise Sciences, Liverpool John MooresUniversity, United Kingdom, 3 Sport Sciences, Department of Health Science and Technology, Aalborg University, Denmark, 4 Department of Biomedicine, The Panum Institute, University of Copenhagen, DenmarkIntroduction: In an upright posture, central venous pressure (CVP)becomes negative, in parallel with reduction in the central bloodvolume and, consequently, preload to the heart and cardiac output(CO) decreases (Harms et al. 2003). The influence of orthostaticreduction in CVP on preload to the heart is not established. Duringexercise leg muscles pump blood from the legs towards the heart(Beecher et al. 1936) as illustrated by enhanced plasma ANP,apparently with little influence on CVP (Vogelsang et al. 2006). Wehypothesized that even though orthostasis reduces CVP also duringexercise, the increased cardiac preload brings about an increase inCO.Aim: This study evaluated the effect of the presumed different centralvenous pressure (CVP) response to running and rowing on preload tothe heart. Preload was indicated by distension of the atrium asevaluated by plasma arterial natriuretic peptide (ANP) and related tocardiac output (CO).Conclusion: During exercise the increase in CO is curvilinearlyrelated to plasma ANP, as an indication of preload to the heart, but it is unrelated to CVP. The results indicate that in the upright posture CVP reflects the gravitational influence on central venous blood and not preload to the heart.References.Harms MP et al (2003). Exp Physiol 88:611-616.Beecher HK et al. (1936). Skand Arch Physiol 73:133-141.Vogelsang TW et al. (2006). Exp Physiol 91:765-771.Schütten HJ et al (1987). Acta Physiol Scand 31:265-272.Results: While sitting CO was 6.2 ± 1.6 l/min, plasma ANP 70 ± 10pg/ml, and CVP 1.8 ± 1.1mmHg (mean ± SD) and decreased to 5.9 ±1.0 l/min, 63 ± 10 pg/ml, and -3.8 ± 1.2 mmHg when standing (P <0.05). Ergometer rowing elicited an increase in CO to 22.5 ± 5.5 l/minas plasma ANP increased to 156 ± 11 pg/ml and CVP to 3.8 ± 0.9mmHg (P < 0.05). Similarly, CO increased to 23.5 ± 6.0 l/min duringrunning with albeit smaller (P < 0.05) increase in plasma ANP, but withlittle change in CVP (around -0.9 ± 0.4 mmHg)Methods: Seven healthy subjects (four men; 26 ± 3 years; 181± 8 cmheight; and 76 ± 11 kg, weight; mean ± SD) performed, in randomorder, rowing on an ergometer (Concept II, Morrisville, VT, USA) andwalking followed by running on a treadmill (Runrace, Technogym,Gambettola, Italy) at three intensities aiming at heart rate (HR) of 120,140, and 160 beats per minute and lasting about 7 min each.Cardiovascular variablesCVP was measured from a catheter advanced to the right atrium andmean arterial pressure (MAP) was determined from the radial artery.A modified Modelflow method estimated CO from the radial arterialpressure (Finapres Medical Systems, Amsterdam, the Netherlands).HR was recorded from a three-lead electrocardiogram (Medicotest Q-10-A, Copenhagen, Denmark).Blood samples from the radial artery and the central venous catheterwere analyzed for pH, oxygen saturation (SO2) and tension (PO2)(ABL, Radiometer, Copenhagen, Denmark). Also, arterial samples (inEDTA tubes) were analyzed for ANP by radioimmunoassay (Schüttenet al. 1987).Figures. Logarithmic and linear regressions between cardiac output (CO), plasma atrial natriuretic peptide (ANP, left) and central venous pressure (CVP, above) at rest and during three exercise intensities for running and rowing (n = 7, P < 0.05). 

Plasma atrial natriuretic peptide vs. CVP for evaluation of preload to the heart during exercise in humans

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Plasma atrial natriuretic peptide vs. CVP for evaluation of preload to the heart during exercise in humans

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