Brandenberger

Catherine J. Murphy

Choi

Elissa M. Grzincic

Favi

Grzincic

Khan

Patra

Poma

Priscila Falagan-Lotsch

Schaeublin

Soenen

Vance

Yang

Zhang

Zhou

Significance
          Gold nanoparticles are promising candidates for optical sensing, bioimaging, delivery, and therapeutic applications due to their size- and shape-dependent physical properties and inherent biocompatibility compared with other metallic nanoparticles. Many studies have found that these particles are generally nontoxic at low doses for most, but not all, initial surface treatments. In this study, a long-term (20 wk) exposure of a set of gold nanoparticles to a human cell line was performed in two ways: an acute burst of nanoparticle exposure compared with a continuous, chronic exposure at the same concentration. Overall, it was found that an acute burst of exposure is more harmful to cells, and that cells can adapt to long-term nanoparticle exposure.</jats:p

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Proceedings of the National Academy of Sciences

One low-dose exposure of gold nanoparticles induces long-term changes in human cells

One low-dose exposure of gold nanoparticles induces long-term changes in human cells

Abstract

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