Abdel-Wahab, Mohamed

Abramowitz, Yigal

Arai, Takahide

Barbanti, Marco

Bedgoni, Francesco

Blanke, Philipp

Bleiziffer, Sabine

Butter, Christian

Chakravarty, Tarun

Chevalier, Bernard

Colombo, Antonio

De Backer, Ole

Delgado, Victoria

Deuschl, Florian

Dvir, Danny

Ensminger, Stephan M

Fujita, Buntaro

Hildick-Smith, David

Holy, Erik W

J Bax, Jeroen

Kaneko, Hidehiro

Kao, Hsien-Li

Kawamori, Hiroyuki

Khalique, Omar K

Kim, Hyo-Soo

Kodali, Susheel K.

Kong, William K F

Kuwata, Shingo

Latib, Azeem

Lee, Michael

Lefèvre, Thierry

Leipsic, Jonathon

Leon, Martin B

Maeno, Yoshio

Makkar, Raj R

Modine, Thomas

Nakamura, Mamoo

Neumann, Franz-Josef

Nietlispach, Fabian

Ohno, Yohei

Pache, Gregor

Park, Seung-Jung

Perlman, Gidon Y

Ruile, Philipp

Saraf, Smriti

Schaefer, Ulrich

Schmidt, Tobias

Schofer, Niklas

Sharma, Rahul

Sugiyama, Daisuke

Søndergaard, Lars

Takahashi, Masao

Tamburino, Corrado

Tay, Edgar

Teiger, Emmanuel

Testa, Luca

Webb, John G

Whisenant, Brian K

Wong, S Chiu

Yong, Gerald

Yoon, Sung-Han

Ziegelmueller, Johannes

English

Yoon, S.H.

Bleiziffer, S.

Backer, O. de

Delgado, V.

Arai, T.

Ziegelmueller, J.

Barbanti, M.

Sharma, R.

Perlman, G.Y.

Khalique, O.K.

Holy, E.W.

Saraf, S.

Deuschl, F.

Fujita, B.

Ruile, P.

Neumann, F.J.

Pache, G.

Takahashi, M.

Kaneko, H.

Schmidt, T.

Ohno, Y.

Schofer, N.

Kong, W.K.F.

Tay, E.

Sugiyama, D.

Kawamori, H.

Maeno, Y.

Abramowitz, Y.

Chakravarty, T.

Nakamura, M.

Kuwata, S.

Yong, G.

Kao, H.L.

Lee, M.

Kim, H.S.

Modine, T.

Wong, S.C.

Bedgoni, F.

Testa, L.

Teiger, E.

Butter, C.

Ensminger, S.M.

Schaefer, U.

Dvir, D.

Blanke, P.

Leipsic, J.

Nietlispach, F.

Abdel-Wahab, M.

Chevalier, B.

Tamburino, C.

Hildick-Smith, D.

Whisenant, B.K.

Park, S.J.

Colombo, A.

Latib, A.

Kodali, S.K.

Bax, J.J.

Sondergaard, L.

Webb, J.G.

Lefevre, T.

Leon, M.B.

Makkar, R.

NARCIS 

Outcomes in Transcatheter Aortic Valve Replacement for Bicuspid Versus Tricuspid Aortic Valve Stenosis

BACKGROUND: Transcatheter aortic valve replacement (TAVR) is being increasingly performed in patients with bicuspid aortic valve stenosis (AS).OBJECTIVES: This study sought to compare the procedural and clinical outcomes in patients with bicuspid versus tricuspid AS from the Bicuspid AS TAVR multicenter registry.METHODS: Outcomes of 561 patients with bicuspid AS and 4,546 patients with tricuspid AS were compared after propensity score matching, assembling 546 pairs of patients with similar baseline characteristics. Procedural and clinical outcomes were recorded according to Valve Academic Research Consortium-2 criteria.RESULTS: Compared with patients with tricuspid AS, patients with bicuspid AS had more frequent conversion to surgery (2.0% vs. 0.2%; p = 0.006) and a significantly lower device success rate (85.3% vs. 91.4%; p = 0.002). Early-generation devices were implanted in 320 patients with bicuspid and 321 patients with tricuspid AS, whereas new-generation devices were implanted in 226 and 225 patients with bicuspid and tricuspid AS, respectively. Within the group receiving early-generation devices, bicuspid AS had more frequent aortic root injury (4.5% vs. 0.0%; p = 0.015) when receiving the balloon-expanding device, and moderate-to-severe paravalvular leak (19.4% vs. 10.5%; p = 0.02) when receiving the self-expanding device. Among patients with new-generation devices, however, procedural results were comparable across different prostheses. The cumulative all-cause mortality rates at 2 years were comparable between bicuspid and tricuspid AS (17.2% vs. 19.4%; p = 0.28).CONCLUSIONS: Compared with tricuspid AS, TAVR in bicuspid AS was associated with a similar prognosis, but lower device success rate. Procedural differences were observed in patients treated with the early-generation devices, whereas no differences were observed with the new-generation devices.</p

Copenhagen University Research Information System

Outcomes in Transcatheter Aortic Valve Replacement for Bicuspid Versus Tricuspid Aortic Valve Stenosis

Leiden University Scholary Publications

https://curis.ku.dk/portal/files/197846638/1_s2.0_S0735109717360412_main.pdf

Outcomes in Transcatheter Aortic Valve Replacement for Bicuspid Versus Tricuspid Aortic Valve Stenosis

Abstract

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NARCIS

Copenhagen University Research Information System

Leiden University Scholary Publications