Drug Therapy for Managing Primary Orthostatic Hypotension

Abstract

Primary orthostatic hypotension is a condition that is overlooked and undertreated. It is clinically defined as a decrease of 20 mm Hg in systolic or 10 mm Hg in diastolic BP within 3 minutes of standing. Primary orthostatic hypotension (OH) symptoms are a result of cerebral hypoperfusion due to autonomic nervous system dysfunction leading to an overcompensation of CV mechanisms in response to reduced venous return