CAVALIER, Etienne

Claisse, Guillaume

DAMAS, Pierre

DELANAYE, Pierre

DUBOIS, Bernard

KRZESINSKI, Jean-Marie

LAMBERMONT, Bernard

Lautrette, Alexandre

Maillard, Nicolas

Mariat, Christophe

Mehdi, Manoli

Morel, Jérôme

BMC Nephrology

PubMed

Pierre Delanaye

Etienne Cavalier

Jérôme Morel

Manolie Mehdi

Nicolas Maillard

Guillaume Claisse

Bernard Lambermont

Bernard E Dubois

Pierre Damas

Jean-Marie Krzesinski

Alexandre Lautrette

Christophe Mariat

Crossref

Detection of decreased glomerular filtration rate in intensive care units: serum cystatin C versusserum creatinine

International audienceBACKGROUND: Detecting impaired glomerular filtration rate (GFR) is important in intensive care units (ICU) in order to diagnose acute kidney injuries and adjust the dose of renally excreted drugs. Whether serum Cystatin C (SCysC) may better reflect glomerular filtration rate than serum creatinine (SCr) in the context of intensive care medicine is uncertain. METHODS: We compared the performance of SCysC and SCr as biomarkers of GFR in 47 critically ill patients (median SOFA (Sepsis-related Organ Failure Assessment) score of 5) for whom GFR was measured by a reference method (urinary clearance of iohexol). RESULTS: Mean Iohexol clearance averaged 96 ± 54 mL/min and was under 60 mL/min in 28% of patients. Mean SCr and SCysC concentrations were 0.70 ± 0.33 mg/dL and 1.26 ± 0.61 mg/L, respectively. Area under the ROC curve for a GFR threshold of 60 mL/min was 0.799 and 0.942 for SCr and SCysC, respectively (p = 0.014). CONCLUSIONS: We conclude that ScysC significantly outperfoms SCr for the detection of an impaired GFR in critically ill patients. TRIAL REGISTRATION: ClinicalTrials.gov: B7072006347

Delanaye, Pierre

Cavalier, Etienne

Mehdi, Manolie

Lambermont, Bernard

Dubois, Bernard E

Damas, Pierre

Krzesinski, Jean-Marie

HAL: Hyper Article en Ligne

Detection of decreased glomerular filtration rate in intensive care units: serum cystatin C versus serum creatinine.

Springer - Publisher Connector

Morel, Jérome

Dubois, Bernard

HAL Clermont Université

A: Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults.

al: Estimating glomerular filtration rate from serum creatinine and cystatin C.

AS: Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem

Bjursten H: Evaluation of cystatin C with iohexol clearance in cardiac surgery. Acta Anaesthesiol Scand

Boudaoud S: Evaluation of renal function in intensive care: plasma cystatin C vs. creatinine and derived glomerular filtration rate estimates. Clin Chem Lab Med

Colardyn FA: Assessment of renal function in recently admitted critically ill patients with normal serum creatinine. Nephrol Dial Transplant

Cystatin C in acute kidney injury. Curr Opin Crit Care

Cystatin C in prediction of acute kidney injury: a systemic review and meta-analysis.

de Jong PE: Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. Kidney Int

Delanaye P: Performance of iohexol determination in serum and urine by HPLC: validation, risk and uncertainty assessment. Clin Chim Acta

Endre ZH: Rapid detection of acute kidney injury by plasma cystatin C in the intensive care unit. Nephrol Dial Transplant 2010, 25:3283–3289. Delanaye et al.

JM: Cystatin C or creatinine for detection of stage 3 chronic kidney disease in anorexia nervosa. Nephron Clin Pract

Kribben A: Early detection of acute renal failure by serum cystatin C. Kidney Int

Lente F: Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med

Luo XH: Assessment of glomerular filtration rate by serum cystatin C in patients undergoing coronary artery bypass grafting. Ann Clin Biochem

Morelon E, et al: GFR estimation using standardized cystatin C in kidney transplant recipients.

Pergola PE: Prediction of GFR in liver transplant candidates.

PM: Performance of the cockcroft-gault and modification of diet in renal disease equations in estimating GFR in ill hospitalized patients.

Retooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely.

Rorive G: Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units. Intensive Care Med

Sobrado A: Assessing glomerular filtration rate in hospitalized patients: a comparison between CKD-EPI and four cystatin C-based equations.

Detection of decreased glomerular filtration rate in intensive care units: serum cystatin C versus serum creatinine

Detection of decreased glomerular filtration rate in intensive care units: serum cystatin C versus serum creatinine

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HAL: Hyper Article en Ligne

Springer - Publisher Connector

Springer - Publisher Connector

HAL Clermont Université