With the rapid development of the highway network construction and heavy-duty vehicle market, the rollover accidents of heavy-duty vehicle continue to increase. In order to improve rollover stability of vehicle, a four degree of freedom (DOF) heavy-duty vehicle model is established. An anti-rollover control strategy is designed by using differential braking system to control the lateral load transfer rate (LTR). The dynamic simulation of vehicle with and without control is fulfilled in Matlab/Simulink. Then, the vehicle responses under typical angle step input are compared and analyzed with different road surface adhesion coefficient, vehicle speed, steering wheel angle and vehicle load. The results show that the proposed control strategy is able to improve vehicle rollover stability greatly and is also beneficial to vehicle yaw stability. The increase of road surface adhesion coefficient, vehicle speed, steering wheel angle or vehicle load has positive correlation with the rollover control effect