Foley, Éimear M

Kappelmann, Nils

Khandaker, Golam

Parkinson, Joel

BackgroundWhether depressed patients with evidence of inflammation are more appropriate candidates for immunotherapies is being tested in clinical trials. However, studies of the clinical and phenotypic profile of depressed patients with evidence of inflammation are relatively scarce. MethodsWe investigated clinical characteristics of 84 patients meeting International Classification of Diseases 10th Revision criteria for current depressive episode, grouped as those with and without evidence of inflammation. ResultsAfter adjusting for potential confounders, regression analyses showed that inflammation (C-reactive protein ≥ 3mg/L) was associated with higher depression severity (adjusted mean difference=8.82; 95% CI, 3.91-13.72), somatic symptoms (adjusted mean difference=3.25; 95% CI, 1.58-4.92), state anxiety (adjusted mean difference=9.25; 95% CI, 3.82-14.67), perceived stress (adjusted mean difference=4.58; 95% CI, 1.98-7.18), and fatigue (adjusted mean difference=9.71; 95% CI, 3.09-6.33), but not anhedonia. This group also had poorer quality of life (adjusted mean difference=-0.18; 95% CI, -0.32-0.05). At individual depressive symptom level, the inflammation group had increased guilty feelings (adjusted OR=7.28; 95% CI, 2.09-31.17), pessimism (adjusted OR=5.38; 95% CI, 1.53-22.73), concentration difficulties (adjusted OR=4.56; 95% CI, 1.32-19.02), and indecisiveness (adjusted OR=4.21; 95% CI, 1.15-18.54). ConclusionsWe highlight clinical features associated with inflammation-related depression. These results could aid patient selection in future clinical trials testing immunotherapies in depression. Replication of these findings in larger samples is required

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Clinical phenotypes of depressed patients with evidence of inflammation

http://hdl.handle.net/1983/d1651a24-dc66-4bd6-b23d-0d7bd8855409

Clinical phenotypes of depressed patients with evidence of inflammation

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