__Abstract__
__Background__ The effect of lead time in time trade-off
(TTO) valuation is not well understood. The purpose of this
study was to investigate the effects on health-state valuation
of the length of lead time and the way the lead-time
TTO task is displayed visually.
__Methods__ Using two general population samples, we
compared three lead-time TTO variants: 10 years of lead
time in full health preceding 5 years of unhealthy time
(standard); 5 years of lead time preceding 5 years of
unhealthy time (experimental); and 10 years of lead time
and 5 years of unhealthy time, presented with a visual aid
to highlight the point where the lead time ends (experimental).
Participants were randomized to receive one of the
lead-time variants, as administered by a computer software
program.
__Results__ Health-state values generated by TTO valuation
tasks using a longer lead time were slightly lower than
those generated by tasks using a shorter lead time. When
lead time and unhealthy time were presented with visual
aids highlighting the difference between the lead time and
unhealthy time, respondents spent more time considering
health states with a value close to 0.
__Conclusions__ Different lead-time time trade-off variants
should be carefully studied in order to achieve the best
measurement of health-state values using this new method