Genetic and chemical-molecular approach to study persistence in Pseudomonas aeruginosa to combat chronic infections

Abstract

<w:latentstyles  Here, we aim to obtain more insight into the mechanistic basis of persistence of P. aeruginosa by characterizing a newly identified gene with a role in antibiotic tolerance. Secondly, we initiated a new research line in which a top-down approach was used to identify compounds that, in combination with conventional antibiotics, reduce the persister fraction of P. aeruginosa.status: publishe