thesis
High-Risk Percutaneous Intervention in the Drug-Eluting Stent Era
- Publication date
- 14 June 2006
- Publisher
- High-risk Intervention in the Drug-eluting stent era
The use of drug-eluting stents in high-risk interventions,
including those undertaken to treat the left main
coronary artery (Chapter 2), multivessel disease (Chapter
14) or on-going ST-segment elevation myocardial
infarction (Chapters 11 and 12) appeared overall
beneficial in comparison with traditional metallic stents.
In particular, the use of drug eluting stents was
associated to a remarkable decrease in late loss (Chapter
3) which ultimately resulted in lower need for re-
intervention (Chapter 2), while no clear effect on death
and myocardial infarction was observed.
The safety profile of these new coronary devices
appeared overall consistent with what has been reported
in the pivotal trials focusing on selected patient/lesion
subsets (Chapters 2, 3, 7, 8, 12, 14, 15, 16). The
incidence of possible or confirmed acute, sub-acute or
late thrombosis was low in this high-risk subset of
patients patients undergoing treatment for left main
coronary artery disease (Chapters 2, 3, 7, 8, 12, 14, 15,
16) and importantly we could not confirm previous
concerns regarding the potential association between
intimal hyperplasia and sudden death in patients
undergoing treatment for left main coronary artery
disease (Chapters 7 and 8).