Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
Abstract
Psoriasis is a chronic inflammatory skin disorder that may drastically
impair the quality of life of a patient. Among the various modes of
treatments for psoriasis, topical therapy is most commonly used in
majority of patients. The topical formulations based on conventional
excipients could serve the purpose only to a limited extent. With the
advent of newer biocompatible and biodegradable materials like
phospholipids, and cutting-edge drug delivery technologies like
liposomes, solid lipid nanoparticles (SLNs), microemulsions, and
nanoemulsions, the possibility to improve the efficacy and safety of
the topical products has increased manifold. Improved understanding of
the dermal delivery aspects and that of designing and developing
diverse carrier systems have brought in further novelty in this
approach. Substantial efforts and the consequent publications, patents
and product development studies on the subject are the matter of
interest and review of this article. However, majority of the work is
related to the preclinical studies and demands further clinical
assessment in psoriasis patients