362-367A series of thiol
derivatives containing imidazole moiety have been synthesized by cyclisation of
ethyl acetoacetate with substituted aromatic amines in presence of potassium thiocynate
to form tetra substituted compounds which are oxidized in presence of selenium dioxide
to afford diketo compound 2-(4-ethoxy-1-(4-hydroxyphenyl)-2-mercapto-1H-imidazol-5-yl)-2-oxoacetaldehyde
2. The compound <b style="mso-bidi-font-weight:
normal">2 on condensation with different aromatic aldehydes forms thiol derivatives
3a-j. The structural elucidation of all
the synthesized compounds have been confirmed by their spectral/elemental data analysis.
All the synthesized thiol derivatives have been investigated for their antibacterial
and antifungal activity and show moderate to very good activity