Cardiovascular disease is a significant cause of morbidity and mortality in patients with diabetes mellitus. The impact of tight glycemic control in the mortality has been investigated in large randomized clinical trials. The data are controversial, as some trials (ACCORD, ADVANCE and VADT) have found that intensive glycemic control either has no impact on cardiovascular outcomes or even worsens them. On the other hand, results of the 10-year follow-up of the UKPDS study suggest that tight glycemic control of younger, newly diagnosed patients with type 2 diabetes may have long term beneficial cardiovascular effects. All these data have led to the adoption of clinical guidelines suggesting a different strategy according to the patient’s age and duration of diabetes
