Efficacy and Safety of Once-daily Oxybutynin Patch in Patients with Overactive Bladder Who had Experienced Adverse Reactions Caused by Oral Antimuscarinic Drugs
Objectives：To evaluate the efficacy and safety of once-daily oxybutynin patch for overactive bladder (OAB) patients not tolerating oral antimuscarinic drugs. Methods：We prospectively investigated 43 OAB patients treated with once-daily oxybutynin patches for dry mouth and constipation due to oral antimuscarinic drugs. Results：Oxybutynin patch treatment for 8 weeks significantly improved the visual analogue scale scores for dry mouth and constipation；total score and subscore (mean number of urgency episodes and daily micturitions) for OAB symptoms；and King’s Health Questionnaire scores for social limitations, emotions and sleep/energy (P＝0.016 and 0.001；0.008, 0.041 and 0.015；and 0.007, 0.003 and 0.026, respectively). The 3-day frequency volume chart showed significant improvement in hours of undisturbed sleep（P＝0.011）. Eight patients had adverse reactions at the application site and withdrew from the study, while others only developed mild erythema and pruritus. Conclusions：Oxybutynin patch reduces adverse reactions caused by oral antimuscarinic drugs
