The effects of season and enterprise on cow milk production indicators between 2008 and 2012 in the province of Ciego de Ávila, Cuba, are presented. Official information of the productive, economic, and financial indicators from the Economic and Production Departments of the enterprises evaluated was used. The mean productivity and effi-ciency indicators were calculated from the basic information collected. Descriptive statistical analysis and variable comparisons between seasons and enterprises were made. The bio-economic indicators in the rainy season produced the least unfavorable results. More than one milk kg/cow was produced in the rainy season, and yields per area had a mean of 8.2 and 12.9 kg of milk/ha/month in the dry and rainy seasons, respectively. Different results were observed in annual efficiency and production indicators, both primary and secondary. Ruta Invasora was the enterprise with the best productive results; whereas Orlando González Enterprise had the highest overall yields