A study of the luminescence properties of alpha-1-acid glycoprotein
(α1AAGP) and its basic drug binding properties was carried out.
The fluorescence and phosphorescence properties of the protein were
studied. The luminescence were found not to differ from those of a typical
protein.
The effect of basic drug binding on the α1AAGP fluorescence or
the drug fluorescence quantum yield was investigated. Drugs studied were;
propranolol, chlorpromazine and imipramine. Only chlorpromazine showed
quenching of the protein fluorescence. [Continues.
