1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists.

Authors
Publication date
1 January 2006
Publisher
'Elsevier BV'

Abstract

A series of highly potent and selective PPARdelta agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes up to 10 microM, making it a useful tool in studying the biological effects of selective PPARdelta activation

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