According to the latest World Health Organization report (2012), suicide was the second leading cause of death among people. Approximately 90% of suicide victims or suicide attempters are diagnosed with a psychiatric disorder. Schizophrenia patients have been shown to be at an increased risk for suicide. Although many risk factors have been identified, few of these factors have a significant clinical impact on predicting suicide. Whether genetic and epigenetic alterations are potential risk factors for suicidal behavior in schizophrenia has yet to be investigated. A well-characterized sample of schizophrenia patients with a distinct suicide attempt history was recruited to evaluate the influence of genetic and epigenetic alterations as potential risk factors for suicidal behavior. Sociocultural and clinical variables were also examined. Selected genes were genotyped to test whether independently or combined, specific clinical variables and DNA variants can accurately predict suicidal behavior. Our study found no evidence that genetic or epigenetic factors have a significant influence on the risk for suicidal behavior in schizophrenia.Ph.D
